The importance of transcriptomics and proteomics for studying molecular mechanisms of mycotoxin exposure: A review

Deoxynivalenol Induces Blood–Testis Barrier Dysfunction through Disrupting p38 Signaling Pathway-Mediated Tight Junction Protein Expression and Distribution in Mice

“…4 The raw materials of feed and human food sources contaminated with DON can easily enter the food chain, thus posing a severe threat to human health. 3 It is difficult to eliminate DON in food processing owing to its resistance to heat, pressure, and acids. 5,6 Recent evaluations based on urinary levels of DON as a biomarker show that approximately 80% of the population have been exposed to DON.…”

“…Deoxynivalenol (DON), one of the most common mycotoxins, is a secondary metabolite excreted by Fusarium spp . It is often present in agricultural and food products in the food supply chain. , In recent years, due to various environmental factors and other influences, contamination by DON is becoming a serious problem worldwide, and its concentration in contaminated grains is as high as 3800–6500 μg/kg in North America . The raw materials of feed and human food sources contaminated with DON can easily enter the food chain, thus posing a severe threat to human health .…”

“…It is often present in agricultural and food products in the food supply chain. , In recent years, due to various environmental factors and other influences, contamination by DON is becoming a serious problem worldwide, and its concentration in contaminated grains is as high as 3800–6500 μg/kg in North America . The raw materials of feed and human food sources contaminated with DON can easily enter the food chain, thus posing a severe threat to human health . It is difficult to eliminate DON in food processing owing to its resistance to heat, pressure, and acids. , Recent evaluations based on urinary levels of DON as a biomarker show that approximately 80% of the population have been exposed to DON. , DON exposure can lead to widespread organ toxicity upon entering the systemic circulation. − Recent studies show that DON can enter testicular tissues and cause testicular damage, resulting in infertility in males. , …”

The Protective Effect of Pumpkin and Fermented Whey Mixture against AFB1 and OTA Immune Toxicity In Vitro. A Transcriptomic Approach

“…In addition, NGS technology can be employed to gain further insight into cell responses, gene expression changes, and signaling pathways activation related to specific contaminants. [30,31] Therefore, the aim of the present study was to evaluate the potential effect of P-FW mixture against AFB1 and OTA promoted immune toxicity at transcriptional level in human lymphoblastic Jurkat cells by using digested bread extracts.…”

Rapid and Simultaneous Detection of Aflatoxin B1, Zearalenone, and T-2 Toxin in Medicinal and Edible Food Using Gold Immunochromatographic Test Strip

“…[5][6][7]. The main toxicity of mycotoxins is carcinogenic, teratogenic, genotoxic, immunotoxic, cytotoxic, etc., which can damage the liver, kidney, nerve tissue, hematopoietic tissue, and skin tissue of humans and animals, thereby causing acute or chronic poisoning of the body [8][9][10]. At present, there is no specific drug for the treatment of mycotoxins, because mycotoxins can contaminate a variety of complex matrices, and can show toxicity at low dose levels, so reliable and sensitive detection methods are required, so it is particularly important to monitor and inspect the contamination of food and traditional Chinese medicines and rescue contaminated food and traditional Chinese medicine.…”