The In Vitro Effects of Isoflurane, Sevoflurane, and Propofol on Platelet Aggregation

Doğan, İsmet; Ovalı, Ercüment; Etı, Zeynep; Yaycı, Abdurrahman; Göğüş, F. Yılmaz

doi:10.1097/00000539-199902000-00039

Cited by 43 publications

(39 citation statements)

References 7 publications

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“…In an in vitro study performed on blood samples obtained from patients under general anesthesia, Dogan and colleagues showed that sevoflurane and propofol, but not isoflurane, possess significant inhibitory effects on platelet aggregation. 12 Similar results were also obtained by Hirakata et al as they demonstrated that in patients anesthetized with sevoflurane, but not isoflurane, secondary platelet aggregation could not be induced by adenosine diphosphate (ADP) and epinephrine. 13 However, the same group demonstrated in vitro that although isoflurane was less potent than halothane and enflurane, it could inhibit thromboxane A 2 induced platelet aggregation in a dose-dependent manner.…”

Section: Discussionsupporting

confidence: 71%

La technique anesthésique n’affecte pas la performance d’un modèle de réductions cycliques de flot chez le lapin : une étude pilote

Charbonneau

Girard

Boudreault

et al. 2007

Can J Anesth/J Can Anesth

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Purpose: Pentobarbital anesthesia is, typically, used in an experimental model of cyclic flow reductions (CFR) in rabbits. Our initial observations, using a more complete and effective isoflurane-based anesthetic technique, failed to reproduce findings reported previously. Consequently, we compared the effects of these two anesthetic techniques in the model. Methods:A modified Folts' model of carotid artery lesion and stenosis was used. Twelve rabbits completed the experimental protocol: five in the pentobarbital group (P) and seven in the isoflurane group (I). The carotid artery was exposed and flow was reduced by application of a clamp. A standardized injury was performed by cross clamping the artery with a needle forceps and this produced CFR. The number of CFR and the duration of their occurrence were noted. The incidence of thrombosis was compared in each group as well as hemodynamic, hematologic and bleeding time values. Results:The hematocrit value, platelet count and bleeding time were similar in both groups. The median number and range of CFR [group P: 9 (4-16) ; group I: 9 (5-14)] and the time span of effective CFR formation (group P: 39 ± 17; group I: 38 ± 25 min) were comparable in both groups. The incidence of complete thrombosis of the carotid artery was similar in both groups. Conclusions:The stability of the model is of short duration, but the occurrence of CFR is not affected by the type of anesthesia. Our findings suggest that the ideal duration of the experimental protocol should be between 30 and 45 min in order to maximize the number of animals still developing CFR. [groupe P : 9 (4-16) ; groupe I : 9 (5-14)] ainsi que la durée pendant laquelle les CFR avaient lieu (groupe P : 39 ±17 ; groupe I : 38 ± 25 min) Méthode : Un modèle de Folts modifié de lésion de l'artère carotide et de sténose a été utilisé. Douze lapins ont pris part au protocole expérimental : cinq dans le groupe pentobarbital (P), et sept dans le groupe isoflurane (I). L'artère carotide a été exposée et le

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Section: Discussionsupporting

confidence: 71%

La technique anesthésique n’affecte pas la performance d’un modèle de réductions cycliques de flot chez le lapin : une étude pilote

Charbonneau

Girard

Boudreault

et al. 2007

Can J Anesth/J Can Anesth

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“…Moreover, the same author states that the administration of propofol generates ht decreases between 4-7% of the value obtained after the MPA, results that corroborate those found in this study (3-7%). The isoflurane does not promote hematological changes during trans-and post-operative times (DOGAN et al, 1999). Although there were no hemogasometric evaluations, mechanical ventilation occurred without complications, and as Batista et al (2010) describe, it performed this function without deleterious effects on the cardiovascular system.…”

Section: Introductionmentioning

confidence: 89%

Influence of Ringer’s lactated solution in continuous infusion and general anesthesia on hematocrit in dogs

et al. 2015

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The measurement of serum parameters during general anesthesia procedures are subject to variations due to differences in protocol, splenic storage, and by the instituted fluid therapy. The aim of this study was to assess the hematocrit changes promoted by controlled fluid therapy and general anesthesia. Six mongrel female dogs underwent an anesthetic protocol with acepromazine (0.03 mg kg -1 ) and tramadol (5 mg kg -1 ) for premedication, induction with propofol (3 mg kg -1 ), and maintained with isoflurane and mechanical ventilation for 120 minutes. After induction, they were infused with 10 ml kg hr -1 of Ringer's lactate solution. Hematocrit measurements were performed from the start until 72 hours from anesthesia and evaluated statistically to check if there were significant changes over time. The fluid therapy, the acepromazine and propofol in the anesthetic protocol promotes a significant reduction of hematocrit up to four hours after general anesthesia. Key words: Packed cell volume, crystalloids, acepromazine, propofol, bleeding ResumoA mensuração de parâmetros séricos durante procedimentos dependentes de anestesia geral são passíveis de variações devido a diferenças do protocolo utilizado, armazenamento esplênico e também da fluidoterapia instituída. O objetivo deste trabalho foi avaliar o hematócrito buscando evidenciar as alterações flutuantes promovidas por fluidoterapia controlada e anestesia geral em cães submetidos a ovariohisterectomia laparoscópica. Seis cadelas sem raça definida foram submetidas a um protocolo anestésico com acepromazina (0,03 mg kg -1 ) e tramadol (5,0 mg kg -1 ) como medicação pré-anestésica, indução com propofol (3,0 mg kg -1 ) e mantidas com isoflurano e ventilação mecânica durante 120 minutos. Após a indução, receberam a infusão de 10,0 ml kg hr -1 de solução Ringer com lactato. Foram realizadas aferições de hematócrito do início (ou antes?) até 72 horas após a anestesia, sendo avaliadas 1 Discente, Programa de Pós-graduação em Ciências Veterinárias, Universidade Federal do Paraná, UFPR, Curitiba, PR. Brasil.

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“…49,50 Given the hemodynamic effects of anesthetic drugs, changes in shear stress within the circulation may be expected to modify platelet and PMV behaviour, but there are no published data on how this may affect PMV. Statins have no effect on PMV numbers.…”

Section: Anesthetics and Other Drugsmentioning

confidence: 99%

Platelet Microvesicles (Microparticles) in Cardiac Surgery

Tempo

Englyst

Holloway

et al. 2016

Journal of Cardiothoracic and Vascular Anesthesia

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The In Vitro Effects of Isoflurane, Sevoflurane, and Propofol on Platelet Aggregation

Cited by 43 publications

References 7 publications

La technique anesthésique n’affecte pas la performance d’un modèle de réductions cycliques de flot chez le lapin : une étude pilote

La technique anesthésique n’affecte pas la performance d’un modèle de réductions cycliques de flot chez le lapin : une étude pilote

Influence of Ringer’s lactated solution in continuous infusion and general anesthesia on hematocrit in dogs

Platelet Microvesicles (Microparticles) in Cardiac Surgery

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