The incidence of acute myeloid leukemia in Calgary, Alberta, Canada: a retrospective cohort study

Abstract

BackgroundThe incidence rate of acute myeloid leukemia (AML) was determined in the Calgary Metropolitan Area, a major Canadian city.MethodsData from all patients diagnosed with AML between January 1, 2011 and December 31, 2015 were retrieved from a single, centralized cancer cytogenetics laboratory for bone marrow samples, the sole diagnostic facility of its kind in Southern Alberta.ResultsThe calculated incidence rate was 2.79 cases per 100,000 person-years with a median age of 60, slightly lower than previously published data. The age-standardized incidence rate for Canada was 3.46 cases per 100,000 person-years. The higher value is reflective of Calgary’s younger population compared to the rest of Canada. Higher male incidence and greatest incidence occurring at approximately the age of 85 is similar to data from other developed countries. The lower incidence rates and median age of diagnosis, in comparison with that of other high-income nations, may be due to differences in the proportion of aging citizens in the population.ConclusionThis is the first published incidence rate of acute myeloid leukemia (AML) in Canada across all age groups.

Analysis of acute myeloid leukemia incidence and geographic distribution in Canada from 1992 to 2010 reveals disease clusters in Sarnia and other industrial US border cities in Ontario

“…12 Furthermore, relatively low incidence rate of AML, compared with the national average, was recently reported in Southern Alberta (27.9 cases per 1 million individuals per year from 2011 to 2015). 18 The analysis of AML incidence rates by city corroborated the provincial trends identifying 5 cities in Ontario located near the US border-Sarnia, Sault Ste. Marie, Thunder Bay, St. Catharines, and Hamiltonwith significantly higher incidence rates than the Canadian average ( Fig.…”

“…For instance, a steady increase in the incidence of AML in Ontario between 1965 and 2000 has been reported . Furthermore, relatively low incidence rate of AML, compared with the national average, was recently reported in Southern Alberta (27.9 cases per 1 million individuals per year from 2011 to 2015) …”

“…Another case‐control study in Northern Italy identified a correlation between exposure to low levels of benzene released from motorized traffic and an increased risk of developing childhood leukemia . Several other cluster studies across North America, South America, and Europe identified areas with elevated incidences of AML but did not specify the precise risk factors …”

“…16 Several other cluster studies across North America, South America, and Europe identified areas with elevated incidences of AML but did not specify the precise risk factors. 6,7,[17][18][19] In this study, we conducted an extensive epidemiological analysis of AML burden across all provinces and territories in Canada from 1992 to 2010 and analyzed the geographical distribution of AML patients, revealing geographic clustering for this malignancy.…”

Prospective evaluation of clinical symptoms of chemotherapy‐induced oral mucositis in adult patients with acute leukemia: A preliminary study

“…Leukemia is a kind of hematological cancer that is caused by an overproduction of white blood cell (WBC)-forming tissues resulting in a marked increase in circulating immature or abnormal WBCs (Shysh et al, 2017). Leukemia is an uncommon disease, and the crude incidence rate per 100,000 was 6.4 in a Korean population (Jung, Won, Kong, Lee, & The Community of Population-Based Regional Cancer, 2018).…”