The in vivo effect of L-arginine on skin elasticity in mice

Souza, Ádria do Prado Barros de; Oliveira, Marina Miranda Rocha de; Andrade, Rafael Rocha de; Amorim, Rivadávio Fernandes Batista de; Bocca, Anamélia Lorenzetti; Borin, Maria de Fátima

doi:10.1590/s2175-97902017000300045

Cited by 7 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, in the study of injured skin of mice, the expression of iNOS and eNOS was determined both in and around the skin lesion and subsequently in granulation tissues, which may serve as a marker of inflammatory activity and duration of the lesion [9]. At the same time, it was noted that with the skin aging, age-related changes were accompanied by a decrease in L-arginine, a substrate for NO synthesis, and a decrease in iNOS expression, which reduced the bioavailability of L-arginine [10].…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical characteristics of inducible nitric oxide synthase and estrogen receptors alpha expression in patients with keratoderma climactericum

Makurina

Тертышный

Syusyuka

et al. 2022

ZMJ

View full text Add to dashboard Cite

Aim. To examine the characteristics of immunohistochemical expression of inducible nitric oxide synthase and estrogen receptors alpha in patients with keratoderma climactericum compared to postmenopausal women with clinically intact skin, to reveal possible correlation between these markers’ expression levels and pathomorphogenesis of menopausal keratoderma. Materials and methods. The pathomorphological and immunohistochemical analysis was performed on the biopsy material of 22 patients with keratoderma climactericum, who constituted the study group, and on the autopsy material from 32 women in a postmenopausal period without any signs of climacteric keratoderma, who were considered as a control group. Results. A significant difference was found in the area and intensity of inducible nitric oxide synthase expression between the study group diagnosed with keratoderma climactericum and the control group with unaffected skin, with increasing expression parameters among patients with keratoderma. A significant difference was also observed in the area and intensity of estrogen receptors alpha expression between the study and the control group, this time with increasing expression parameters among the control group. Conclusions. Patients with keratoderma climactericum demonstrate statistically significantly higher levels of nuclear and cytoplasmatic expression of inducible nitric oxide synthase in epidermal and dermal cells than individuals from the control group, which may indicate acute inflammation as a part of climacteric keratoderma pathogenesis. The area and intensity of estrogen receptors alpha expression in material from patients diagnosed with menopausal keratoderma are lower than in the material from the control group, which demonstrates a correlation between estrogen-deficient state in postmenopausal period and the development of skin changes in women with keratoderma climactericum.

show abstract

Section: Discussionmentioning

confidence: 99%

Immunohistochemical characteristics of inducible nitric oxide synthase and estrogen receptors alpha expression in patients with keratoderma climactericum

Makurina

Тертышный

Syusyuka

et al. 2022

ZMJ

View full text Add to dashboard Cite

show abstract

“…Compared to the control group (100%), Young's modulus decreased by 32.8% in the diabetic group, by 44.7% in the diabetic group treated with L-arginine, and by 72.9% after treatment with L-arginine. This is to be expected, as L-arginine is used for skin renewal through the NO mechanism [31,52,53]. The reduced stiffness of the diabetic dermis is probably due to the degradation and fragmentation of collagen fibrils [10].…”

Section: Afm Analysismentioning

confidence: 91%

Short-Term l-arginine Treatment Mitigates Early Damage of Dermal Collagen Induced by Diabetes

Miler,

Rabasovic,

Askrabic

et al. 2024

Bioengineering

View full text Add to dashboard Cite

Changes in the structural properties of the skin due to collagen alterations are an important factor in diabetic skin complications. Using a combination of photonic methods as an optic diagnostic tool, we investigated the structural alteration in rat dermal collagen I in diabetes, and after short-term l-arginine treatment. The multiplex approach shows that in the early phase of diabetes, collagen fibers are partially damaged, resulting in the heterogeneity of fibers, e.g., “patchy patterns” of highly ordered/disordered fibers, while l-arginine treatment counteracts to some extent the conformational changes in collagen-induced by diabetes and mitigates the damage. Raman spectroscopy shows intense collagen conformational changes via amides I and II in diabetes, suggesting that diabetes-induced structural changes in collagen originate predominantly from individual collagen molecules rather than supramolecular structures. There is a clear increase in the amounts of newly synthesized proline and hydroxyproline after treatment with l-arginine, reflecting the changed collagen content. This suggests that it might be useful for treating and stopping collagen damage early on in diabetic skin. Our results demonstrate that l-arginine attenuates the early collagen I alteration caused by diabetes and that it could be used to treat and prevent collagen damage in diabetic skin at a very early stage.

show abstract

“…On the other hand, L-Arg is an amino acid that has been incorporated into different materials for wound healing (19,20). The beneficial effects of this amino acid for the skin have been tested in combination with tryptophan as antimicrobial peptides, showing bactericide effects on methicillin-resistant S. aureus isolated from the skin (21) and increasing the elasticity of the treated skin (22). A fish model for wound healing has shown that a diet with L-Arg improves wound closure, decreases the expression of the pro-inflammatory tumor necrosis factor (TNF-α), and increases the expression of the transforming growth factor β1 (TGF-β1), which is related to tissue regeneration (23), these characteristics are desirables for a medicine to treat the lesions in psoriasis and AD.…”

Section: Introductionmentioning

confidence: 99%

psoInhibition of proliferation, migration, and adhesion of skin fibroblasts by enzymatic poly(gallic acid) grafted with L-Arginine

Ortega-Sánchez¹,

Pérez-Díaz²,

Martínez-López³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

The in vivo effect of L-arginine on skin elasticity in mice

Cited by 7 publications

References 36 publications

Immunohistochemical characteristics of inducible nitric oxide synthase and estrogen receptors alpha expression in patients with keratoderma climactericum

Immunohistochemical characteristics of inducible nitric oxide synthase and estrogen receptors alpha expression in patients with keratoderma climactericum

Short-Term l-arginine Treatment Mitigates Early Damage of Dermal Collagen Induced by Diabetes

psoInhibition of proliferation, migration, and adhesion of skin fibroblasts by enzymatic poly(gallic acid) grafted with L-Arginine

Contact Info

Product

Resources

About