The importance of thyroid microsomal antibodies in the development of elevated serum TSH in middle‐aged women: associations with serum lipids

Abstract

The determination of serum TMA in middle-aged women can identify an important group of women at risk of developing an elevated serum TSH. TMA measurement is of potential use in the prevention of cardiovascular disease. An elevated serum TSH, however, in our study-group does not seem to be accompanied by an abnormal lipid profile, as reported by others.

Natural history of the transition from euthyroidism to overt autoimmune hypo- or hyperthyroidism: a prospective study

“…In the Whickham survey (1), the annual rate of progression from subclinical to overt hypothyroidism was 3% in women with elevated TSH levels (O6 mU/l), 2% in women with positive thyroid autoantibodies, and 4.3% when both elevated TSH and thyroid Abs were present. The importance of thyroid antibodies in the progression from subclinical to overt hypothyroidism was highlighted in other studies carried out in elderly subjects (2)(3)(4)(5)(6)(7)(8)15). In a prospective study (9) in 107 subjects over the age of 55 with spontaneous subclinical hypothyroidism and no history of thyroid disease, it was found that TSH is the most powerful predictor for the outcome of spontaneous subclinical hypothyroidism.…”

Mild Thyroid Deficiency in the Elderly

“…An age dependent increase in serum TSH concentrations was found only when women with high serum anti-thyroid antibody values were included in the analysis; with 17.4% prevalence of sHT in women older than 75 years (Wickham study). Accordingly, in a Dutch study the prevalence of sHT in a group of middle-aged women (mean age 55 years) was 4%, the rate rising to 7.3% 10 years later (Geul et al, 1993). The higher prevalence of sHT in older people was confirmed by data from the Framingham Study, which reported a prevalence of sHT of 8.2% in men and 16.9% in women, older than 60 years and, the Colorado study (16% in men and 21% in women older than 74 yrs) (Sawin et al, 1979, Canaris et al, 2000.…”

Assessment of Thyroid Function among the individuals of tea garden community of Assam: A Hospital based Study.

“…In subclinical hypothyroidism TSH levels are elevated and the total or free T4 and T3 values are normal. The overall prevalence of subclinical hypothyroidism has been reported in the range of 4-10% in large general population screening surveys (Tunbridge et al, 1977;Canaris et al, 2000;Hollowell et al, 1999;Geul et al, 1993;Rivolta et al, 1999) and from 7-26% in studies of the upper age groups (Tunbridge et al,1977;Canaris et al, 2000;Hollowell et al, 1999;Bagchi et al, 1990;Sawin et al, 1979;Lindeman et al, 1999;Hak et al, 2000;Rosenthal et al, 1987;Parle et al, 1991). Central hypothyroidism is an another type of hypothyroidism, which is characterized by a defect of thyroid hormone production due to insufficient stimulation by TSH of an otherwise normal thyroid gland (Hak et al, 2000;Rosenthal et al, 1987;Parle et al, 1991;Yamada and Mori 2008).…”