The Inactivation of Chinese Hamster Cells by X Rays: The Effects of Chemical Modifiers on Single- and Double-Events

Chapman, J. D.; Gillespie, C.J.; Reuvers, A. P.; Dugle, D.L.

doi:10.2307/3574272

Cited by 89 publications

(22 citation statements)

References 27 publications

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“…To account for hypoxia, oxygen enhancement ratio (OER) factors of 1.75 and 3.25 were used for a and b-inactivation, respectively. 68,69 An a/b ratio of 8.5 Gy was derived for well-oxygenated cells and of 15.5 Gy for hypoxic cells. Orton 70 commented on Nahum et al 42 results claiming that these authors used an incorrect value of b for hypoxic cells.…”

Section: The Influence Of Hypoxiamentioning

confidence: 99%

What do we know about the α/β for prostate cancer?

2012

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Since last decade, the debate on the parameter which reflects prostate cancer sensitivity to fractionation in a radiotherapy treatment, the α/β, has become extensive. Unlike most tumors, the low labeling indices (LI) and large potential doubling time that characterize the prostate tumor led some authors to consider that it may behave as a late responding tissue. So far, the existing studies with regard to this subject point to a low value of α/β, around 2.7 Gy, which may be considered as a therapeutic gain in relation to surrounding normal tissues by using fewer and larger fractions. The aim of this paper is to review several estimates that have been made in the last few years regarding the prostate cancer α/β both from clinical and experimental data, as well as the set of factors that have potentially influenced these evaluations.

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Section: The Influence Of Hypoxiamentioning

confidence: 99%

What do we know about the α/β for prostate cancer?

2012

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“…damage is considered to be the triggering event in the onset of IRR, then the small difference in the onset of IRR between oxic and hypoxic conditions is surprising since OH * has a minor role in cell killing in hypoxic environments compared with that in air [65,66]. However, it may be important when considering OH * to note that hydroxyl radicals are not expected to cause damage uniformly throughout the DNA molecule [67], so accessibility to DNA may be an important factor.…”

Section: Skov and Marples: Survival At Low Radhtim Doses Oxygenmentioning

confidence: 99%

Increased radioresistance at clinical doses: Investigations from the survival perspective

Skov¹,

Marples²

1994

Radation Oncology Invest

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SUMMARY Standard models of radiation action do not accurately describe survival at low clinically relevant X-ray doses. This was made evident by survival experiments using methods which assayed a precise number of cells. At extremely low doses of X-rays (< ~0 . 5 Gy) a hypersensitive response exists which results in an inflection in the survival curve describing the response of many cell lines. In the case of sparsely ionizing radiations, this sensitive response is typically followed by an increased resistant response with a further increment in dose, which varies with cell line. This phenomenon may be explained as resistance induced by small doses of radiation. The background of this clinically interesting effect is described, as are methods to measure survival up to doses of -4 Gy. Evidence for increased radioresistance is reviewed and then briefly compared with the adaptive response which has been well studied in lymphocytes at still lower doses using endpoints other than survival. Possible implications for clinical treatment are considered. In addition, we summarize our recent studies directed toward understanding the molecular basis of the increased radioresistance using modifiers of radiation response, repair-deficient cell lines, and radiation of different linear energy transfer (LET). While DNA damage appears to be a possible trigger for the response, the natures of the exact lesion(s) and the molecular response(s) which result remain unknown. Radiat Oncol Invest 1995;2:201-21 I . 0 1995 Wdey-Liss, Inc.

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“…K m is the PO2 where half-maximum sensitisation is obtained, K m is fixed. The parameters describing the dose modifying effects of oxygen have previously been reported (Chapman et al 1975;Palcic and Skarsgard 1984;Wouters and Brown 1997;Nahum et al 2003;Malinen et al 2006), a typical value for the OER is 1.75.…”

Section: Ii1 Tumour Control Probabilitymentioning

confidence: 99%

“…The OER as a function of the PO2 is found by fitting experimental enhancement ratios (Chapman et al 1975;Palcic and Skarsgard 1984) to the phenomenological relation.…”

Section: Ii1 Tumour Control Probabilitymentioning

confidence: 99%

Radiobiological Modelling in Radiation Oncology

Warkentin¹

2007

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The Inactivation of Chinese Hamster Cells by X Rays: The Effects of Chemical Modifiers on Single- and Double-Events

Cited by 89 publications

References 27 publications

What do we know about the α/β for prostate cancer?

What do we know about the α/β for prostate cancer?

Increased radioresistance at clinical doses: Investigations from the survival perspective

Radiobiological Modelling in Radiation Oncology

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