The incidence and survival of cervical, ovarian, and endometrial cancer in Korea, 1999-2017: Korea Central Cancer Registry

Abstract

Objective The three major gynecologic cancers are cervical, endometrial, and ovarian cancer. This study aimed to describe the 19-year trends and survival rates in cervical, endometrial, and ovarian cancer in a Korean female population.Methods We searched the Korea Central Cancer Registry to identify patients with gynecologic cancer between 1999 and 2017. Age-standardized rates and annual percent changes were calculated. The relative survival rate (RSR) was reported by histology, age, and stage for each gynecological cancer.Results The total number of cervical, endometrial, primary peritoneal, ovarian epithelial, fallopian tube (POFT) cancer was 134,863, with the number of cases increasing every year: 6,077 in 1999 to 8,011 in 2017. The incidence of cervical cancer has decreased; however, that of POFT and endometrial cancer has increased. The 5-year RSR of cervical, POFT, and endometrial cancer was reported to be 80.8%, 61.4%, and 88.1%, respectively. In the case of cervical cancer, squamous cell carcinoma showed better survival than other histology (82.8% vs. 73.5%). Furthermore, in the case of endometrial cancer, endometrioid histology had substantially better 5-year RSR than the others (93.2% vs. 76.5%). Contrastingly, in the case of ovarian cancer, serous carcinoma had worse 5-year RSR than other types of histology.Conclusion The incidence rates for gynecologic cancers increased from 2005 to 2017, with an annual increase of 2.76 per year until 2017. Endometrial cancer had the highest RSR, while ovarian cancer had the lowest. Active cancer screening and the introduction of effective treatments might have contributed to the improved RSRs of gynecologic cancers.

Identification of Prognostic Markers of Gynecologic Cancers Utilizing Patient-Derived Xenograft Mouse Models

“…In Korea, the incidence rates for gynecologic cancers increased annually from 2005 until 2017. The 5-year relative survival rates from ovarian, cervical, and endometrial cancer were reported to be 61%, 81%, and 88%, respectively [3]. Gynecologic cancers frequently occur in postmenopausal women, with a high incidence rate in women 2 of 16 aged 50-60 years [4,5].…”

Safety and efficacy study of laparoscopic or robotic radical surgery using an endoscopic stapler for inhibiting tumour spillage of cervical malignant neoplasms evaluating survival (SOLUTION): a multi-centre, open-label, single-arm, phase II trial protocol

“…Cervical cancer is the fourth frequent cancer in women [ 1 ], and in case of localized disease, the 5-year survival rate is 92.5%, showing a relatively good prognosis [ 2 ]. Treatment of early-stage cervical cancer is based on radical hysterectomy and pelvic lymphadenectomy, and adjuvant concurrent radiotherapy (CCRT) may be performed depending on risk factors.…”

Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in Korea

“…Due to the absence of disease-specific symptoms and screening tools, most ovarian cancer cases are diagnosed at an advanced stage, resulting in high recurrence and mortality rates despite initial treatment. While the incidence rate of ovarian cancer is decreasing in the United States ( 2 ), it has progressively increased in Korea since 1999 ( 3 ), accompanied by a Western lifestyle and an increase in obese women ( 4 ). Ovarian cancer comprises various histological entities with distinct etiologies, molecular biology, and clinical features.…”

“…To date, only few studies have reported nationwide survival outcomes of primary OCCC in Korea ( 3 , 16 ). However, none of these studies directly compared the baseline characteristics and survival of OCCC with those of other histologic subtypes.…”