The improved inhibition of Mn (II)-EGCG on α-glucosidase: Characteristics and interactions properties

Li, Zhenru; Kang, Mengchen; Zhang, Shuangling; Zhang, Suzhi; Dongye, Zixuan; Wang, Li; Chen, Chengwang; Cheng, Xiaofang; Qian, Yaru; Ren, Yuhang

doi:10.1016/j.molstruc.2023.135314

Cited by 6 publications

(2 citation statements)

References 49 publications

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“…The IC 50 obtained for EGCG is the equivalent of 20.13 ± 1.33 µM (9.23 ± 0.61 µg/mL). Similar results were obtained by Xu et al and Li et al 47 , 48 Other studies mentioned slightly higher values of IC 50 for EGCG, 49 , 50 however in all cases EGCG proved a three to five times better inhibition of α-glucosidase compared to acarbose, which is a standard prescribed anti-diabetic drug that inhibits α-glucosidase activity. Even though catechin derivatives are known for their inhibition of α-glucosidase, other polyphenols, like chlorogenic acid or rutin, also show inhibitory activity of α-glucosidase, 51 , 52 so these might contribute to the antidiabetic activity of the prepared WB extract as well.…”

Section: Resultssupporting

confidence: 85%

Design of Scaffolds Based on Zinc-Modified Marine Collagen and Bilberry Leaves Extract-Loaded Silica Nanoparticles as Wound Dressings

Deaconu,

Prelipcean,

Brezoiu

et al. 2024

IJN

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Purpose In this study, wound dressings were designed using zinc-modified marine collagen porous scaffold as host for wild bilberry (WB) leaves extract immobilized in functionalized mesoporous silica nanoparticles (MSN). These new composites were developed as an alternative to conventional wound dressings. In addition to the antibacterial activity of classic antibiotics, a polyphenolic extract could act as an antioxidant and/or an anti-inflammatory agent as well. Methods Wild bilberry leaves extract was prepared by ultrasound-assisted extraction in ethanol and its properties were evaluated by UV-Vis spectroscopy (radical scavenging activity, total amount of polyphenols, flavonoids, anthocyanins, and condensed tannins). The extract components were identified by HPLC, and the antidiabetic properties of the extract were evaluated via α-glucosidase inhibitory activity. Spherical MSN were modified with propionic acid or proline moieties by post-synthesis method and used as carriers for the WB leaves extract. The textural and structural features of functionalized MSN were assessed by nitrogen adsorption/desorption isotherms, small-angle XRD, SEM, TEM, and FTIR spectroscopy. The composite porous scaffolds were prepared by freeze drying of the zinc-modified collagen suspension containing WB extract loaded silica nanoparticles. Results The properties of the new composites demonstrated enhanced properties in terms of thermal stability of the zinc-collagen scaffold, without altering the protein conformation, and stimulation of NCTC fibroblasts mobility. The results of the scratch assay showed contributions of both zinc ions from collagen and the polyphenolic extract incorporated in functionalized silica in the wound healing process. The extract encapsulated in functionalized MSN proved enhanced biological activities compared to the extract alone: better inhibition of P. aeruginosa and S. aureus strains, higher biocompatibility on HaCaT keratinocytes, and anti-inflammatory potential demonstrated by reduced IL-1β and TNF-α levels. Conclusion The experimental data shows that the novel composites can be used for the development of effective wound dressings.

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Section: Resultssupporting

confidence: 85%

Design of Scaffolds Based on Zinc-Modified Marine Collagen and Bilberry Leaves Extract-Loaded Silica Nanoparticles as Wound Dressings

Deaconu,

Prelipcean,

Brezoiu

et al. 2024

IJN

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“…Zhen et al studied the bioactivity of an Mn(II)-EGCG complex, which disclosed that the Mn-EGCG complex expressed a high inhibition rate on a-glucosidase. 14 But it is noteworthy that manganese is not regarded as a preferred metal ion for enhancing the properties of EGCG, because Mn(II) shows some serious toxicity to organisms, and the excessive accumulation of Mn 2+ may lead to severe damage to human health. It has been shown that the activities of numerous enzymes targeted by polyphenols are dependent on zinc, and polyphenols can transport zinc cations through the plasma membrane as zinc ionophores.…”

Section: Introductionmentioning

confidence: 99%

Improved antioxidative and antibacterial activity of epigallocatechin gallate derivative complexed by zinc cations and chitosan

Zhao,

Qian,

Zhang

et al. 2024

RSC Adv.

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Construction and characterization of Zn-WPH-COS complex nanoparticles with improved zinc bioavailability

Cheng,

Zhang,

Qian

et al. 2024

Food Chemistry

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The improved inhibition of Mn (II)-EGCG on α-glucosidase: Characteristics and interactions properties

Cited by 6 publications

References 49 publications

Design of Scaffolds Based on Zinc-Modified Marine Collagen and Bilberry Leaves Extract-Loaded Silica Nanoparticles as Wound Dressings

Design of Scaffolds Based on Zinc-Modified Marine Collagen and Bilberry Leaves Extract-Loaded Silica Nanoparticles as Wound Dressings

Improved antioxidative and antibacterial activity of epigallocatechin gallate derivative complexed by zinc cations and chitosan

Construction and characterization of Zn-WPH-COS complex nanoparticles with improved zinc bioavailability

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