The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis

Yan, Yi; He, Fei; Li, Zhonghao; Xu, Ruoting; Li, Ting; Su, Jinyu; Liu, Xianyan; Zhao, Ming; Wu, Wei

doi:10.1016/j.atherosclerosis.2018.11.016

Cited by 18 publications

(21 citation statements)

References 26 publications

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“…In the present study Ezetimibe did not affect ABCA1, ABCG5, ABCG8 and NPC1L1 relative gene expression; similarly a study in hamster measured protein expression of ABCG5, ABCG8, and NPC1L1 showed no change with ezetimibe treatment (During et al, 2005;Naples et al, 2012), While these genes were described to be down-regulated by Ezetimibe in caco 2 cells (During et al, 2005). A recent study showed that Ezetimibe may not only prevent atherosclerosis by inhibiting cholesterol absorption in the intestine, but also by increasing the expression of Apolipoprotein A-II in hepatocytes (Yan et al, 2019). Study in Human showed in accordance with this hypothesis that Ezetimibe increased the efficiency of reverse cholesterol transport from rapidly mixing plasma and tissue cholesterol pools into the stool (Lin et al, 2017).…”

Section: Discussionmentioning

confidence: 95%

Ezetimibe Enhances Macrophage-to-Feces Reverse Cholesterol Transport in Golden Syrian Hamsters Fed a High-Cholesterol Diet

Chadli

Tréguier

Briand

et al. 2020

The Journal of Pharmacology and Experimental Therapeutics

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Section: Discussionmentioning

confidence: 95%

Ezetimibe Enhances Macrophage-to-Feces Reverse Cholesterol Transport in Golden Syrian Hamsters Fed a High-Cholesterol Diet

Chadli

Tréguier

Briand

et al. 2020

The Journal of Pharmacology and Experimental Therapeutics

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“…In addition, ezetimibe promotes the expression of apolipoprotein A-II through the HNF4 and PPARα transcription factor in the HCD model (Yan et al, 2019). However, ezetimibe did not inhibit vascular lipid accumulation or macrophage recruitment induced by HCD when apolipoprotein A-II was knocked out, implying that apolipoprotein A-II plays a pivotal role in reducing AS caused by HCD (Yan et al, 2019). The effects of several drugs, including atorvastatin, fenofibrate and ezetimibe, on the cholesterol levels in HCD-fed zebrafish model have been investigated (Chen et al, 2017).…”

Section: Mechanistic Study Of Therapeutic Intervention and Drug Screementioning

confidence: 98%

“…The overexpression of apolipoprotein A-I binding protein (AIBP) mitigates diet-induced metabolic abnormalities, reducing diet-induced lipid accumulation in zebrafish blood vessels, and showing a protective effect from AS (Schneider et al, 2018). In addition, ezetimibe promotes the expression of apolipoprotein A-II through the HNF4 and PPARα transcription factor in the HCD model (Yan et al, 2019). However, ezetimibe did not inhibit vascular lipid accumulation or macrophage recruitment induced by HCD when apolipoprotein A-II was knocked out, implying that apolipoprotein A-II plays a pivotal role in reducing AS caused by HCD (Yan et al, 2019).…”

Section: Mechanistic Study Of Therapeutic Intervention and Drug Screementioning

confidence: 99%

Recent Application of Zebrafish Models in Atherosclerosis Research

Tang

Geng

et al. 2021

Front. Cell Dev. Biol.

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Atherosclerotic cardiovascular disease is one of the leading causes of death worldwide. Establishing animal models of atherosclerosis is of great benefit for studying its complicated pathogenesis and screening and evaluating related drugs. Although researchers have generated a variety of models for atherosclerosis study in rabbits, mice and rats, the limitations of these models make it difficult to monitor the development of atherosclerosis, and these models are unsuitable for large scale screening of potential therapeutic targets. On the contrast, zebrafish can fulfill these purposes thanks to their fecundity, rapid development ex utero, embryonic transparency, and conserved lipid metabolism process. Thus, zebrafish have become a popular alternative animal model for atherosclerosis research. In this mini review, we summarize different zebrafish models used to study atherosclerosis, focusing on the latest applications of these models to the dynamic monitoring of atherosclerosis progression, mechanistic study of therapeutic intervention and drug screening, and assessment of the impacts of other risk factors.

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“…zgc:55461 was another gene that was downregulated in both FR70 and FR85 fish, which is predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle [45]. Commonly upregulated genes from FR70 and FR85 groups include the apoa1b gene, which is predicted to be involved in cholesterol binding, phosphatidylcholine-sterol Oacyltransferase activator, and phospholipid binding activity [46]. Another gene that was upregulated was c6ast1.…”

Section: Rna Sequencing-based Transcriptomic Profilingmentioning

confidence: 99%

Feed Restriction Modulates Growth, Gut Morphology and Gene Expression in Zebrafish

Purushothaman

Tan

Lau

et al. 2021

IJMS

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A reduction in daily caloric or nutrient intake has been observed to promote health benefits in mammals and other vertebrates. Feed Restriction (FR), whereby the overall food intake of the organism is reduced, has been explored as a method to improve metabolic and immune health, as well as to optimize productivity in farming. However, less is known regarding the molecular and physiological consequences of FR. Using the model organism, Danio rerio, we investigated the impact of a short-term (month-long) FR on growth, gut morphology and gene expression. Our data suggest that FR has minimal effects on the average growth rates, but it may affect weight and size heterogeneity in a sex-dependent manner. In the gut, we observed a significant reduction in gut circumference and generally lower mucosal heights, whereas other parameters remained unchanged. Gene Ontology (GO), EuKaryotic Orthologous Groups (KOG), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis identified numerous metabolic, reproductive, and immune response pathways that were affected by FR. These results broaden our understanding of FR and contribute towards growing knowledge of its effects on vertebrate health.

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The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis

Cited by 18 publications

References 26 publications

Ezetimibe Enhances Macrophage-to-Feces Reverse Cholesterol Transport in Golden Syrian Hamsters Fed a High-Cholesterol Diet

Ezetimibe Enhances Macrophage-to-Feces Reverse Cholesterol Transport in Golden Syrian Hamsters Fed a High-Cholesterol Diet

Recent Application of Zebrafish Models in Atherosclerosis Research

Feed Restriction Modulates Growth, Gut Morphology and Gene Expression in Zebrafish

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