The in-vitro effects of sevoflurane and desflurane on the contractility of pregnant human uterine muscle

Four cases of the ex utero intrapartum treatment (EXIT) procedure: anesthetic implications

“…This is true for the older agents halothane and enflurane as well as for the modern agents isoflurane, sevoflurane and desflurane. 21 The uterine responsiveness to oxytocin, as investigated in patients after vaginal delivery, is however maintained up to 0.8 and 0.9 MAC for halothane and enflurane respectively. 22 In this study it was also shown that "with both agents there was a rapid recovery of spontaneous uterine activity when deep planes of anesthesia was lightened."…”

The effect of type of anesthesia on intra-and postoperative blood loss at elective cesarean section

“…Turner et al [12] extracted uterine muscles after c-sec and investigated how much sevoflurane and desflurane would hinder uterine contractions. They hinder the contractions of uterine muscles at 0.5 MAC, 1 MAC and 1.5 MAC, respectively, and they were similar in extent to each other.…”

Inhibitory effect of alprostadil against sevoflurane-induced myometrial relaxation in rats

“…The effect of drugs on myometrium contraction has been studied using isolated myometrial strips from humans [9,10] and rats [11,12]. The amplitude and frequency have traditionally been used as an index of myometrium contraction because they can be easily measured from analog data.…”

“…Recently, new computer software has made it possible to calculate the AUC [13][14][15]. Previous studies have found that sevofl urane reduces both the amplitude and frequency of myometrium contractions in myometrium isolated from humans [9,10] and rats [11,12]. Sevofl urane-induced myometrial relaxation has also been established using the AUC [13][14][15].…”