The COVID-19 pandemic has forced many employees to work from home (WFH) and more heavily rely on technology to conduct work, calling for further empirical investigation into the effects of work-related technology and the WFH environment on employee wellbeing. This study investigates the relationship between work-related email (WRE) use during nonwork hours and emotional exhaustion in a sample of U.S. employees required to WFH during the pandemic, with results suggesting that psychological detachment and work-family conflict (WFC) play important roles in this relationship. Furthermore, telepressure (i.e., the preoccupation/urge to promptly respond to WRE) moderated the relationship between WRE use and psychological detachment, which offers insight into the psychological processes behind WRE use after hours. Direct and indirect effects between WRE use and emotional exhaustion were also compared to effects generated using data from an independent sample of pre-pandemic in-office employees to determine whether the pandemic context has amplified the observed relationships. Results show that all direct/indirect effects, except for the effect of WRE use after hours on psychological detachment, were stronger in those required to WFH. These findings shed light onto the similarities and differences between the current and pre-pandemic work landscapes and have important implications for lawmakers, organizational leaders, and employees.