The importance of the peripheral thyroid hormone deiodination in adaptation to ambient temperature in the chicken (Gallus domesticus)

Rudas, P.; Pethes, G.

doi:10.1016/0300-9629(84)90230-5

Cited by 54 publications

(16 citation statements)

References 19 publications

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“…Thyroid gland contains and releases primarily T 4 (McNichols and McNabb, 1987;McNabb, 2000) and circulatory concentration of T 3 is mainly produced by deiodination of T 4 in the peripheral tissues, mostly in liver and kidneys (Zhan et al, 2007). CTs increase thyroid secretion rate (TSR) (McNabb, 2000) and also T 4 conversion to T 3 (Rudas and Pethes, 1984). Therefore, significant increase in T 3 without any decline of T 4 which was observed in this study might be due to simultaneous increase in both TSR and T 4 conversion to T 3 , which resulted in significant increase of T 3 without any decline in T 4 concentrations.…”

Section: Thyroid Hormonesmentioning

confidence: 99%

Effect of early feed restriction on physiological responses, performance and ascites incidence in broiler chickens raised in normal or cold environment

Mohammadalipour

Rahmani

Jahanian

et al. 2017

Animal

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Intensive selection of broilers for faster growth and better feed efficiency resulted in greater susceptibility to metabolic disorders such as ascites syndrome, which is one of the major causes of mortality and economic loss in broiler industry. Whereas cool temperature is one of the primary triggers for ascites, early feed restriction (FDR) significantly alleviates its incidence and mortality. However, little is known about effects of FDR, cold environmental temperature and their interaction on physiological responses in broiler chickens. For this purpose, 320 one-day-old male broilers were divided into two treatment groups of Ad libitum (Ad) and feed restricted (FR) with eight pen replicates each. Chickens in FR group underwent feed access limitation from days 7 to 14 of age. On day 21 half of the birds (four pens) in each group exposed to the cold temperature (CT) and the other half (four pens) continued at normal temperature (NT). Average daily feed intake, average daily weight gain and feed conversion ratio (FCR) were measured at days 7, 14, 21, 28 and 42. At 39 and 46 days of age two chicks with a BW around the pen average were selected from each pen and slaughtered after collecting blood samples. Then, relative weight of internal organs and right ventricle weight per total ventricle weight (RV : TV) ratio were calculated. Compared with NT group, CT birds had higher daily feed intake and FCR (P < 0.05) from day 28 to 42. Cumulative ascites mortality in CT chickens was higher (P < 0.001) than NT chicks. Within the CT group, ascites mortality in FR chickens was reduced (P < 0.001) to 1.25% compared with 8.75% in Ad chicks. Birds in CT group had significantly (P < 0.05) thicker right ventricle and greater relative weight of heart, hematocrit and triiodothyronine concentration. However, none of these parameters were affected by FDR. Under cold stress conditions, FDR reduced activity of alanine aminotransferase and aspartate aminotransferase (P < 0.05). Serum triglyceride, cholesterol, high-density lipoprotein and total protein were not influenced by either temperature or feeding regimen. In conclusion, these findings suggest that FDR reduces ascites incidence mainly by allowing better development of internal organs, which helps them to cope with the high metabolic pressure and suffer less damage.

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Section: Thyroid Hormonesmentioning

confidence: 99%

Effect of early feed restriction on physiological responses, performance and ascites incidence in broiler chickens raised in normal or cold environment

Mohammadalipour

Rahmani

Jahanian

et al. 2017

Animal

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“…Depending on the developmental stage, corticosterone inhibits negative feedback on T 4 synthesis (Geris et al, 1999) and affects deiodinase enzyme activity (Decuypere et al, 1983;Darras et al, 1996). Environmental cold increases extrathyroidal conversion of T 4 to T 3 and increases thyroid hormone turnover (Rudas and Pethes, 1984). We did not, however, find any association between thyroid hormone concentrations and the influence of nestling body mass, daily temperature, or the interactive effects of corticosterone (Mayne, 2002).…”

Section: Discussionmentioning

confidence: 74%

Thyroid Function in Nestling Tree Swallows and Eastern Bluebirds Exposed to Non-Persistent Pesticides and p, p?-DDE in Apple Orchards of Southern Ontario, Canada

Mayne

Bishop²,

Martin³

et al. 2005

Ecotoxicology

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This study examined the associated effects of pesticides and persistent residues of p,p'-DDE on thyroid function in 16-day-old tree swallows (Tachycineta bicolor) and 12-day-old eastern bluebirds (Sialia sialis). Apple orchards sprayed with pesticides in current use and reference sites were chosen for study in southern Ontario, Canada, during 2000-2001. We assessed thyroid hormone concentrations (plasma and muscle thyroxine [T4], and triiodothyronine [T3]) and the response to a challenge with thyroid stimulating hormone (TSH) as well as parameters of thyroid histology. Individual nests were exposed to as many as seven individual pesticide applications and up to five pesticide mixtures. Concentrations of p,p'-DDE in eggs from both species were highest in orchard sites, and ranged from 0.05 to 5.44 mg/kg wet weight for tree swallows, and from 0.17 to 95.4 mg/kg for eastern bluebirds. In 2000, tree swallows from sprayed orchards had elevated plasma T4 concentrations, and thyroid glands with collapsed follicles, hypertrophic epithelia, and higher follicular epithelial cells relative to chicks from reference sites. Plasma T4 concentration was positively correlated with the total number of pesticide mixtures applied during egg incubation through chick rearing. In 2001, basal plasma T3 concentration in tree swallow chicks did not differ between orchard and reference sites, though there were differences among orchards; T3 was positively correlated with total number of individual sprays applied during egg incubation through chick rearing. Tree swallows challenged with TSH showed no significant difference in thyroid hormone concentration or follicular epithelial cell height between exposure groups; however, a significantly greater proportion of chicks from reference sites were found to have thyroids with focal or diffuse hypertrophic epithelia relative to orchard chicks. In 2001, bluebirds from sprayed orchards had significantly higher T3 concentrations in response to TSH challenge; this response was positively correlated with the total number of pesticides applied during egg incubation through chick rearing.

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“…In other hand, time interval in the end of heat challenge and day of hatch, in both treatments, was sufficient to compensate this decline. Also the halflives of T 3 and T 4 are essentially identical and are short (3-9 h) in birds [30] . Response of thyroid hormones to heat takes much time and in this study the length of exposure was not enough for stimulating thyroid hormones.…”

Section: Discussionmentioning

confidence: 94%

Yumurtadan Yeni Çıkmış Broiler Civcivlerde Döngüsel Yüksek İnkübasyon (Kuluçka) Sıcaklıklarının Vücut ve Organ Ağırlıkları, Tiroit Hormonları ve HSP70 Gen Ekspresyonu Üzerine Etkileri

Aminoroaya¹,

Sadeghi²,

Pirsaraei³

et al. 2016

Kafkas Univ Vet Fak Derg

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The objective of present study was to evaluate the effects of cyclical higher incubation temperatures in different embryonic ages on liver HSP70 gene expression, plasma T3, T4 and triglyceride (TG) levels, hatchability, body, heart and liver weights of newly hatched chicks. For this purpose, 2.700 fertile eggs (average weight, 58±1 g) were obtained from Arian broiler breeder at 34 weeks age. In a completely randomized design, eggs were assigned to three incubation temperature treatments at 60% relative humidity with 6 replicate per each. The treatment groups were: 1) control group that eggs were incubated at 37.6°C during incubation period, 2) incubation temperature was increased to 39°C for 3 h daily at embryonic ages from 12 to 14 in treatment 1 (TT1) and 3) incubation temperature was increased to 39°C for 3 h daily at embryonic ages from 15 to 17 in treatment 2 (TT2). All above-mentioned parameters were assessed at the day of hatch. The results showed that cyclical higher incubation temperatures did not affect body and liver weights, plasma T3, T4 and TG levels (P>0.05), while heart weights of chicks in TT1 and TT2 were lower (P<0.05) than control group. Furthermore, TT1 significantly increased liver HSP70 gene expression compared to the control group and TT2. It was concluded that cyclical higher incubation temperatures at embryonic ages from 12 to 14 could increase liver HSP70 gene expression with no effect on body and liver weights, plasma T3, T4 and TG levels at day-old chicks. Keywords: Incubation temperatures, Embryonic ages, Gene expression, Newly hatched chicks Yumurtadan Yeni Çıkmış Broiler Civcivlerde Döngüsel Yüksek İnkübasyon (Kuluçka) Sıcaklıklarının Vücut ve Organ Ağırlıkları, Tiroit Hormonları ve HSP70 Gen Ekspresyonu Üzerine Etkileri ÖzetBu çalışmanın amacı; farklı embriyonik yaşlardaki döngüsel yüksek inkübasyon sıcaklıklarının, yumurtadan yeni çıkmış civcivlerde karaciğer HSP70 gen ekspresyonu, plazma T3, T4 ve trigliserid (TG) düzeyleri ile çıkış gücü, vücut, kalp ve karaciğer ağırlıkları üzerine etkisini değerlendirmekti. Bu amaçla, 34 haftalık etçi Arian damızlıklardan (ortalama ağırlık, 58±1 g) 2.700 adet döllenmiş yumurta elde edildi. Tamamen rasgele bir dizaynla seçilen yumurtalar, her biri 6 tekrarlı tarzda %60 nispi nemde üç farklı kuluçka sıcaklık uygulaması için ayrıldı. Tedavi grupları şunlardı: 1) kontrol grubu, yumurtalar inkübasyon süresi içinde 37.6°C'de inkübe edildi, 2) Tedavi 1 (TT1), inkübasyon sıcaklığı 12-14 arası embriyonik yaşta günde 3 saat süreyle 39°C'ye yükseltildi ve 3) Tedavi 2 (TT2), inkübasyon sıcaklığı 15-17 arası embriyonik yaşta günde 3 saat süreyle 39°C'ye yükseltildi. Yukarıda belirtilen tüm parametreler, kuluçka çıkış günü değerlendirildi. Sonuçlar, döngüsel yüksek inkübasyon sıcaklıklarının TT1 ve TT2'deki civcivlerin vücut ve karaciğer ağırlıkları ile plazma T3, T4 ve TG düzeylerini etkilemezken (P>0.05), kalp ağırlıklarının ise kontrol grubuna göre daha düşük (P<0.05) olduğunu gösterdi. Ayrıca, TT1 karaciğer HSP70 gen ekspresyonunu kontrol grub...

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The importance of the peripheral thyroid hormone deiodination in adaptation to ambient temperature in the chicken (Gallus domesticus)

Cited by 54 publications

References 19 publications

Effect of early feed restriction on physiological responses, performance and ascites incidence in broiler chickens raised in normal or cold environment

Effect of early feed restriction on physiological responses, performance and ascites incidence in broiler chickens raised in normal or cold environment

Thyroid Function in Nestling Tree Swallows and Eastern Bluebirds Exposed to Non-Persistent Pesticides and p, p?-DDE in Apple Orchards of Southern Ontario, Canada

Yumurtadan Yeni Çıkmış Broiler Civcivlerde Döngüsel Yüksek İnkübasyon (Kuluçka) Sıcaklıklarının Vücut ve Organ Ağırlıkları, Tiroit Hormonları ve HSP70 Gen Ekspresyonu Üzerine Etkileri

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