The incidence and risk factors for developing depression after being diagnosed with inflammatory bowel disease: a cohort study

Panara, Ami; Yarur, Andrés; Rieders, Brandon; Proksell, Siobhan; Deshpande, Amar R.; Abreu, María T.; Sussman, Daniel A.

doi:10.1111/apt.12669

Cited by 134 publications

(142 citation statements)

References 30 publications

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“…Patients with IBD have been shown to have lower psychological wellbeing and higher distress than controls [9]. This stress induces changes in GI function, such as increased intestinal permeability and visceral sensitivity, and altered GI gut motility, which could lead to IBD symptoms [2,11,22]. Especially early life stress, such as maternal separation, has a large impact on inflammation, intestinal barrier function and dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis in rodents and animals [23].…”

Section: Psychosocial Factors Stressmentioning

confidence: 99%

“…Flare up of active disease in IBD is related to stressful life events, such as domestic stress, and high perceived stress during the previous 3 month period, as shown by a study comparing 174 IBD patients experiencing a flare to 209 IBD patients without a flare up [25]. Psychological stress can also be a side effect of treatment, such as corticosteroids [2]. Stress induces, aggravates and influences the course of IBD occurs through its effect on the brain-gutaxis (BGA), which consists of all the connections between the brain and the gut and include the HPA axis, autonomic nervous system, central nervous system, corticotrophin-releasing factor system, and the intestinal response [11,23].…”

Section: Psychosocial Factors Stressmentioning

confidence: 99%

“…Inflammatory bowel diseases (IBD), which include Crohn's disease (CD) and Ulcerative Colitis (UC), are chronic and relapsing diseases resulting from "an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host" [1,2,3]. IBD involves chronic mucosal inflammation and increased intestinal permeability [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…It is known that exposure to stress is a major risk factor in the pathogenesis of IBD, and that it not only has effects on the course of IBD, but also on the psychological well-being of IBD patients [9,11]. Indeed, IBD patients suffer from mental disorders such as depression and anxiety significantly more often than the general population [2,12,13]. They also have maladaptive coping styles, fears, worries and feelings of guilt [8,9,14].…”

Section: Introductionmentioning

confidence: 99%

“…They also have maladaptive coping styles, fears, worries and feelings of guilt [8,9,14]. Likewise, IBD patients have a lower health related quality of life (HRQoL) than the general population, which is influenced by extreme fatigue, and the early age of onset and chronic course of IBD [2,3,15,16]. The worldwide incidence of UC lies between 0.5-24.5/100 000 persons, while that of CD falls between 0.1-16/100 000 persons [17].…”

Section: Introductionmentioning

confidence: 99%

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"Role of Psychosocial Factors on the Course of Inflammatory Bowel Disease and Associated Psychotherapeutic Approaches. A Fresh Perspective and Review"

Banan¹

2015

GHOA

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In this review article we seek to provide a fresh prospective on the role of psychosocial factors such as stress, anxiety, and depression, in the course of Inflammatory Bowel Diseases (IBD). IBD patients suffer from depression and anxiety at higher rates than the general population. Psychological stressors adversely affect the course of IBD through activation and possible dysfunction of the Brain-Gut-Axis. The mechanisms by which psychological factors increase mucosal inflammation, disrupt the intestinal barrier, and thereby worsen IBD symptoms are not well understood. This is a new and upcoming area of research that needs more attention because of its importance in managing and treating patients with IBD while also reducing costs associated with these disorders. Therefore, in this article we also seek to explore treatment options that target these psychological factors. Interventions include both pharmacological and nonpharmacological psychotherapeutic approaches. Whereas some of these therapies improve IBD symptoms, many also improve depression, anxiety, stress symptoms, fatigue, relapse rate, and Quality of Life (QOL) in both adults and children with IBD. These psychological factors are important determinants of health related quality of life (HRQOL) and therefore are important symptoms to treat alongside the IBD symptoms.

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Section: Psychosocial Factors Stressmentioning

confidence: 99%

Section: Psychosocial Factors Stressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

"Role of Psychosocial Factors on the Course of Inflammatory Bowel Disease and Associated Psychotherapeutic Approaches. A Fresh Perspective and Review"

Banan¹

2015

GHOA

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Microalgae‐Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression

Zhong,

Jin,

Wang

et al. 2024

Advanced Materials

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Patients diagnosed with inflammatory bowel disease (IBD) exhibit a notable prevalence of psychiatric disorders, such as anxiety and depression. Nevertheless, the etiology of psychiatric disorders associated with IBD remains uncertain, and an efficacious treatment approach has yet to be established. Herein, we propose an oral hydrogel strategy (SP@Rh‐gel) for co‐delivery of Spirulina platensis and rhein to treat IBD and IBD‐associated anxiety and depression by modulating the microbiota‐gut‐brain axis. SP@Rh‐gel improves the solubility, release characteristics and intestinal retention capacity of the drug, leading to a significant improvement in the oral therapeutic efficacy. Oral administration of SP@Rh‐gel inhibits NF‐κB‐caspase‐1 signaling pathway to reduce intestinal inflammation and rebalances the disrupted intestinal microbial community to maintain intestinal homeostasis. Furthermore, SP@Rh‐gel maintains intestinal barrier integrity and reduces the release of pro‐inflammatory cytokines and lipopolysaccharides and their entry into the hippocampus through the blood‐brain barrier, thereby inhibiting neuroinflammation and maintaining neuroplasticity. SP@Rh‐gel significantly alleviates the colitis symptoms, as well as anxiety‐ and depression‐like behaviors, in a chronic colitis mouse model. This study demonstrates the significant involvement of the microbiota‐gut‐brain axis in the development of IBD with psychiatric disorders and proposes a safe, simple, and highly efficient therapeutic approach for managing IBD and comorbid psychiatric disorders.This article is protected by copyright. All rights reserved

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A Metal–Polyphenol‐Based Antidepressant for Alleviating Colitis‐Associated Mental Disorders

Wang,

et al. 2024

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Emerging evidence suggests that patients with inflammatory bowel diseases (IBDs) are predisposed to psychosocial disturbances, such as depression and anxiety. Regrettably, clinical antidepressants exhibit unsatisfactory therapeutic efficacy in IBD‐associated psychosocial disturbances, primarily attributed to the inherent intestinal disorders and intricate bidirectional relationship between the gut and the brain. Herein, we report a metal–polyphenol‐based antidepressant to alleviate mental disorders in dextran sulfate sodium‐induced experimental acute colitis mice via modulating the microbiota–gut–brain axis. The antidepressant, termed CSMTC, comprises a core of melittin‐encapsulated natural antioxidant enzymes (i.e., catalase and superoxide dismutase) and a protective shell composed of tannic acid–cerium ion network. Upon oral administration to colitis mice, CSMTC can effectively restore colonic redox balance, reinforce the intestinal barrier, modulate gut microbiota composition, maintain the blood–brain barrier integrity, and regulate systemic immune responses. Notably, behavioral test results reveal that CSMTC significantly alleviates the colitis‐associated mental disorder (e.g., depression‐like behavior) via the microbiota–gut–brain axis by reducing neuroinflammation, enhancing hippocampal neural plasticity, modulating hippocampal immune responses, and restoring neurotransmitter homeostasis. This work may have implications for the development of new nanodrugs for treating inflammation‐associated complications.

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The incidence and risk factors for developing depression after being diagnosed with inflammatory bowel disease: a cohort study

Abstract: SUMMARY BackgroundStudies have found that depression is more frequent in patients with inflammatory bowel disease (IBD) than the general population. Clinicians are now trying to pinpoint risk factors for psychological impairment in the IBD population.

Cited by 134 publications

References 30 publications

"Role of Psychosocial Factors on the Course of Inflammatory Bowel Disease and Associated Psychotherapeutic Approaches. A Fresh Perspective and Review"

"Role of Psychosocial Factors on the Course of Inflammatory Bowel Disease and Associated Psychotherapeutic Approaches. A Fresh Perspective and Review"

Microalgae‐Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression

A Metal–Polyphenol‐Based Antidepressant for Alleviating Colitis‐Associated Mental Disorders

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