The importance of the coating material type and amount in the preparation of liquisolid systems based on magnesium aluminometasilicate carrier

Vraníková, Barbora; Svačinová, Petra; Marushka, Julia; Brokešová, Jana; Holas, Ondřej; Tebbens, Jurjen Duintjer; Šklubalová, Zdeňka

doi:10.1016/j.ejps.2021.105952

Cited by 8 publications

(3 citation statements)

References 51 publications

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“…Several studies reported high values for the flowable liquid-loading potential of Neusilin ® US2 [ 63 , 64 ]. A recent study [ 26 ] showed that LS admixtures of the same composition (Neusilin ® US2, PEG 400, and Aerosil ® 200) with an L f value of 0.55 and R values in the same range (10–20–30) had acceptable flowability with CI values from 14.63 to 17.71. In comparison to these results, the admixtures prepared in this research displayed good flowability with a CI mean value of 14.73 despite notably higher L f values (0.7–1.3).…”

Section: Resultsmentioning

confidence: 99%

“…The mechanical characteristics of LS tablets, such as friability and resistance to crushing, have been investigated in several studies over the years [ 5 , 20 , 21 , 22 , 23 ]. However, few recent studies have discussed the influence of formulation factors on the behavior of LSS during compaction [ 24 , 25 , 26 , 27 ] and a more detailed insight into the complex relationship between the formulation of LSS and the process parameters during all stages of compaction is still lacking. Therefore, the application of this technology requires not only a good understanding of the LS formulation and an accurate calculation of the required amounts of excipients but also an understanding of the tableting process and all its stages.…”

Section: Introductionmentioning

confidence: 99%

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Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers

et al. 2023

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The processing of liquisolid systems (LSS), which are considered a promising approach to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the relatively high amount of liquid phase incorporated within them. The objective of this study was to apply machine-learning tools to better understand the effects of formulation factors and/or tableting process parameters on the flowability and compaction properties of LSS with silica-based mesoporous excipients as carriers. In addition, the results of the flowability testing and dynamic compaction analysis of liquisolid admixtures were used to build data sets and develop predictive multivariate models. In the regression analysis, six different algorithms were used to model the relationship between tensile strength (TS), the target variable, and eight other input variables. The AdaBoost algorithm provided the best-fit model for predicting TS (coefficient of determination = 0.94), with ejection stress (ES), compaction pressure, and carrier type being the parameters that influenced its performance the most. The same algorithm was best for classification (precision = 0.90), depending on the type of carrier used, with detachment stress, ES, and TS as variables affecting the performance of the model. Furthermore, the formulations with Neusilin® US2 were able to maintain good flowability and satisfactory values of TS despite having a higher liquid load compared to the other two carriers.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers

et al. 2023

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“…Studies addressing the lack of knowledge regarding compaction behavior of liquisolid systems are still scarce. Apart from several studies reported in the last years that involve the analysis of mechanical properties (resistance to crushing, friability) of liquisolid tablets (18,(27)(28)(29)(30)(31)(32), there are only a few recent studies dealing more thoroughly with factors influencing compaction behavior of liquisolid systems (14,19), including recent papers of our research group (8,9). These studies revealed that the influence of different formulation and process parameters can significantly affect compaction behavior of LS systems and that the use of dynamic compaction analysis and mathematical models for the evaluation of compression properties could contribute to a better understanding and facilitate the optimization of the formulation and production process of LS tablets.…”

Section: Advantages and Limitations Of Liquisolid Technologymentioning

confidence: 99%

Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives

Aleksić¹,

Glišić²,

Parojčić³

2022

Arhiv za farmaciju

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Liquisolid systems are a novel, promising platform for the production of solid dosage forms with a high liquid content, i.e. dispersion of the drug in a suitable, hydrophilic, non-volatile liquid vehicle or liquid drug. This technology requires conventional, but highly porous excipients (carrier and coating material in the appropriate ratio) able to absorb/adsorb liquid medication, resulting in both good flowability and acceptable compression properties. This approach has shown great potential to improve the dissolution rate and bioavailability of poorly soluble drugs, and has been recognized as a good alternative to common, more complex and expensive techniques. A variety of applications of this simple technique have been investigated recently, including the preparation of: modified release tablets, orally disintegrating tablets, solid dosage forms with liquid herbal extracts, etc. This emerging technology has numerous advantages, and the most important are: simplicity, cost-effectiveness, applicability in large scale production and environmental friendliness. However, it is accompanied by certain challenges as well, such as limited applicability in the case of highly dosed drugs. This article aims to give a comprehensive overview of recent progress regarding the potential applications of this technology, as well as to give an insight into the new liquisolid-based techniques intending to further support its commercial applicability.

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Surface modification techniques of magnesium-based alloys for implant applications

Mahto

Singh²,

Malik³

2022

J Coat Technol Res

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The importance of the coating material type and amount in the preparation of liquisolid systems based on magnesium aluminometasilicate carrier

Cited by 8 publications

References 51 publications

Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers

Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers

Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives

Surface modification techniques of magnesium-based alloys for implant applications

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