The in vivo fate of polymeric micelles

Cai, Yifan; Qi, Jianping; Lü, Yi; He, Haisheng; Wu, Wei

doi:10.1016/j.addr.2022.114463

Cited by 90 publications

(54 citation statements)

References 397 publications

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“…The critical micelle concentration (CMC), which reflects the physical stability to maintain the micelle structure, was determined by a fluorescence method. The CMCs of Pep-SSetc-CPT and Pep-SSetc-CPT@Phen micelles were 0.62 and 0.49 mg/L, respectively (Figure a,b), which are only about 1/10 of values for most nanodrugs, indicating that both micelles are very stable against dilution. Moreover, both Pep-SSetc-CPT and Pep-SSetc-CPT@Phen in the 50% FBS solution were also highly resistant to nonspecific protein adsorption since the deviation of both sizes and PDI is minor after incubation (Figure c,d).…”

Section: Resultsmentioning

confidence: 98%

Enhancing the Antitumor Efficacy of Zwitterionic Peptide-Based Nanoscale Micelles through Sensitizing Their Response in Solid Tumors

Wei

Xiang

Xue

et al. 2022

ACS Appl. Nano Mater.

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Although nanodelivery has made unprecedented progress in enhancing the efficacy of chemotherapeutic drugs, there is still much room for improvement. Zwitterionic nanodrugs have great potential to be a universal platform for nanodelivery because of the exceptional hemocompatibility and ultralow immunogenicity, although they are sensitive to the tumor microenvironment (TME) for tumor cell targeting and internalization. Here, a negatively biased zwitterionic peptide micelle, a mimic of albumin, was developed to improve two vital factors, which are the responsive transition of stability and affinity to tumor cells from circulation to the slightly acidic TME. The incorporation of positively charged hydrophobic phenformin into the camptothecin (CPT)-conjugated micelles (Pep-SSetc-CPT@Phen) can make the micelles more compact to reduce premature drug release in circulation while improving the sensitivity of the micelles to MCF-7-xenografted tumors by tuning their zeta potential in the TME. Thus, Pep-SSetc-CPT@Phen exhibited more tumor-preferred biodistribution and longer blood circulation than nonphenformin-incorporated micelles (Pep-SSetc-CPT), thereby enhancing tumor growth inhibition with lower side effects. Together, these results have provided a promising combinational method to enhance the transition of stability and the sensitivity to the TME for developing biomimetic zwitterionic nanodrugs with high antitumor efficacy.

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Section: Resultsmentioning

confidence: 98%

Enhancing the Antitumor Efficacy of Zwitterionic Peptide-Based Nanoscale Micelles through Sensitizing Their Response in Solid Tumors

Wei

Xiang

Xue

et al. 2022

ACS Appl. Nano Mater.

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“…The zeta potential of nanoparticles has a major impact on their biological effects in vitro and in vivo . 38–41 We examined the zeta potential of NEs and found no difference among these nanoparticles; therefore we ruled out the effects of potentials on the biodistribution of NEs (Fig. 2e).…”

Section: Resultsmentioning

confidence: 99%

“…The zeta potential of nanoparticles has a major impact on their biological effects in vitro and in vivo. [38][39][40][41] We examined the zeta potential of NEs and found no difference among these…”

Section: Preparation and Characterization Of Nesmentioning

confidence: 99%

Nano-integrated cascade antioxidases opsonized by albumin bypass the blood–brain barrier for treatment of ischemia-reperfusion injury

et al. 2022

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“…Thus, there is an urgent need for a reliable bioimaging tool for holistic identification and accurate detection of NC to facilitate the clinical translation of NC-loaded DMNs. Second, current studies [ 26 , 28 , 41 ] on the in vivo fate of NC have focused more on the delivery system itself, ignoring the influence of the complex biological environment. The skin is the largest organ of the body, and the sites of DMNs application may affect the in vivo fate of NC-loaded DMNs, mainly because at different skin sites: (1) Different thicknesses of the epidermis and dermis meant that the area where the needle tips enter the dermis after insertion of DMNs was different; (2) Different classes of cells and matrices in the dermal region implied different interactions with NC; (3) Different mechanical strength meant different shear forces on the DMNs [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Demonstrating Biological Fate of Nanoparticle-Loaded Dissolving Microneedles with Aggregation-Caused Quenching Probes: Influence of Application Sites

Fù

Shi

et al. 2023

Pharmaceutics

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Integrating dissolving microneedles (DMNs) and nanocarriers (NC) holds great potential in transdermal drug delivery because it can simultaneously overcome the stratum corneum barrier and achieve efficient and controlled drug delivery. However, different skin sites with different thicknesses and compositions can affect the transdermal diffusion of NC-loaded DMNs. There are few reports on the biological fate (especially transdermal diffusion) of NC-loaded DMNs, and inaccurate bioimaging information of intact NC limits the accurate understanding of the in vivo fate of NC-loaded DMNs. The aggregation-caused quenching (ACQ) probes P4 emitted intense fluorescence signals in intact NC while quenched after the degradation of NC, had been demonstrated the feasibility of label intact NC. In this study, P4 was loaded in solid lipid nanoparticles (SLNs), and further encapsulated into DMNs, to track the transdermal diffusion of SLNs delivered at different skin sites. The results showed that SLNs had excellent stability after being loaded into DMNs with no significant changes in morphology and fluorescence properties. The in vivo live and ex vivo imaging showed that the transdermal diffusion rate of NC-loaded DMNs was positively correlated with skin thickness, with the order ear > abdomen > back. In conclusion, this study confirmed the site-dependency of transdermal diffusion in NC-loaded DMNs.

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The in vivo fate of polymeric micelles

Cited by 90 publications

References 397 publications

Enhancing the Antitumor Efficacy of Zwitterionic Peptide-Based Nanoscale Micelles through Sensitizing Their Response in Solid Tumors

Enhancing the Antitumor Efficacy of Zwitterionic Peptide-Based Nanoscale Micelles through Sensitizing Their Response in Solid Tumors

Nano-integrated cascade antioxidases opsonized by albumin bypass the blood–brain barrier for treatment of ischemia-reperfusion injury

Demonstrating Biological Fate of Nanoparticle-Loaded Dissolving Microneedles with Aggregation-Caused Quenching Probes: Influence of Application Sites

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