The In Vivo Anti-Inflammatory Effects of Qt-2 (A Traditional Medicine Remedy) Water Extract

Abstract

This study investigated the in vivo anti-inflammatory effect of QT-2, a traditional medicinal remedy renowned for its potential in treating arthritis. We assessed its acute and chronic antiinflammatory properties at two different doses (11.8 g/kg/day and 23.6 g/kg/day) using three in vivo models. The results revealed significant anti-inflammatory effects in the first carrageenaninduced paw edema model. QT-2 extract demonstrated a discernible reduction in paw edema volume, statistically comparable to the diclofenac 15 mg/kg treated group. In the second peritonitis model, both doses of QT-2 extract exhibited pronounced anti-inflammatory potential, leading to significant reductions in transudate volume, protein concentration within the transudate, and lowered optical density, comparable to the diclofenac 15 mg/kg treated group. In the third anti-granuloma model, both QT-2 extract doses caused marked reductions in the weight of dried and fresh granulomas, equivalent to the Prednisolone 15 mg/kg treated group. These results demonstrate the anti-inflammatory capability of QT-2 for inflammatory-related conditions.