The Incidence and Severity of Retrolental Fibroplasia in Relation To Possible Causative Factors*

Retrolental Fibroplasia in Association With Mental Defect

“…The birthweights of our series are compared with a control group of 23 children without retrolental fibroplasia, at present in the Fountain Hospital, who weighed less than 5 lb (2,270 g.) at birth. Zacharias, Reynolds, Chisholm, and King (1954) have shown that, in America between 1934 and 1952, there was a three-fold increase in the number of children weighing 4 lb (1,800 g.) or less who survived, and it seems reasonable therefore to postulate that a proportion of these had some degree of neural damage or defect associated with prematurity, and that the association of retrolental fibroplasia in some of them might be purely coincidental. Douglas (1956), in a detailed study, has been following up all the premature children born in the first week of March, 1946. Out of 676 premature babies, he found that six were educationally subnormal, whereas there were only two so affected in his carefully matched group of controls.…”

Chapter I: Physical Growth

“…Several workers produced or evaluated evidence pertaining to the rate of oxygen administration in the etiology of retrolental fibroplasia (1,14,15,16,17,80,89,93,113,118,122,123,124,125,155,162,177,179,187,189,219,252,259,260,342).…”

Comparison of two automated oxygen controllers in oxygen targeting in preterm infants during admission: an observational study

“…Caregivers in the neonatal intensive care unit (NICU) must continuously maintain a fragile balance between administering too much and too little supplemental oxygen to preterm infants to prevent morbidity and mortality. Several neonatal morbidities have been linked to a disturbance in this balance, intermittent hypoxia being associated with retinopathy of prematurity (ROP),1 neurodevelopmental impairment and death,2 and hyperoxia with ROP 3…”