The in vivo performance of a sol–gel glass and a glass-ceramic in the treatment of limited bone defects

In vivo osteointegration of three-dimensional crosslinked gelatin-coated hydroxyapatite foams

“…This suggests that it performed as an adequate scaffold according to Shors criteria [21] for bone growth over a bioactive implant under ideal conditions (stability, viability and proximity), by means of a process of mesenchymal cell recruitment from the surrounding tissues and subsequent transformation into bone-forming cells. This observation has been reported by the authors in previous experimental studies in rabbits with sol-gel glass and glass ceramic implants in the treatment of limited [22] and critical bone defects [23]. Moreover, the observed well-delimited foreign body reaction, with multinucleated giant cells containing the material inside the cytoplasm, may be explained by incomplete resorption of the HABP ceramic scaffold during the four months of the in vivo study, suggesting that it may disappear after a longer follow-up than that used in our research.…”

Effects of strontium-doped bioactive glass on the differentiation of cultured osteogenic cells

“…Although bioactive glasses have been used for over 15 years with success in oral and maxillo-facial clinical applications (Froum et al, 1998;Peltola et al, 2006), limited benefits have been reported (Turunen et al, 2004;Wang et al, 2005). Recently, due to the growing evidence showing that strontium influences bone cells and bone metabolism in vitro and in vivo (Marie, 2006), melt-derived strontiumdoped bioactive glasses prepared from a base 45S5 bioglass have been developed and implanted in rat tibia bone marrow (Gorustovich et al, 2010). However, the affinity indices of the strontium-doped bioactive glass, i.e., the percentage of bone at the material-tissue interface, did not differ significantly with respect to 45S5.…”

“…However, the affinity indices of the strontium-doped bioactive glass, i.e., the percentage of bone at the material-tissue interface, did not differ significantly with respect to 45S5. New bioactive glasses have been developed using the sol-gel process to improve the biological properties of these biomaterials (Li et al, 1991;Pereira et al, 1994;Hamadouche et al, 2001;Olmo et al, 2003;Gil-Albarova et al, 2004;Yan et al, 2006). The objective of this study was to evaluate the effect of new strontium-doped bioactive glasses manufactured by means of a sol-gel method on biological events associated with osteoblast differentiation.…”

Dental Implant Surface Enhancement and Osseointegration

“…Sol-gel titania films may be prepared using a dip coating or spin coating process (Gan et al, 2004). In vivo bone tissue evaluations of surfaces modified using the sol-gel method have shown better osseointegration with no adverse reaction (Gan et al, 2004, Gil-Albarova et al, 2004. However, the behavior of sol-gel modifications of loaded osseointegrated implants in the long term remains unknown.…”