The Incidence of Adverse Drug Reaction Spontaneously Reported in a General Hospital

Abstract

Background : Despite various activities for improving spontaneous adverse drug reaction (ADR), studies on the incidence of ADR are insufficient. Therefore, we intend to improve the ADR activity by calculating the incidence rate reported by a hospital through the data warehouse and selecting drugs requiring intensive monitoring. Methods :This was a retrospective frequency analysis study. A total of 949 ADR cases reported spontaneously were collected, and the ADR incidence rate was calculated by data warehouse query. The collecting items are the reporting date, gender, age group, medical department, drug name, ingredient name, drug classification name, outcomes, severity, and causality.Results : Of all cases, the frequency in the medical department was surgical 482 (50.8%), internal medical 188 (19.8%), and others 282 (29.7%). The frequency was higher among women (63.3%) and 60s (24.2%). The top five frequency of ADR ingredients was tramadol (238), cefotetan (62), pethidine (58), iohexol (36), ceftriaxone (31). The incidence rate of ADR reports associated with each drug are as follow: tramadol injection 0.86%, pethidine injection 0.24%,