The in vitro anthelmintic properties of browse plant species against Haemonchus contortus is determined by the polyphenol content and composition

Mengistu, Genet; Hoste, Hervé; Karonen, Maarit; Salminen, Juha‐Pekka; Hendriks, W.H.; Pellikaan, W.F.

doi:10.1016/j.vetpar.2016.12.020

Cited by 47 publications

(39 citation statements)

References 33 publications

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“…Taken together, these observations could explain why PDs, which generally have larger mDP values than PCs, have better anthelmintic properties Kommuru et al, 2014Kommuru et al, , 2015. Given the low uptake (bioavailability) of polymeric CTs in mammalian tissues in comparison with monomeric flavonoids (Li and Hagerman, 2013), it would be worth exploring whether the internal tissue damage arises from the CTs or from other compounds that may be present in plant extracts (Brunet and Hoste, 2006;Williams et al, 2015;Klongsiriwet et al, 2015;Desrues et al, 2016a;Mengistu et al, 2017). leaves (Martínez-Ortíz-de-Montellano et al, 2013;Kommuru et al, 2015).…”

Section: Mechanisms Of Antiparasitic Condensed Tannin Actionmentioning

confidence: 99%

“…Scanning and transmission electron microscopy detected not only external but also internal damage to the cuticle and sensilla of the lip region of young and adult Caenorhabditis elegans by different CT types, and to the cuticle and underlying tissue (i.e., muscle cells) and intestinal cells of H. contortus L3 larvae and adults and of T. colubriformis L3 larvae by sainfoin and tzalam CTs (Brunet et al, 2011;Martínez-Ortíz-de-Montellano et al, 2013;Ropiak et al, 2016a). Given the low uptake (bioavailability) of polymeric CTs in mammalian tissues in comparison with monomeric flavonoids (Li and Hagerman, 2013), it would be worth exploring whether the internal tissue damage arises from the CTs or from other compounds that may be present in plant extracts (Brunet and Hoste, 2006;Williams et al, 2015;Klongsiriwet et al, 2015;Desrues et al, 2016a;Mengistu et al, 2017). It also raises the question whether mixtures of CTs plus co-occurring smaller plant compounds (such as quercetin, luteolin, cinnamaldehyde, etc.)…”

Section: Mechanisms Of Antiparasitic Condensed Tannin Actionmentioning

confidence: 99%

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Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition

et al. 2019

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Condensed tannins (CTs) account for up to 20% of the dry matter in forage legumes used as ruminant feeds. Beneficial animal responses to CTs have included improved growth, milk and wool production, fertility, and reduced methane emissions and ammonia volatilization from dung or urine. Most important is the ability of such forages to combat the effects of gastrointestinal parasitic nematodes. Inconsistent animal responses to CTs were initially attributed to concentration in the diet, but recent research has highlighted the importance of their molecular structures, as well as concentration, and also the composition of the diet containing the CTs. The importance of CT structural traits cannot be underestimated. Interdisciplinary research is the key to unraveling the relationships between CT traits and bioactivities and will enable future on‐farm exploitation of these natural plant compounds. Research is also needed to provide plant breeders with guidelines and screening tools to optimize CT traits, in both the forage and the whole diet. In addition, improvements are needed in the competitiveness and agronomic traits of CT‐containing legumes and our understanding of options for their inclusion in ruminant diets. Farmers need varieties that are competitive in mixed swards and have predictable bioactivities. This review covers recent results from multidisciplinary research on sainfoin (Onobrychis Mill. spp.) and provides an overview of current developments with several other tanniniferous forages. Tannin chemistry is now being linked with agronomy, plant breeding, animal nutrition, and parasitology. The past decade has yielded considerable progress but also generated more questions—an enviable consequence of new knowledge!

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Section: Mechanisms Of Antiparasitic Condensed Tannin Actionmentioning

confidence: 99%

Section: Mechanisms Of Antiparasitic Condensed Tannin Actionmentioning

confidence: 99%

Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition

et al. 2019

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“…African browse plant extracts showed high LEI activity, resulting from the presence of both phenolic and non-phenolic compounds. The concentration of condensed tannins was not necessarily related to the anthelmintic properties of the extracts against L3 H. contortus (Mengistu et al, 2017).…”

Section: Discussionmentioning

confidence: 83%

Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 1: in vitro inhibition of the hatchability and larval development

et al. 2019

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“…An alternative that has attained some attention is the inclusion of medicinal plants in the diet of animals. Several researchers have tested the plants used in folk medicine, evaluating their efficacy and safety through in vitro assays (FÉBOLI et al, 2016;MENGISTU et al, 2017;OLIVEIRA et al, 2017) at various stages of parasites' lives and in vivo with naturally infected and artificially infected sheep (KANOJIYA et al, 2015;KATIKI et al, 2017;BARONE et al, 2018). The anthelmintic properties of the plants are generally related to the presence of phytoconstituents such as tannins, flavonoids and saponins, which are present in larger amounts than other components.…”

Section: Introductionmentioning

confidence: 99%

“…The anthelmintic properties of the plants are generally related to the presence of phytoconstituents such as tannins, flavonoids and saponins, which are present in larger amounts than other components. Some authors report that the activity observed in these plants may be related to the existence of synergism between tannins and saponins (HERNÁNDEZ-VILLEGAS et al, 2011;MARIE-MAGDELEINE et al, 2014;MENGISTU et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

In vitro ovicidal and larvicidal activity of Psidium cattleianum Sabine leaves against gastrointestinal nematodes of naturally infected sheep

Piza¹,

Féboli²,

Augusto³

et al. 2019

Bol. Ind. Anim.

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Gastrointestinal nematodes can affect sheep productivity via severe weight loss, anemia and death. Infection control is generally performed with synthetic anthelmintic compounds; however, indiscriminate use of these drugs can stimulate the emergence of resistant nematodes. Thus, alternatives to the use of synthetic anthelmintic compounds have been proposed, such as the inclusion of medicinal plants in animal feed. The objective of this study was evaluate the anthelmintic activity of the leaves of the medicinal plant Psidium cattleianum Sabine (Araçá) through its hydroalcoholic extract, and using in vitro assays with the eggs and larvae of gastrointestinal nematodes obtained from naturally infected donor sheep. The extract exhibited good in vitro ovicidal and larvicidal activity, with IC 50 values of 0.55 mg mL-1 for egg hatching inhibition, 0.20 mg mL-1 for larval development inhibition and an efficiency greater than 80% in the inhibition of larval migration at all concentrations evaluated (IC 50 < 0.19 mg/mL). Phytochemical analysis detected higher concentrations of saponins, flavonoids, cardiac glycosides, anthraquinones and tannins in the extract. Our results demonstrated that the Psidium cattleianum Sabine's leaves exhibit in vitro anthelmintic activity, which suggests that in addition to its other medicinal properties, this plant can help control gastrointestinal nematodes in sheep. Future in vivo assays should be performed to confirm antiparasitic efficacy.

show abstract

The in vitro anthelmintic properties of browse plant species against Haemonchus contortus is determined by the polyphenol content and composition

Cited by 47 publications

References 33 publications

Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition

Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition

Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 1: in vitro inhibition of the hatchability and larval development

In vitro ovicidal and larvicidal activity of Psidium cattleianum Sabine leaves against gastrointestinal nematodes of naturally infected sheep

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