The in Vivo antiviral activity of 1-adamantanamine (amantadine)

Protection of Man from Natural Infection with Influenza A2 Hong Kong Virus by Amantadine: A Controlled Field Trial

“…It also inhibits virus growth in laboratory animals to some extent (Davies et al. 1964Cochran et al, 1965;Grunert et al, 1965;Schild and Sutton, 1965;Bryans et al, 1966;Wendel et al, 1966).…”

Efficacy of Zanamivir against Avian Influenza A Viruses That Possess Genes Encoding H5N1 Internal Proteins and Are Pathogenic in Mammals

“…For all mice, the changes in weight and the number of mice that died were recorded daily. The mean survival day (MSD), i.e., the mean number of days mice survived, was calculated by the following formula: MSD ϭ ⌺[f(d Ϫ 1)]/n, where f is the number of mice recorded on day d (the number of survivors on day 16 was included in f for that day) and n is the number of mice in a group (8).…”

Influenza Infections of Mice. I. Curative Activity of Amantadine HCI

“…However, Davies et al (1) and Grunert et al (2) reported that treatment with amantadine HCl as late as 72 hr, but not 96 hr, after infection time reduced mortality and increased survival time of mice infected with influenza A2/AA/2/60. However, Davies et al (1) and Grunert et al (2) reported that treatment with amantadine HCl as late as 72 hr, but not 96 hr, after infection time reduced mortality and increased survival time of mice infected with influenza A2/AA/2/60.…”

“…Glucokinase, a hexokinase type enzyme with a high K , toward glucose, has been established as an important factor in glucose phosphorylation by rat liver (1)(2)(3)(4). It was a t first reported that glucokinase did not occur in human liver ( 5 ) ; subsequently, it was detected there by starch gel electrophoresis (6).…”