The in vivo antioxidant activity of soybean isoflavones in human subjects

Fritz, Krista L.; Seppanen, Christine M.; Kurzer, Mindy S.; Csallany, A. Saari

doi:10.1016/s0271-5317(03)00005-8

Cited by 88 publications

(49 citation statements)

References 22 publications

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“…Therefore, attention of many research groups and institutions has been focused on usage of natural antioxidants. Lately, large efforts have been made to develop effective antioxidants for the purpose of inhibition of harmful effects of free radicals, released from the damaged human tissues by several biochemical pathways, such as lipid peroxidation on cell membrane and nucleotide mutation in DNA [5]. Antioxidant properties of the plants are attributed to their chemical composition which is composed of phytochemicals such as phenolic acids, flavonoids (quercetin, etc.).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant Activity, Phytochemicals and ESR Analysis of Lavandula Stoechas

Ceylan

Usta

et al. 2015

Acta Phys. Pol. A

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The antioxidant activity of phytochemicals and of the methanolic extract of Lavandula stoechas was evaluated by β-carotene-linoleate bleaching, DPPH radical scavenging, ferric reducing/antioxidant power (FRAP). The obtained results were compared with antioxidant activities of synthetic antioxidants, such as BHT and BHA. The highest antioxidant activity of the extract was observed by DPPH radical scavenging assay, which was 84.45 ± 5.1% at 1 mg ml −1 . Rutin, rosmarinic acid, and caffeic acid were main phenolics in the extract. The total phenolic content of the methanolic extract of Lavandula stoechas was found to be 105.5 ± 2.7 mg gallic acid equivalent (GAE). Electron spin resonance (ESR) measurements were also performed on the samples. Free radicals were determined by ESR method. g value was found to be 2.0034 for the Lavandula stoechas; 2.0052 for quercetin.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant Activity, Phytochemicals and ESR Analysis of Lavandula Stoechas

Ceylan

Usta

et al. 2015

Acta Phys. Pol. A

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“…Isoflavones have antioxidant activities by protecting cells from oxidative damage and free radicals [30]. Free radicals are harmful to human health [31] because they oxidize biomolecules in the cell, leading to mutagenic changes, tissue damage, and cell death.…”

Section: Introductionmentioning

confidence: 99%

Soybean Seed Phenol, Lignin, and Isoflavones and Sugars Composition Altered by Foliar Boron Application in Soybean under Water Stress

Bellaloui¹

2012

FNS

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Previous research showed that foliar boron (B) application at flowering or seed-fill growth stages altered seed protein, oil, and fatty acids. The objective of this research was to investigate the effects of foliar B fertilizer on seed phenolics (phenol, lignin, and isoflavones) and sugars concentrations. A repeated greenhouse experiment was conducted on soybean [(Glycine max(L.) Merr.)] under watered and water-stressed conditions. Soybean plants were divided into different sets, and each set was subjected to one of the following treatments: W = plants were watered with no foliar B; WB = plants were watered and received foliar B; WS = plants were water-stressed with no foliar B; WSB = plants were waterstressed and received foliar B. Foliar B was applied at rate of 0.45 kg/ha twice at flowering and twice at seed-fill stages. The results showed that total phenol and lignin concentrations were higher in seed collected from water-stressed plants compared with those collected from watered plants whether B was applied or not. The higher total phenol and lignin concentration in seed collected of water-stressed plants may be due to B-deficiency in plant tissues. Application of B resulted in higher concentrations of total seed B and isoflavones under watered and water-stressed plants. Higher cell wall B was higher in water-stressed plants than in watered plants, having an opposite trend to total B. Application of B resulted in higher seed sucrose in watered and water-stressed plants, but raffinose and stachyose were significantly higher under water-stressed plants. The research demonstrated that foliar B fertilizer altered seed phenol, lignin, isoflavones, and sugars, suggesting that B involved in phenolics and sugar metabolism. The higher cell wall B in waterstressed plants than in watered plants supports previous research that B has mainly a structural role. The higher sucrose resulting from foliar B in watered plants is desirable as sucrose contributes to seed quality. The increase of raffinose and stachyose concentrations in seed of water-stressed plants is undesirable as raffinose, and especially stachyose may be involved in water stress/drought tolerance. The current knowledge would help soybean breeders select for higher phenolic compounds and desirable sugars for higher seed qualities under drought conditions.

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“…Assim, presume-se que a ingestão de antioxidantes capazes de neutralizar os radicais livres possa ter um papel importante na prevenção destas doenças [12,7]. Dessa forma, a identificação de fontes vegetais com alta capacidade antioxidante é de extrema importância.…”

Section: -Introduçãounclassified

Teores de isoflavonas e capacidade antioxidante da soja e produtos derivados

Barbosa¹,

Hassimotto²,

Lajolo³

et al. 2006

Ciênc. Tecnol. Aliment.

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RESUMOO objetivo deste estudo foi determinar a capacidade antioxidante, o teor e as formas de isoflavonas presentes nos produtos derivados de soja e compará-los à soja em grão. A capacidade antioxidante foi mensurada por meio do método de cooxidação do β-caroteno/ ácido linoléico e pelo seqüestro de radicais livres (DPPH•). Os resultados mostraram que o conteúdo de isoflavonas nos produtos variou de 95 a 711 mg/100 g (b.s.) e o teor de fenólicos totais de 101 a 413 mg equivalentes de catequina/100 g (b.s.), sendo que o grão de soja apresentou um conteúdo de 110 e 200 mg/100 g (b.s.), respectivamente, para isoflavonas e fenólicos totais. Em relação às formas de isoflavonas a farinha integral e sua respectiva farinha desengordurada e a farinha desengordurada de soja comercial apresentaram predominância de conjugados malonilglicosídeos e β-glicosídeos, similar aos grãos de soja. O suplemento à base de gérmen de soja e a farinha desengordurada de soja apresentaram a maior capacidade antioxidante por ambos os métodos (5 μmoles equivalentes de trolox/g e ~ 0,8 μmoles equivalentes de BHT/ g amostra b.s.). Os resultados demonstraram que o conteúdo total e tipo de isoflavonas e o teor de fenólicos dos produtos de soja dependem do processamento e que a capacidade antioxidante desses produtos varia significativamente. Palavras-chave: soja e derivados protéicos, isoflavonas, capacidade antioxidante. SUMMARYISOFLAVONE CONTENT AND PROFILE AND ANTIOXIDANT ACTIVITY OF SOY AND SOY PRODUCTS. The objective of this study was to determine the antioxidant activity and isoflavone content and type of soy seeds and soy products. The antioxidant activity was measured using β-carotene bleaching and 2.2-diphenyl-1-picryl-hydrazyl (DPPH•) free radical methods. The total isoflavone content of soy products varied from 95 to 711 mg/100 g DW (expressed as aglycones) and total phenolics content from 101 to 413 mg equivalents of catechin/100 g DW. Soybeans presented 110 and 200 mg/100 g DW of isoflavones and total phenolics, respectively. The β-glycosides and malonylglycosides were the main forms of the isoflavones found in the whole flour, defatted flour and commercial defatted flour, similar to the soy seeds. The soy germ (hypocotyl) and the defatted soy flours presented the highest antioxidant activities in both methods (5.0 μmoles equivalents of trolox/g DW and ~ 0.8 μmoles equivalents of BHT/g DW). Taking this into account, the results showed that total isoflavone and phenolic contents and isoflavone profile of soy products depend on processing conditions and that antioxidant activity varied significantly among products. Keywoards: soy, soy products, isoflavones, antioxidant activity. -INTRODUÇÃOOs alimentos de origem vegetal apresentam compostos não-nutrientes (fitoquímicos) com atividades biológicas ditas promotoras da saúde, tais como atividades antioxidante, antiinflamatória e hipocolesterolêmica. Entre estes podemos citar as catequinas do chá verde e do vinho, as antocianinas dos frutos vermelhos, os flavonóis das folhas e as isoflavona...

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The in vivo antioxidant activity of soybean isoflavones in human subjects

Cited by 88 publications

References 22 publications

Evaluation of Antioxidant Activity, Phytochemicals and ESR Analysis of Lavandula Stoechas

Evaluation of Antioxidant Activity, Phytochemicals and ESR Analysis of Lavandula Stoechas

Soybean Seed Phenol, Lignin, and Isoflavones and Sugars Composition Altered by Foliar Boron Application in Soybean under Water Stress

Teores de isoflavonas e capacidade antioxidante da soja e produtos derivados

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