The in vitro antimicrobial activity of silicone oils used in ophthalmic surgery

Chrapek, O; Večeřová, Renata; Koukalová, Dagmar; Marešová, K; Jirková, B; Šín, Martin; Řehák, J

doi:10.5507/bp.2011.060

Cited by 13 publications

(18 citation statements)

References 33 publications

(33 reference statements)

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“…Interestingly, fungal organisms were not identified histologically in the posterior segment, suggesting a possible antimicrobial effect of silicone oil after surgery. In fact, previous reports have confirmed that using silicone oil in these complicated cases is appropriate because it does not support the growth of microbes, including both bacterial and fungal isolates 11. Furthermore, it helps reduce rates of subsequent retinal detachments and may help stabilize progression of hypotony 12.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic correlation of Aspergillus endophthalmitis following uncomplicated cataract surgery

Haddock¹,

Flynn²,

Dubovy³

et al. 2012

OPTH

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A clinicopathologic correlation between two patients with acute-onset Aspergillus endophthalmitis undergoing enucleation is reported. These two patients presented with pain, redness, and decreased vision following uncomplicated cataract surgery. In both patients, vitreous aspiration and intravitreal injections were the initial treatment followed later by pars plana vitrectomy for clinical worsening. Despite repeated surgical and medical interventions, the clinical course of both patients was prolonged, unsuccessful, and resulted in enucleation for a blind painful eye. Histologic examination of the enucleated specimens showed that, in spite of prolonged local and systemic therapy, there was persistent diffuse infiltration of the anterior chamber and ciliary body by a filamentous mold.

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Section: Discussionmentioning

confidence: 99%

Histopathologic correlation of Aspergillus endophthalmitis following uncomplicated cataract surgery

Haddock¹,

Flynn²,

Dubovy³

et al. 2012

OPTH

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“…35 Previous reports suggested that using silicone oil could prevent the growth of microbes, including bacterial and fungal isolates. 54 Furthermore, it helps reduce rates of complications, like retinal detachments or hypotony. 55 Nevertheless, it was recently assessed that silicone oil might play a weaker role in antifungal therapy; 56 furthermore, nontoxic concentrations of intravitreal drugs could create toxicity in a silicone oil-filled eye.…”

Section: Surgerymentioning

confidence: 99%

<p>Diagnostic and Management Strategies of Aspergillus Endophthalmitis: Current Insights</p>

Spadea¹,

Giannico²

2019

OPTH

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Fungal endophthalmitis is subsequent to endogenous or exogenous infection and represents an important complication of ocular surgery which may lead to significant visual loss and blindness. The prognosis is poor because of delayed diagnosis and limited availability of effective antifungal drugs with good ocular penetration. Furthermore, the critical issue in diagnosing fungal infection of the eye is microbiological identification of the etiologic agent in clinical samples. Aspergillus is among the most frequent isolated organisms in fungal endophthalmitis. Early diagnosis is essential to prevent severe complications and blindness. Treatments include local, systemic and surgical therapeutic strategies. The purpose of the present review is the analysis of the current procedures adopted to promptly diagnose and treat Aspergillus endophthalmitis.

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“…Unsere Ergebnisse decken sich mit den dafür in der Literatur berichteten schlechten postoperativen Ergebnissen nach IVOM mit Visus < 0,1 in über 70 % der Fälle aufgrund von PVR-Ablatio, Anstieg des Augeninnendrucks und Optikusatrophie [13]. In der Literatur wird eine Silikonöltamponade als protektiv und antibakteriell wirksam beschrieben [14]. Retrospektive Studien zeigen bei postoperativen Fällen von Endophthalmitis nach IVOM bei primärer Silikonöltamponade ein besseres funktionelles Ergebnis mit weniger PVR-Ablatio im Verlauf [15,16] [21].…”

Section: Therapie/mikrobiologieunclassified

Verlauf der postoperativen Endophthalmitis nach Kataraktchirurgie und intravitrealer operativer Medikamenteneingabe (IVOM) – eine 5-Jahres-Analyse

Michel

Häberle

Pham

2014

Klin Monatsbl Augenheilkd

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The in vitro antimicrobial activity of silicone oils used in ophthalmic surgery

Cited by 13 publications

References 33 publications

Histopathologic correlation of Aspergillus endophthalmitis following uncomplicated cataract surgery

Histopathologic correlation of Aspergillus endophthalmitis following uncomplicated cataract surgery

<p>Diagnostic and Management Strategies of Aspergillus Endophthalmitis: Current Insights</p>

Verlauf der postoperativen Endophthalmitis nach Kataraktchirurgie und intravitrealer operativer Medikamenteneingabe (IVOM) – eine 5-Jahres-Analyse

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