The In Vivo, In Vitro and In Ovo Evaluation of Quantum Dots in Wound Healing: A Review

Abstract

Wound is defined as primarily damaged or disruption of skin contributed to the loss of its microstructure stability and which undergoes complex wound healing process. However, there are tons of factors that could affect the wound healing process such as infection and slow angiogenesis. Involvement of nanotechnologies therapies in wound care research aims to facilitates this healing process. Quantum dots (QDs) are an advanced nanomaterial technology found to be useful in clinical and biomedical applications. This review has been carried out to provide a summary of the application of QDs in acute or chronic wound healing. A thorough searching was done via Web of Science and SCOPUS database to obtain relevant articles including the in vivo, in vitro and in ovo studies. The results demonstrated a similar effect of different types of QDs, or an improvement of QDs in wound healing, antibacterial and angiogenesis properties. This review demonstrated the effectiveness of QDs for the wound healing process mainly by their antibacterial activity. Uniquely, the antibacterial effect unraveled an increasing trend over time influenced by the various concentration of QDs. In conclusion, the application of QDs support the wound healing phases and proven to be effective in vivo, in vitro and in ovo. However, the future QDs work should focus on the molecular level for the details of cellular interactions and pathways.

Cellular Interaction of Human Skin Cells towards Natural Bioink via 3D-Bioprinting Technologies for Chronic Wound: A Comprehensive Review

“…The epidermis layer is abundant with keratinocytes to protect the skin from external infections, whereas the dermis layer acts as the skin’s appendages [ 25 ]. The dermis is made up of fewer cellular constituents, primarily fibroblasts [ 26 ].…”

Microneedle-Mediated Transdermal Delivery of Drug-Carrying Nanoparticles

“…Quantum dots are semiconductor nanomaterials with diameters between 2 and 100 nm, usually prepared from III-V or group II-VI elements. Quantum dot excitation light has wide band range, narrow emission spectrum width, high fluorescence intensity, good stability, long life and certain antibacterial activity (Ren et al, 2020), which makes it have a good application prospect in wound healing (Salleh and Fauzi, 2021), drug transport (Fakhri et al, 2017), fluorescent biosensors (Hu et al, 2021) and disease diagnosis (Mansuriya and Altintas, 2021). In recent years, metallic nanoparticles have attracted growing interest in drug delivery, and the modification and functionalization of metallic nanoparticles with specific functional groups allow them to bind to antibodies, drugs and other ligands, making metallic nanoparticles promising in biomedical applications (Patra et al, 2018).…”

Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications

“…The different mechanisms through which carbon quantum dots exert antibacterial activities all act across both Gram-positive and Gram-negative bacterial strains. However, antibacterial efficacies of carbon quantum dots have been suggested to be slightly stronger for Gram-positive than for Gram-negative bacterial strains due to the possession of an inner and outer lipid membrane by Gram-negative bacteria consisting of lipids, proteins and lipopolysaccharides that make intracellular entry of carbon quantum dots more difficult [ 100 ]. This suggestion is confirmed by the generally higher MIC values of different quantum carbon dots against Gram-negative strains in Table 2 .…”