The in Vivo Antitumor Activity of Certain Short Chain Fatty Acids

Townsend, G. F.; Baxter, Norma; Brown, William H.; Felauer, Ethel E.

doi:10.1139/o66-025

Cited by 4 publications

(2 citation statements)

References 1 publication

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“…The inhibition of glycolysis in tumours would result in an energy loss which might be reflected in a reduced growth rate. It is of interest, therefore, that antitumor activity has been observ ed with fatty acids [15][16][17][18], This action was observed to be influenced by the degree of saturation of the fatty acids and may be affected by the extent to which different fatty acids and related compounds are subject to (3-oxidation [18]. The inhibition of glycolytic enzymes by fatty acids suggests a possible mechanism for their action on tumors.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Glycolytic Enzymes of Rat Liver and Hepatomas by Free Fatty Acids

Lea¹,

Weber²,

Morris³

1976

Oncology

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The action of free fatty acids on glycolytic enzymes was compared in normal and neoplastic tissues. Preincubation of tissue supernatant fractions with octanoate or laurate caused an inhibition of the activities of hexokinase and phosphofructokinase. An inhibition was also observed of lactate production with either glucose or glucose 6-phosphate as substrate. A similar degree of inhibition was observed for actions on normal liver and kidney, on the 7800 and 3924-A hepatomas and on the MK-3 renal cortical tumor. The possible relationship between the inhibition of glycolytic enzymes by fatty acids and anti-tumor activity previously observed with these compounds was noted.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Glycolytic Enzymes of Rat Liver and Hepatomas by Free Fatty Acids

Lea¹,

Weber²,

Morris³

1976

Oncology

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“…Ethyl pivalate (275) has demonstrated antitumor activity against Ehrlich L-1210 leukemia (284). Compound pivaloylphenothiazine, 276, showed 24.3% inhibition of Ehrlichtype tumors in male mice (285).…”

Section: Biological Activities Of Neo Acids and Derivativesmentioning

confidence: 99%

Natural neo acids and neo alkanes: Their analogs and derivatives

Dembitsky

2006

Lipids

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This review presents more than 260 naturally occurring (as well as 47 synthesized) neo fatty (carboxylic) acids, neo alkanes, and their analogs and derivatives, isolated and identified from plants, algae, fungi, marine invertebrates, and microorganisms, that demonstrate different biological activities. These natural metabolites are good prospects for future chemical preparations as antioxidants, and also as anticancer, antimicrobial, and antibacterial agents. Described also are some synthetic bioactive compounds containing a tertiary butyl group(s) that have shown high anticancer, antifungal, and other activities. Applications of some neo fatty (carboxylic) acid derivatives in cosmetic, agronomic, and pharmaceutical industries also are considered. This is the first review to consider naturally occurring neo fatty (carboxylic) acids, neo alkanes, and other metabolites containing a tertiary butyl group(s) [or tert-butyl unit(s)].

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Effect of sodium octanoate on leucine incorporation into protein of rat liver slices and of Yoshida ascites hepatoma cells

Agostini¹

1978

Experientia

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The in Vivo Antitumor Activity of Certain Short Chain Fatty Acids

Cited by 4 publications

References 1 publication

Inhibition of Glycolytic Enzymes of Rat Liver and Hepatomas by Free Fatty Acids

Inhibition of Glycolytic Enzymes of Rat Liver and Hepatomas by Free Fatty Acids

Natural neo acids and neo alkanes: Their analogs and derivatives

Effect of sodium octanoate on leucine incorporation into protein of rat liver slices and of Yoshida ascites hepatoma cells

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