The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

Cao, Peng; Wu, Sanlan; Wu, Tingting; Deng, Yahui; Zhang, Qilin; Wang, Kaiping; Yu, Zhang

doi:10.1016/j.carbpol.2020.116346

Cited by 92 publications

(66 citation statements)

References 120 publications

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“…In contrast, fewer critical patients were treated with a traditional Chinese medicine, the Lung Cleansing and Detoxifying Decoction, which is an extraction from a mixture of 21 herbal plants. Our data support a protective role of this therapy for COVID-19 [11].…”

Section: Treatments and Outcomessupporting

confidence: 81%

Risk factors for the critical illness in SARS-CoV-2 infection: a multicenter retrospective cohort study

Cheng

et al. 2020

Preprint

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Background: Prior studies reported that 5~32% COVID-19 patients were critically ill, a situation that poses great challenge for the management of the patients and ICU resources. We aim to identify independent risk factors to serve as prediction markers for critical illness of SARS-CoV-2 infection. Methods : Fifty-two critical and 200 non-critical SARS-CoV-2 nucleic acid positive patients hospitalized in 15 hospitals outside Wuhan from January 19 to March 6, 2020 were enrolled in this study. Multivariable logistic regression and LASSO logistic regression were performed to identify independent risk factors for critical illness.Results: Age older than 60 years, dyspnea, respiratory rate > 24 breaths per min, leukocytosis >9.5 X109/L, neutrophilia >6.3 X109/L, lymphopenia <1.1 X109/L, neutrophil-to-lymphocyte ratio >3.53, fibrinogen >4g/L, d-dimer >0.55 µg/mL, blood urea nitrogen >7.1 mM, elevated aspartate transaminase, elevated alanine aminotransferase, total bilirubin >21 µM, and Sequential Organ Failure Assessment (SOFA) score ≥2 were identified as risk factors for critical illness. LASSO logistic regression identified the best combination of risk factors as SOFA score, age, dyspnea, and leukocytosis. The Area Under the Receiver-Operator Curve values for the risk factors in predicting critical illness were 0.921 for SOFA score, 0.776 for age, 0.764 for dyspnea, 0.658 for leukocytosis, and 0.960 for the combination of the four risk factors.Conclusions: Our findings advocate the use of risk factors SOFA score ≥2, age >60, dyspnea and leukocytosis >9.5 X109/L on admission, alone or in combination, to determine the optimal management of the patients and health care resources.

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Section: Treatments and Outcomessupporting

confidence: 81%

Risk factors for the critical illness in SARS-CoV-2 infection: a multicenter retrospective cohort study

Cheng

et al. 2020

Preprint

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“…Encouragingly, the NHC (National Health Commission of People’s Republic of China) recently issued a statement that several Chinese medicine formulas were suggested curing the patients in the early stage of infections. Of note, more and more patients were discharged from hospital after being cured by integrated treatment by combining Chinese with Western medicine in China ( Cao et al, 2020 ; Qiu et al, 2020 ). In addition, it also should be mentioned that many Chinese herbal formulas such as Le-Cao-Shi, JieZe-1, and San Wu Huang Qin decoctions were used to prevent virus infection and cure the viral diseases in China ( Ma et al, 2018 ; Zhao et al, 2019 ; Duan et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Discovery of Potential Flavonoid Inhibitors Against COVID-19 3CL Proteinase Based on Virtual Screening Strategy

Yang

Zhang

et al. 2020

Front. Mol. Biosci.

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The outbreak of 2019 novel coronavirus (COVID-19) has caused serious threat to public health. Discovery of new anti-COVID-19 drugs is urgently needed. Fortunately, the crystal structure of COVID-19 3CL proteinase was recently resolved. The proteinase has been identified as a promising target for drug discovery in this crisis. Here, a dataset including 2030 natural compounds was screened and refined based on the machine learning and molecular docking. The performance of six machine learning (ML) methods of predicting active coronavirus inhibitors had achieved satisfactory accuracy, especially, the AUC (Area Under ROC Curve) scores with fivefold cross-validation of Logistic Regression (LR) reached up to 0.976. Comprehensive ML prediction and molecular docking results accounted for the compound Rutin, which was approved by NMPA (National Medical Products Administration), exhibited the best AUC and the most promising binding affinity compared to other compounds. Therefore, Rutin might be a promising agent in anti-COVID-19 drugs development.

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“…Therefore, an understanding of the cytokine storm that aggravates ARDS in COVID-19 may lead to early and effective intervention in critically-ill COVID-19 patients. It seems necessary to directly inhibit inflammatory response in the lungs because cytokine storm can be alleviated with inflammatory therapy ( Cao P. et al, 2020 ). Previous studies have shown the benefits of anti-inflammatory drugs in lung disease: they slow down impairment of lung function, reverse the inflammatory parameters nearly back to normal values, and improve patients’ survival ( Konstan et al, 2011 ; Lubamba et al, 2011 ).…”

Section: Bioactive Volatile Components Of Dayuan-yinmentioning

confidence: 99%

The Important Role of Volatile Components From a Traditional Chinese Medicine Dayuan-Yin Against the COVID-19 Pandemic

Zhang

Ren

et al. 2020

Front. Pharmacol.

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Aromatic Chinese herbs have been used to prevent plagues since ancient times. Traditional Chinese medicine has unique advantages in the prevention and treatment of epidemic diseases. According to the traditional Chinese medicine treatment plan in the National COVID-19 Diagnosis and Treatment Plan (Trial Seventh Edition) of the National Health Commission, Chinese patent medicines or prescriptions rich in aromatic Chinese herbs are selected for prevention and treatment during the period of medical observation, clinical treatment, and recovery of confirmed COVID-19 patients. Some local health committees or traditional Chinese medicine administrations recommend a variety of other ways of using traditional aromatic Chinese herbs to prevent and cure COVID-19. These involve external fumigation, use of moxibustion, and wearing of sachet. The efficacy of aromatic Chinese herbs plays a decisive role in the prevention and treatment of COVID-19. The unique properties, chemical composition, and mechanism of action of aromatic Chinese herbs are worthy of extensive and in-depth experimental and clinical research. The findings are expected to provide a reference for follow-up treatment of novel coronavirus and the development of corresponding drugs. In 2003, Dayuan-Yin produced excellent results in the treatment of the SARS virus. Individually, 112 confirmed cases were administered this drug between January and April 2003, and more than 93.7% of the patients showed noticeable mitigation of the symptoms, as well as recovery. Dayuan-Yin also was selected as one of the nationally recommended prescriptions for the COVID-19. Based on the national recommendation of Dayuan-Yin prescription, this review discusses the role of volatile components in the prevention and treatment of COVID-19, and speculates the possible mechanism of action, so as to provide a basis for the prevention and treatment of COVID-19.

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The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

Cited by 92 publications

References 120 publications

Risk factors for the critical illness in SARS-CoV-2 infection: a multicenter retrospective cohort study

Risk factors for the critical illness in SARS-CoV-2 infection: a multicenter retrospective cohort study

Discovery of Potential Flavonoid Inhibitors Against COVID-19 3CL Proteinase Based on Virtual Screening Strategy

The Important Role of Volatile Components From a Traditional Chinese Medicine Dayuan-Yin Against the COVID-19 Pandemic

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