The in-vitro bioactivity of mesoporous bioactive glasses

Yan, Xiaoxia; Huang, Xiaohui; Yu, Chengzhong; Deng, Hexiang; Wang, Yi; Zhang, Zhendong; Qiao, Shi Zhang; Lu, Gao Qing; Zhao, Dongyuan

doi:10.1016/j.biomaterials.2006.01.043

Cited by 338 publications

(251 citation statements)

References 25 publications

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“…The level of silica from 100S and its release rate were both higher than previously reported, at any given time point [25,50,51]. It is likely to be due to the lower stabilisation temperature used here.…”

Section: Effect Of the Crystallisation On The In Vitro Performancecontrasting

confidence: 59%

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Maçon

Jacquemin

Page

et al. 2016

J Sol-Gel Sci Technol

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This work reports the synthesis of lithium-silicate glass, containing 10 mol% of Li 2 O by the sol-gel process, intended for the regeneration of cartilage. Lithium citrate and lithium nitrate were selected as lithium precursors. The effects of the lithium precursor on the sol-gel process, and the resulting glass structure, morphology, dissolution behaviour, chondrocyte viability and proliferation, were investigated. When lithium citrate was used, mesoporous glass containing lithium as a network modifier was obtained, whereas the use of lithium nitrate produced relatively dense glass-ceramic with the presence of lithium metasilicate, as shown by X-ray diffraction, 29 Si and 7 Li MAS NMR and nitrogen sorption data. Nitrate has a better affinity for lithium than citrate, leading to heterogeneous crystallisation from the mesopores, where lithium salts precipitated during drying. Citrate decomposed at a lower temperature, where the crystallisation of lithium-silicate crystal is not thermodynamically favourable. Upon decomposition of the citrate, a solid-state salt metathesis reaction between citrate and silanol occurred, followed by the diffusion of lithium within the structure of the glass. Both glass and glass-ceramic released silica and lithium ions in culture media, but release rate was lower for the glass-ceramic. Both samples did not affect chondrocyte viability and proliferation.Graphical Abstract

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Section: Effect Of the Crystallisation On The In Vitro Performancecontrasting

confidence: 59%

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Maçon

Jacquemin

Page

et al. 2016

J Sol-Gel Sci Technol

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“…Therefore, several scientific 187 reports have shown that different parameters 188 involved in the synthesis of OMS, such as silica 189 source, pH, temperature, surfactant removal proce-190 dure (calcination or solvent extraction), strongly 191 influence the silica degradation rate in physiological 192 media [40]. In this sense, it has been reported that doping OMS 205 with different calcium oxide amounts helps to obtain 206 an adaptable degradation performance [41][42][43][44]. In 207 addition, the presence of CaO as network modifier is 208 also a very important factor for the bioactivity pro-209 cess, i.e.…”

Section: Network Condensation Degreementioning

confidence: 99%

Tuning mesoporous silica dissolution in physiological environments: a review

et al. 2017

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19Matrix degradation has a major impact on the release kinetics of drug delivery 20 systems. Regarding ordered mesoporous silica materials for biomedical appli-21 cations, their dissolution is an important parameter that should be taken into 22 consideration. In this paper, we review the main factors that govern the 23 mesoporous silica dissolution in physiological environments. We also provide 24 the necessary knowledge to researchers in the area for tuning the dissolution 25 rate of those matrices, so the degradation could be controlled and the material 26 behaviour optimised. 27 28 29 Introduction 30 Ordered mesoporous silica materials (OMS) have 31 received great attention by the biomedical scientific 32 community since they were proposed for the first 33 time as drug delivery systems by the research group 34 headed by Vallet-Regí et al. [1]. Their unique struc-35 tural and textural properties, such as tuneable pore 36 structure, large surface area and pore volume, con-37 trollable pore diameter and morphology, and func-38 tionalisable surface, make OMS excellent candidates 39 to be applied as drug delivery devices in different 40 biomedical applications [2][3][4][5]. 41Initially, OMS were purposed as bioceramics for 42 local drug delivery and bone tissue regenerations due 43 to their surface characteristics, such as biocompati-44 bility and bioactivity, and their capability to load and 45 release in a controlled fashion different therapeutic 46 cargoes for the treatment of diverse pathologies 47 (Fig. 1,t o (Fig. 1, bottom), 56 underlining their systemic administration as 57 nanocarriers for diagnosis and treatment of complex 58 diseases such as cancer [20][21][22][23][24][25]. 59 The degradability of different drug delivery devi-60 ces is a key parameter for their successful translation 61 to a clinical scenario. In this sense, dissolution has 62 profound implications in the mechanical properties 63 of materials used for bone filling. Most importantly,

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“…To improve the bioactivity of conventional bioactive glass for bone regeneration, Yan et al, 91,92 for the first time, prepared a new class of mesoporous bioactive glasses (MBG) in 2004 by the combination of the sol-gel method and supramolecular chemistry of surfactants. Their study has opened a new direction for applying nanotechniques to regenerative medicine by coupling drug delivery with bioactive materials.…”

Section: Nanotechnology In Bone Regenerationmentioning

confidence: 99%

“…Compared to conventional nonmesoporous bioactive glasses, the MBG possesses a more optimal surface area, pore volume, ability to induce in vitro apatite mineralization in simulated body fluids, and excellent cytocompatibility. [92][93][94][95] For better bone regeneration application, MBG can also be prepared as 3D porous scaffolds for bone tissue engineering and drug delivery applications. 96 Currently, there are three methods to prepare MBG scaffolds.…”

Section: Nanotechnology In Bone Regenerationmentioning

confidence: 99%

Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

Wu²,

Chen³

et al. 2013

IJN

166

111

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Nanotechnology is a vigorous research area and one of its important applications is in biomedical sciences. Among biomedical applications, targeted drug delivery is one of the most extensively studied subjects. Nanostructured particles and scaffolds have been widely studied for increasing treatment efficacy and specificity of present treatment approaches. Similarly, this technique has been used for treating bone diseases including bone regeneration. In this review, we have summarized and highlighted the recent advancement of nanostructured particles and scaffolds for the treatment of cancer bone metastasis, osteosarcoma, bone infections and inflammatory diseases, osteoarthritis, as well as for bone regeneration. Nanoparticles used to deliver deoxyribonucleic acid and ribonucleic acid molecules to specific bone sites for gene therapies are also included. The investigation of the implications of nanoparticles in bone diseases have just begun, and has already shown some promising potential. Further studies have to be conducted, aimed specifically at assessing targeted delivery and bioactive scaffolds to further improve their efficacy before they can be used clinically.

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The in-vitro bioactivity of mesoporous bioactive glasses

Cited by 338 publications

References 25 publications

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Tuning mesoporous silica dissolution in physiological environments: a review

Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

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