The incidence and effect of bacteriospermia and elevated seminal leukocytes on semen parameters

Domes, Trustin; Lo, Kirk; Grober, Ethan; Mullen, J. Brendan; Mazzulli, Tony; Jarvi, Keith

doi:10.1016/j.fertnstert.2012.01.124

Cited by 126 publications

(142 citation statements)

References 47 publications

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…Bacteriospermia was eliminated by dental treatment, and post-treatment sperm parameters were better than those in a control group. In contrast, another study found no association between presence of bacteria in semen and sperm parameters (36). Hence, bacteriospermia was not investigated in our research.…”

Section: Discussioncontrasting

confidence: 75%

Association between periodontal status and idiopathic male infertility

et al. 2016

View full text Add to dashboard Cite

About 30% of male infertility cases are idiopathic. Previous studies reported a positive correlation between deep periodontal pockets and sperm sub-motility, which suggests that periodontitis might have a role in idiopathic semen abnormality pathospermia. We evaluated correlations between periodontal infection parameters and the results of sperm analysis of men with idiopathic infertility. In this observational study, semen quality and periodontal status were analyzed for 95 otherwise healthy men attending an andrology unit for sperm analysis. Half the men in the sperm pathology and normozoospermia groups (50.8% and 50%, respectively) had poor periodontal status. Among the 95 participants, 38% had oligozoospermia, 28% had asthenozoospermia, 16% had cryptozoospermia, and 15% were classified as normozoospermic. Sperm pathology category was not associated with frequency of deep periodontal pockets or calculus. Bleeding on probing was significantly lower among men with asthenozoospermia than among those with normozoospermia. Poor periodontal status was not associated with any sperm pathology category or parameter. In contrast with previous findings, the present results indicate that pathospermia and poor semen quality are not associated with periodontal infection in men with idiopathic infertility. (J Oral Sci 58, 247-253, 2016)

show abstract

Section: Discussioncontrasting

confidence: 75%

Association between periodontal status and idiopathic male infertility

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The ROS produced by leukocytes increase the apoptosis in mature human spermatozoa (29). Other authors reported that semen samples with leukocytospermia are more likely to evidence sperm with DNA fragmentation (58,62).…”

Section: Male Genital Tract Infection and Bacteriospermiamentioning

confidence: 98%

“…In vitro studies have shown significant positive correlations between WBCs in semen and deterioration in total sperm count (50), motility (53,57), morphology (50,57,58) and sperm viability (57).…”

Section: Male Genital Tract Infection and Bacteriospermiamentioning

confidence: 99%

The Impact of Bacterial Infections on Human Spermatozoa

Zeyad¹,

Amor²,

Hammadeh³

2017

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

“…Some authors have indicated a lack of any connection between leukocytospermia and diminished semen quality [52][53][54]. However, the vast majority of clinical and experimental in vitro reports have shown a direct association between leukocytospermia and deterioration in semen parameters, in terms of total sperm count [55,56], sperm motility [9,55,[57][58][59][60], sperm morphology [56,59,60], and sperm viability [60]. Moreover, according to some authors, leukocytospermia represents an essential or additional risk factor that needs to be treated if sperm quality is to be improved [61,62].…”

Section: Coli Staphylococcus (S) Aureus Enterococcus (E) Faecalismentioning

confidence: 99%

“…During bacterial semen infection, changes in sperm apoptotic markers can be attributed to both leukocytes and bacteria. The direct relationship between seminal leukocytes and apoptotic sperm characteristics has been postulated in both leukocytospermic [59] and nonleukocytospermic patients [106]; and in both cases, the mediating role of phagocyte-generated ROS was strongly suggested [72,107] www.fhc.viamedica.pl human sperm is the subject of intense research. There are strong premises that the direct contact of bacteria and their toxins with spermatozoa is an initial signal for germ cell death.…”

Section: Apoptosis/necrosismentioning

confidence: 99%

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Frączek

Kurpisz

2015

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

The invasion of the male reproductive tract by microorganisms, and its subsequent consequences for sperm fertilizing potential, has been intensely discussed. The role of the bacteria that are responsible for the colonization and contamination of the male urogenital tract, rather than its infection, in diminished sperm parameters raises the most controversy. There are numerous premises suggesting that bacterial semen infection is associated with male infertility. However, the molecular mechanism by which the fertility is affected is complex and multifactorial, and still presents a puzzle. Some authors have suggested that direct interactions between bacteria and human spermatozoa facilitate sperm immobilization, affect sperm morphology, and thus weaken the ability of sperm to fertilize. On the other hand, the massive infiltration of activated leukocytes into the inflammatory site may be associated with impairment of sperm fertilizing potential, due to oxidative, apoptotic, and immune processes. This review presents current research trends and aims to summarize the present knowledge of semen inflammation and causative bacterial agents in the male urogenital tract, with its consequence on seminological parameters, and male fertility status.

show abstract

The incidence and effect of bacteriospermia and elevated seminal leukocytes on semen parameters

Cited by 126 publications

References 47 publications

Association between periodontal status and idiopathic male infertility

Association between periodontal status and idiopathic male infertility

The Impact of Bacterial Infections on Human Spermatozoa

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Contact Info

Product

Resources

About