The In vivo Biochemical and Oxidative Changes by Ethanol and Opium Consumption in Syrian Hamsters

Mohammadi, Abbas; Mirzaei, Fateme; Jamshidi, Mohammad; Yari, Reza; Pak, Solmaz; Sorkhani, Arash Noori; Norouzian, Parham; Abdolkarimi, Vahideh; Oshaghi, Ebrahim Abbasi

doi:10.5539/ijb.v5n4p14

Cited by 22 publications

(18 citation statements)

References 16 publications

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“…The high levels of MDA are known as a positive indicator for lipid peroxidation. Mohammadi et al (19) reported that MDA level significantly increased in opium-treated animals compared to controls (56.52% vs. 30.12 %). The results of the study on Syrian golden hamsters revealed that opium had the capability to stimulate oxidative stress.…”

Section: Malondialdehyde (Mda)mentioning

confidence: 99%

“…In addition, opium raises total cholesterol, Low density lipoprotein-cholesterol (LDL-C), triglyceride (TG) and very low density lipoproteincholesterol (VLDL-C) and reduces high density lipoproteincholesterol (HDL-C), which can act as an atherogenic indicator. It is supposed that reduction of antioxidant activity is in relation to increase of LDL oxidation (19). It was reported that drug abuse is an independent predictive risk factor for improvement of vein thrombosis (14).…”

Section: Malondialdehyde (Mda)mentioning

confidence: 99%

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Study of Oxidants and Antioxidants in Addicts

Karajibani

Montazerifar

Feizabad

2016

Int J High Risk Behav Addict

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Context: This study was a systematic review that aimed to extract published articles regarding oxidant and antioxidants status in opium addiction by searching in PubMed, Google Scholar engine, SID, and Magiran databases. Evidence Acquisition: Sixty-six published articles were investigated in this review, which were selected from studies among the Iranian society and other societies from 1976 to 2015. All articles published in different fields of descriptive-analytical, experimental, and interventional studies were considered. Results: Several studies have shown that with increased production of free radicals and reactive oxygen species (ROS), the enzymatic and non-enzymatic antioxidants such as glutathione (GSH) and glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase activities, and also the concentration of vitamins A, E, C and total antioxidant capacity (TAC) decrease in opium addiction. Increased atherogenic indexes such as Low density lipoprotein/high density lipoprotein (LDL/HDL) ratio and malondialdehyde (MDA) may contribute to the increased risk of cardiovascular disease. However, it has also increased other markers of oxidative stress including: isoprostanes, 8-oxoguanine and protein carbonyl. Conclusions: Oxidative stress increases in opium-addicted people. It seems that opium is capable of provoking oxidative stress and also, has harmful effects on lipid profile and antioxidant enzyme. Drug addicts were found to have antioxidant vitamin deficiency.

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Section: Malondialdehyde (Mda)mentioning

confidence: 99%

Section: Malondialdehyde (Mda)mentioning

confidence: 99%

Study of Oxidants and Antioxidants in Addicts

Karajibani

Montazerifar

Feizabad

2016

Int J High Risk Behav Addict

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“…Particular attention should be paid to patients with cardiovascular diseases and cardiac risk factors, such as obesity, hypertension, and high cholesterol, as they may be more sensitive to physiological stress, such as increased strain on the heart and the increased cardiac workload induced by alcohol hangovers [1,32,33]. Also, ethanol may provoke oxidative stress [34]. Additionally, it is shown in a systematic review and meta-analysis by Brien et al that moderate intake of alcohol have favourable effects on levels of high density lipoprotein cholesterol, apolipoprotein A1, adiponectin, and fibrinogen which indicates a protective effect of alcohol consumption, particularly associated with a lower risk of coronary heart disease [35].…”

Section: Implications For Future Researchmentioning

confidence: 99%

Alcohol Hangover and Risk of Drinking Problems and Alcohol Use Disorder: A Systematic Review

Mølbak¹,

Schou²,

Tolstrup³

2017

J Alcohol Drug Depend

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Introduction: Despite its high frequency, hangovers have received little systematic attention in the field of alcohol research, even though alcohol hangover contributes to a large number of socioeconomic consequences as well as health risks. Alcohol-induced hangover is a complex syndrome defined by a spectrum of symptoms. Not all drinkers experience hangovers, indicating individual alcohol tolerance. It is unknown whether frequently experiencing hangovers predicts the risk of problem drinking and alcohol use disorder.

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“…Low-density lipoprotein-cholesterol was calculated according to the Friedewaldequation (20)(21)(22).…”

Section: Biochemical Factorsmentioning

confidence: 99%

Combination of Ezetimibe and Garlic Reduces Serum Lipids and Intestinal Niemann-Pick C1-like 1 Expression More Effectively in Hypercholesterolemic Mice

Mohammadi¹,

Vafaei²,

Moradi³

et al. 2015

Avicenna J Med Biochem

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Background: Combination therapy plays an important role in the management of cardiovascular disease (CVD).Objectives: The aim of this experiment was to study the influence of garlic combined with ezetimibe on lipid profile as well as intestinal Niemann-Pick C1-like 1 (NPC1L1) expression in normal and hypercholesterolemic mice. Materials and Methods: A total of 40 mice were randomly divided into five groups: Group 1: hypercholesterolemic group (received 2% w/w cholesterol + 0.5% w/w cholic acid in their diet), Group 2: garlic group (hypercholesterolemic diet + 4% w/w garlic extract), Group 3: ezetimibe group (hypercholesterolemic diet + 0.005% w/w ezetimibe), Group 4: combination group (hypercholesterolemic diet + 0.005% w/w ezetimibe + 4% w/w garlic) and Group 5: control (chow only). Results: Serum low-density lipoprotein-cholesterol (LDL-C) and total cholesterol (TC) levels were significantly decreased in ezetimibe, garlic (both P < 0.05), and combination groups (P < 0.001). Also, triglycerides and very low-density lipoprotein-cholesterol (VLDL-C) were significantly lower in garlic and combination groups (P < 0.05). Liver enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were also significantly decreased in garlic, ezetimibe (both P < 0.05) and combination groups (P < 0.001) in comparison with hypercholesterolemic animals. Analysis of semi quantitative RT-PCR results showed that the levels of NPC1L1 was also significantly less (P < 0.01) in the garlic, ezetimibe, and combination groups (P < 0.001) compared with the controls. Based on the results, the combination of garlic and ezetimibe can lower serum lipids and liver enzymes more effectively in hypercholesterolemic mice. Conclusions: This experiment revealed that a possible mechanism for the beneficial effects of garlic and ezetimibe combination in lowering plasma LDL-C and TC is inhibition of intestinal cholesterol absorption. More research might be necessary to determine the efficacy and the exact mechanism of this co-administration.

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The In vivo Biochemical and Oxidative Changes by Ethanol and Opium Consumption in Syrian Hamsters

Cited by 22 publications

References 16 publications

Study of Oxidants and Antioxidants in Addicts

Study of Oxidants and Antioxidants in Addicts

Alcohol Hangover and Risk of Drinking Problems and Alcohol Use Disorder: A Systematic Review

Combination of Ezetimibe and Garlic Reduces Serum Lipids and Intestinal Niemann-Pick C1-like 1 Expression More Effectively in Hypercholesterolemic Mice

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