The incidence and clinical characteristics of the immune phase eye disease in treated cases of human leptospirosis

Pappachan, Joseph M; Mathew, Sheela; Thomas, Baby; Renjini, K; Scaria, Charles K; Shukla, Jyoti

doi:10.4103/0019-5359.32929

Cited by 17 publications

(13 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, immunological disease such as uveitis occurs (Rathinam et al 2005). However, Pappachan et al 2007 found that patients only developed mild uveitis if they were treated with antibiotics during the acute phase of illness. This explains why in the second case the patient developed mild anterior uveitis as she was treated with systemic antibiotics earlier on.…”

Section: Discussionmentioning

confidence: 99%

Conjunctiva Granuloma, a Rare Presentation of Ocular Leptospirosis Presenting as Conjunctiva Granuloma: Case Series

Yin¹

2018

View full text Add to dashboard Cite

ABSTRAKDiagnosis okular leptospirosis adalah mencabar dan memerlukan penelitian sejarah terhadap infeksi leptospira terdahulu di samping sokongan kajian makmal yang baik. Siri kes ini melaporkan dua orang wanita muda dengan keradangan granuloma lapisan konjuntiva, dan dalam pengetahuan kami, merupakan dua kes pertama yang dilaporkan tentang leptospirosis okular dengan granuloma konjuntiva. Diagnosa definitif leptospira okular dibuat berdasarkan keputusan ujian makmal, di mana biopsi konjuntiva bagi kedua-dua pesakit tersebut menunjukkan positif DNA leptospira. Mengimbas kembali, kedua-dua pesakit mempunyai pendedahan terhadap organisma leptospira. Kesimpulannya, diagnosa leptospira okular memerlukan penelitian klinikal yang tinggi dan perlu disokong oleh ujian makmal.Kata kunci: infeksi okular, leptospirosis, manifestasi mata ABSTRACT Diagnosis of ocular leptospirosis is challenging and requires a high index of suspicion of previous leptospiral infection and good laboratory support. This case series focuses on two young females with unilateral conjunctiva granuloma. To the best of our knowledge, these are the first two cases of ocular leptospirosis with conjunctiva granuloma. The definitive diagnosis of ocular leptospirosis was based on laboratory studies in which conjunctival biopsies in these two cases showed positive leptospira DNA. Retrospectively, the history was suggestive as both

show abstract

Section: Discussionmentioning

confidence: 99%

Conjunctiva Granuloma, a Rare Presentation of Ocular Leptospirosis Presenting as Conjunctiva Granuloma: Case Series

Yin¹

2018

View full text Add to dashboard Cite

show abstract

“…In equines, L. interrogans is responsible for causing uveitis, a major cause of blindness in these animals (Verma et al, 2005). A considerable fraction (18.4%) of infected patients from South India developed uveitis after acute leptospirosis (Pappachan et al, 2007). These considerations suggest that the role of FH polymorphism in patients with leptospiral uveitis deserves further investigations.…”

Section: Discussionmentioning

confidence: 99%

“…Pathogenic Leptospira enter the body, reach the bloodstream and can potentially invade potentially all tissues and organs (Faine et al, 1999). Clinical manifestations are quite variable and can range from an asymptomatic, subclinical infection to a fatal hepatorenal syndrome (Weil’s disease), severe pulmonary form, including pulmonary hemorrhage and acute respiratory distress syndrome, fever and jaundice (Faine et al, 1999; Levett, 2001; Bharti et al, 2003), and uveitis (Pappachan et al, 2007). …”

Section: Introductionmentioning

confidence: 99%

Interaction of human complement factor H variants Tyr402 and His402 with Leptospira spp.

et al. 2011

View full text Add to dashboard Cite

Leptospirosis is a zoonosis caused by pathogenic bacteria from the genus Leptospira. The disease represents a serious public health problem in underdeveloped tropical countries. Leptospires infect hosts through small abrasions in the skin or mucous membranes and they rapidly disseminate to target organs. The capacity of some pathogenic leptospiral strains to acquire the negative complement regulators factor H (FH) and C4b binding protein correlates with their ability to survive in human serum. In this study we assessed the functional consequences of the age macular degeneration-associated polymorphism FH His402 or FH Tyr402 on FH–Leptospira interactions. In binding assays using sub-saturating amounts of FH, the FH Tyr402 variant interacted with all the strains tested more strongly than the FH His402 variant. At higher concentrations, differences tended to disappear. We then compared cofactor activities displayed by FH His402 and FH Tyr402 bound to the surface of L. interrogans. Both variants exhibit similar activity as cofactors for Factor I-mediated cleavage of C3b, thus indicating that they do not differ in their capacity to regulate the complement cascade.

show abstract

“…The most severe presentation that may develop after the initial leptospiremic phase is Weil's disease, which is associated with impaired liver and kidney function. Mortality rates in these patients range from 5 to 40 % ( [ 192 ] (EBM:2+)).…”

Section: Clinical Symptoms and Signsmentioning

confidence: 99%

Posterior Uveitis

Neri¹,

Arapi²,

Pleyer³

et al. 2014

Immune Modulation and Anti-Inflammatory Therapy in Ocular Disorders

View full text Add to dashboard Cite

The incidence and clinical characteristics of the immune phase eye disease in treated cases of human leptospirosis

Cited by 17 publications

References 13 publications

Conjunctiva Granuloma, a Rare Presentation of Ocular Leptospirosis Presenting as Conjunctiva Granuloma: Case Series

Conjunctiva Granuloma, a Rare Presentation of Ocular Leptospirosis Presenting as Conjunctiva Granuloma: Case Series

Interaction of human complement factor H variants Tyr402 and His402 with Leptospira spp.

Posterior Uveitis

Contact Info

Product

Resources

About