The incidence and risk factors of postpartum diabetes in women from Bangladesh, India and Sri Lanka (South Asia) with prior gestational diabetes mellitus: Results from the LIVING study

Gupta, Yashdeep; Kapoor, Deksha; Lakshmi, Josyula K.; Praveen, Devarsetty; Santos, Joseph Alvin; Billot, Laurent; Naheed, Aliya; de Silva, H. Asita; Gupta, Ishita; Farzana, Noshin; John, Renu; Ajanthan, Saumiyah; Bhatla, Neerja; Desai, Ankush; Pathmeswaran, Arunasalam; Prabhakaran, Dorairaj; Teede, Helena; Zoungas, Sophia; Patel, Anushka; Tandon, Nikhil

doi:10.1016/j.diabres.2023.110893

Cited by 2 publications

(2 citation statements)

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“…Given that GDM diagnosed using IADPSG criteria is milder with a lower risk of future diabetes than that with other criteria, identifying high-risk women with a history of IADPSG criteria becomes even more crucial for judicious use of limited resources. [10][11][12] Given the high risk of developing diabetes after GDM in South Asia and the limited data in LMICs using IADPSG criteria, we aimed to complete a Lifestyle Intervention IN Gestational Diabetes (LIVING) trial substudy to explore associations between type and number of abnormal glucose values on antenatal OGTT with postpartum diabetes in South Asian women diagnosed with past GDM using IADPSG criteria.…”

Section: Introductionmentioning

confidence: 99%

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Antenatal oral glucose tolerance test abnormalities in the prediction of future risk of postpartum diabetes in women with gestational diabetes: Results from the LIVING study

Gupta,

Kapoor,

Lakshmi

et al. 2024

Journal of Diabetes

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ObjectivesTo explore associations between type and number of abnormal glucose values on antenatal oral glucose tolerance test (OGTT) with postpartum diabetes in South Asian women diagnosed with gestational diabetes (GDM) using International Association of the Diabetes and Pregnancy Study Groups criteria.MethodsThis post‐hoc evaluation of the Lifestyle Intervention IN Gestational Diabetes (LIVING) study, a randomized controlled trial, was conducted among women with GDM in the index pregnancy, across 19 centers in Bangladesh, India, and Sri Lanka. Postpartum diabetes (outcome) was defined on OGTT, using American Diabetes Association (ADA) criteria.ResultsWe report data on 1468 women with GDM, aged 30.9 (5.0) years, and with median (interquartile range) follow‐up period of 1.8 (1.4–2.4) years after childbirth following the index pregnancy. We found diabetes in 213 (14.5%) women with an incidence of 8.7 (7.6–10.0)/100 women‐years. The lowest incidence rate was 3.8/100 women years, in those with an isolated fasting plasma glucose (FPG) abnormality, and highest was 19.0/100 women years in participants with three abnormal values. The adjusted hazard ratios for two and three abnormal values compared to one abnormal value were 1.73 (95% confidence interval [CI], 1.18–2.54; p = .005) and 3.56 (95% CI, 2.46–5.16; p < .001) respectively. The adjusted hazard ratio for the combined (combination of fasting and postglucose load) abnormalities was 2.61 (95% CI, 1.70–4.00; p < .001), compared to isolated abnormal FPG.ConclusionsRisk of diabetes varied significantly depending upon the type and number of abnormal values on antenatal OGTT. These data may inform future precision medicine approaches such as risk prediction models in identifying women at higher risk and may guide future targeted interventions.image

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Section: Introductionmentioning

confidence: 99%

“…Given that GDM diagnosed using IADPSG criteria is milder with a lower risk of future diabetes than that with other criteria, identifying high‐risk women with a history of IADPSG criteria becomes even more crucial for judicious use of limited resources. 10 , 11 , 12 …”

Section: Introductionmentioning

confidence: 99%