The incidence and residual lifetime risk of osteoporosis-related fractures in Korea

Park, Chanmi; Ha, Yong-Chan; Jang, Sunmee; Jang, Suhyun; Yoon, Hyun-Koo; Lee, Yong Seuk

doi:10.1007/s00774-011-0279-3

Cited by 144 publications

(116 citation statements)

References 33 publications

Supporting

Mentioning

115

Contrasting

Order By: Relevance

“…Chinese women are estimated to have much higher residual lifetime and 10 year risks of osteoporotic clinical vertebral and wrist fractures, but the difference in 10 year risks of hip fractures are relatively small between men and women (Table 3 and Figure 1). The estimated risks of osteoporotic fractures in the Chinese population from our study are consistent with those in previous studies which have been found to be lower than those in Caucasians 7,8,[26][27][28][29] and some other Asian populations 9,10 . However, the residual lifetime hip fracture risk at age 50 years was noticeably higher than the earlier estimation for the Chinese population 11 (Table 4).…”

Section: Discussionsupporting

confidence: 93%

Residual lifetime and 10 year absolute risks of osteoporotic fractures in Chinese men and women

Liu

Winzenberg

Chen

et al. 2015

Current Medical Research and Opinion

View full text Add to dashboard Cite

While national data was used wherever possible, regional Chinese hip and clinical vertebral fracture incidence rates were used, wrist fracture rates were taken from a Norwegian study and calibrated to the Chinese population. Other fracture sites like tibia, humerus, ribs and pelvis were not included in the analysis, thus these risks are likely to be underestimates. Fracture risk factors other than age and sex were not included in the model. Point estimates were used for fracture incidence rates, osteoporosis prevalence and mortality rates for the general population.

show abstract

Section: Discussionsupporting

confidence: 93%

Residual lifetime and 10 year absolute risks of osteoporotic fractures in Chinese men and women

Liu

Winzenberg

Chen

et al. 2015

Current Medical Research and Opinion

View full text Add to dashboard Cite

show abstract

“…[1,2] Osteoporosis is associated with fragility fractures, which results in decreased activity, poor quality of life, high mortality and excessive economic burden. [2,3,4,5,6] Korean population is aging and osteoporosis has been one of the highlighted health care concerns in Korea. [6]…”

Section: Introductionmentioning

confidence: 99%

“…[2,3,4,5,6] Korean population is aging and osteoporosis has been one of the highlighted health care concerns in Korea. [6]…”

Section: Introductionmentioning

confidence: 99%

Physicians' Attitudes to Contemporary Issues on Osteoporosis Management in Korea

Lee

Lim

et al. 2014

J Bone Metab

Self Cite

View full text Add to dashboard Cite

BackgroundIn management of osteoporosis, several concerns here have been raised. The current issue included the utilization of dual energy X-ray absorptiometry (DXA) and fracture-risk assessment (FRAX), screening of vitamin D deficiency and secondary osteoporosis, and long-term use of bisphosphonate and calcium supplements. There was no study on physicians' attitude on these current issues in Korea. Therefore, we investigated the physicians' attitude on these issues by survey.MethodsWe administered a 30-item questionnaire to all members of Korean Society for Bone and Mineral Research by email survey form. One hundred participants answered the questionnaire. The questionnaire included the questions about the physicians' attitude to current issues and the barriers to osteoporosis treatment in Korea.ResultsMost physicians used bone densitometry devices (99%) and, central DXA was the most accessible device (95%). Eighty-eight percent were aware of FRAX®, but among them, only 19.3% used it. The main reason for not using FRAX® was the lack of time in their proactive (76%). Screening for vitamin D status and secondary osteoporosis was performed by 59% and 52% of the respondents, respectively. The lack of awareness among patients and high costs of medication were perceived as the most important barriers to osteoporosis management in Korea.ConclusionsThis study provides physicians' perspective to the current issue for diagnostic and treatment of osteoporosis in Korea. To further improve osteoporosis management, educational programs for patients and doctors, and the improvement of reimbursement system should be considered in Korea.

show abstract

“…However, the ICD-10 coding system, established in 1989 by WHO, does include high levels of detail, standardized terminology, and expanded concepts for injuries, and other related factors [16], and is therefore more useful than previous codes used in epidemiologic studies. In addition, we used an age of 50 years or more as an additional criterion to exclude non-OFs, as elsewhere [1,17]. Second,…”

Section: Resultsmentioning

confidence: 99%

A higher serum gamma-glutamyl transferase level could be associated with an increased risk of incident osteoporotic fractures in Korean men aged 50 years or older

et al. 2014

View full text Add to dashboard Cite

With increasing life expectancies in men and greater comorbidity and mortality after hip fractures in men than in women [2], OFs in men will likely become a significant burden on society and healthcare systems in the future.Gamma-glutamyl transferase (GGT) has long been considered a sensitive marker of hepatic dysfunction or excessive alcohol intake [3]. However, accumulating evidence from epidemiological studies has shown that high levels of serum GGT, even within its reference range, can predict the incidence of cardiovascular disease (CVD), diabetes, and hypertension independently of alcohol consumption [4,5]. Although the exact mechanisms that link GGT with these diseases are not fully elucidated, GGT is known to play an A higher serum gamma-glutamyl transferase level could be associated with an increased risk of incident osteoporotic fractures in Korean men aged 50 years or older Abstract. Oxidative stress has detrimental effects on bone metabolism, and gamma-glutamyl transferase (GGT) is known to play an important role in the generation of free radical species through the extra-cellular hydrolysis of glutathione, the main cellular antioxidant. We performed a large longitudinal study with an average follow-up period of 3 years to investigate the association between baseline serum GGT levels and the development of future osteoporotic fractures (OFs) in men. A total of 16,036 Korean men aged 50 years or older who had undergone comprehensive routine health examinations were enrolled. Incident fractures at osteoporosis-related sites (e.g., hip, spine, distal radius, and proximal humerus) that occurred after baseline examinations were identified from the nationwide claims database of the Health Insurance Review and Assessment Service of Korea using selected ICD-10 codes. Among the study subjects, 156 cases (1.0%) developed incident OFs during the study period. The event rate was 32.7 (95% CI = 28.0-38.3) per 10,000 person-years. Multivariable adjusted Cox proportional hazard analyses adjusted for age, body mass index, lifestyle factors, and medical and drug histories revealed that the hazard ratio per standard deviation increase of the baseline GGT levels for the development of incident fractures was 1.115 (95% CI = 1.011-1.230). These data provide the first epidemiological evidence, in support of previous in vitro and animal studies, of the harmful effects of GGT on bone metabolism, and indicate that the serum GGT level may be a useful biomarker of poor bone health outcomes in men.

show abstract

The incidence and residual lifetime risk of osteoporosis-related fractures in Korea

Cited by 144 publications

References 33 publications

Residual lifetime and 10 year absolute risks of osteoporotic fractures in Chinese men and women

Residual lifetime and 10 year absolute risks of osteoporotic fractures in Chinese men and women

Physicians' Attitudes to Contemporary Issues on Osteoporosis Management in Korea

A higher serum gamma-glutamyl transferase level could be associated with an increased risk of incident osteoporotic fractures in Korean men aged 50 years or older

Contact Info

Product

Resources

About