The importance of the stomach in mediating histamine-induced hypocalcemia in the rat

Kaplan, Edwin L.; Norberg, Hans P.; Schulak, James A.; Hill, Barbara J.

doi:10.1016/0026-0495(76)90023-8

Cited by 7 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In spite of the importance of gastrectomy-induced osteoporosis, very little is known about the influence of the gastric mucosa on bone metabolism. Since the experimental studies of IVY (15) , who described bone loss in gastrectomized dogs, many studies have demonstrated that the gastric mucosa is related in some way to the incorporation of calcium into bone (19,20,23,31,32,37) . Despite the accepted role of gastric acid secretion in maintaining calcium absorption, the treatment of rats with a potent proton pump inhibitor resulting in almost complete achlorhydria had no effect on bone density, and, in addition, parenteral calcium supplementation did not prevent bone mineral loss in gastrectomized animals (32) .…”

Section: Bone Mineral Density Gastric Mucosa Atrophy and Hp Infectionmentioning

confidence: 99%

The presence of Helicobacter Pylori in postmenopausal women is not a factor to the decrease of bone mineral density

Kakehasi

Mendes

Coelho

et al. 2007

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Background -Osteoporosis affects approximately 30% of postmenopausal women. Gastrectomy, pernicious anemia, and more recently Helicobacter pylori infection, have all been implicated in the pathogenesis of osteoporosis. A reduced parietal cell mass is a common feature in these conditions. Aim -To study a possible relationship between chronic gastritis, parietal cell density of the oxyntic mucosa and bone mineral density in postmenopausal women, as chronic gastritis, Helicobacter pylori infection and osteoporosis are frequently observed in the elderly. Methods -Fifty postmenopausal women (61.7 ± 7 years) were submitted to gastroduodenal endoscopy and bone densitometry by dual energy X-ray absorptiometry. Glandular atrophy was evaluated objectively by the determination of parietal cell density. Helicobacter pylori infection was evaluated by histology, urease test and breath test with 13 C. Results -Thirty-two patients (64%) presented chronic multifocal gastritis, and 20 of them (40%) showed signs of gastric mucosa atrophy. Lumbar spine osteoporosis was found in 18 patients (36%). The parietal cell density in patients with and without osteoporosis was 948 ± 188 and 804 ± 203 cells/mm 2 , respectively. Ten osteoporotic patients (55%) and 24 non-osteoporotic patients (75%) were infected by Helicobacter pylori. Conclusion -Postmenopausal women with osteoporosis presented a well-preserved parietal cell density in comparison with their counterparts without osteoporosis. Helicobacter pylori infection was not different between the two groups. We concluded that neither atrophic chronic gastritis nor Helicobacter pylori seem to be a reliable risk factor to osteoporosis in postmenopausal women. HEADINGS -Postmenopause. Osteoporosis, postmenopausal. Gastritis. Helicobacter infections.

show abstract

Section: Bone Mineral Density Gastric Mucosa Atrophy and Hp Infectionmentioning

confidence: 99%

The presence of Helicobacter Pylori in postmenopausal women is not a factor to the decrease of bone mineral density

Kakehasi

Mendes

Coelho

et al. 2007

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

Calbindin 28 kDa in endocrine cells of known or putative calcium-regulating function

et al. 1989

View full text Add to dashboard Cite

The distribution of calbindin in some endocrine glands (thyroid, parathyroid, ultimobranchial body, pituitary and adrenals) and in the diffuse endocrine cells of the gut and pancreas has been investigated immunohistochemically using an antiserum raised against the 28 kDa calbindin from chicken duodenum. The identity of calbindin-immunoreactive cells in a number of avian and mammalian species was ascertained by comparison with hormone-reactive cells in consecutive sections or by double immunostaining of the same section with both calbindin and hormone antibodies. Calcitonin-producing C cells of the mammalian and avian thyroid, parathyroid or ultimobranchial body, PP, glucagon and insulin cells of the mammalian and avian pancreas, enteroglucagon cells of the avian intestine, secretin cells of the mammalian duodenum, histamine-producing ECL cells of the mammalian stomach, as well as noradrenaline-producing cells of the adrenal medulla and some (TSH?) cells of the adenohypophysis were among the calbindin-immunoreactive cells. Although some species variability has been observed in the intensity and distribution of the immunoreactivity, especially in the pancreas and the gut, a role for calbindin in the mechanisms of calcium-mediated endocrine cell stimulation or of intracellular and extracellular calcium homeostasis is suggested.

show abstract

Effect of histamine and stress on the gastric mucosal Ca2+ content during the development of gastric ulcers

et al. 1979

View full text Add to dashboard Cite

The influence of histamine, its triazole derivative (3-beta-aminoethyl-1,2,4-triazole) and immobilization stress on the gastric mucosal Ca2+ content during the development of gastric ulcers in guinea pigs and rats was investigated. A considerable fall in the concentration of Ca2+ in gastric tissues of guinea pigs after administration of histamine 0.25 mg/kg, down to 80% (8.0 mumol/g), its derivative (1 mg/kg) to 72% (7.2 mucol/g) and stress to 76% (7.6 mumol/g) was recorded by atomic absorption-spectrophotometric techniques, while the calcium level in the controls stood at 9.9 mumole/g. Similar changes (90-65%) were seen in the blood plasma. In rats, the Ca2+-decreasing effects of stress ran closely parallel with increasing ulceration, and depended on the duration of stress. The immobilization of rats evoked a slight rise in the Na+ content of the gastric tissues. After 4 h immobilization, the tissue concentration of Na+ was increased to 116% of control levels. Cimetidine (100 mumol kg-1 more than 50% inhibited the development of gastric ulcers and prevented the change in Ca2+ concentration ions. Thus, the data suggest that Ca2+ ions take part not only in the regulation of secretion, but also in stress tissue dystrophy.

show abstract

The importance of the stomach in mediating histamine-induced hypocalcemia in the rat

Cited by 7 publications

References 9 publications

The presence of Helicobacter Pylori in postmenopausal women is not a factor to the decrease of bone mineral density

The presence of Helicobacter Pylori in postmenopausal women is not a factor to the decrease of bone mineral density

Calbindin 28 kDa in endocrine cells of known or putative calcium-regulating function

Effect of histamine and stress on the gastric mucosal Ca2+ content during the development of gastric ulcers

Contact Info

Product

Resources

About