The Incidence of Bladder Tumours in a Dyestuffs Factory

Scott, T. S.

doi:10.1136/oem.9.2.127

Cited by 20 publications

(8 citation statements)

References 3 publications

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“…Benzidine and beta-naphthylamine are dye intermediates which have been shown to be human bladder carcinogens (7,19,33). One of the two tanneries in our study, tannery B, showed detectable concentrations of benzidine in bulk dyes in the dye room.…”

Section: Discussionmentioning

confidence: 78%

Mortality of chrome leather tannery workers and chemical exposures in tanneries.

Stern¹,

Beaumont²,

Halperin³

et al. 1987

Scand J Work Environ Health

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95 Cllo of the cohort. Potential hazardous workplace exposures varied with department and included nitrosamines, chromate pigments, benzidine-based direct dyestuffs, formaldehyde, leather dust, and aromatic organic solvents. Mortality from all causes combined was lower than expected for each tannery, the standardized mortality ratio being 81 for one and 93 for the other. Deaths from cancer of each site, including the lung, were also lower than expected compared to those of either the population of the United States or of local state rates. A significant excess of deaths was observed, however, due to accidental causes in one tannery and cirrhosis of the liver, suicide, and alcoholism in the other. These excesses did not appear to be causally associated with occupational exposures. Th e findings of this study are consistent with those of the only other mortality investigation of leather tannery employees.

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Section: Discussionmentioning

confidence: 78%

Mortality of chrome leather tannery workers and chemical exposures in tanneries.

Stern¹,

Beaumont²,

Halperin³

et al. 1987

Scand J Work Environ Health

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“…İ1kin anilinin kanserojen olduğu ileri sürülmüş iken (I 05) bu maddenin sıçanlarda tümör hasıl etmeyişi (44), şüphe doğurmuş ve kısa zaman sonra, anilinin sentezlenmesi sırasında, yan ürün olarak meydana gelip havaya karışan B-naftilamin (veya a-naftilamin'dc olabilir), tozlarının teneffüs edilmesi sonu esas karsin~jcn olarak işçi-lerde kese kanserine sebep olduğu deneylerle ispat edilmiştir. (25,27,44,113). Bundan sonra birçok Azo-Boya maddeleri (91,95,120), Aromatik Nitro-Bileşikleri (34)'nin de aynı etkiyi yaptıkları benzeri deneylerle gösterilmiştir ki böylelikle de çeşitli endüstri sahalarındaki işçilerde fazla nisbetlerde ( % 4.5-i00) ortaya çıkan sidik kesesi kanserlerinin esas sebepleri anlaşılmaktadır (6 i,69).…”

Section: A Sidik Kesesi Tümörlerinin })Iyoloji Ve Lc-pidemiyolojisiunclassified

SİDİK KESESİ TÜMÖRLERİNİN ETİYOLOJİ, EPİDEMİYOLOJİ, KLİNİK ve PATOLOJİSİ KONULARINDA SON GÖRÜŞLER

Ertürk¹

1974

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…This is a reasonable argument, but it must begin to lose some of its validity as more and more coincidences are uncovered, and as a biologically plausible explanation evolves. The six occupational groups in (Adelstein, 1972: Anthony and Thomas, 1970: Case, 1966Case et al, 1954;Goldblatt, 1949;HM Chief Inspector of Factories, 1965;Melick et al, 1955;Wynder, Onderdonk, and Mantel, 1963;Scott, 1952). Pigment and paint manufacture (Case and Pearson, 1954;HM Chief Inspector of Factories, 1965;Ministry of Labour, 1966).…”

mentioning

confidence: 99%

Bladder tumours and occupation: a coroner's notification scheme

Veys

1974

Occupational and Environmental Medicine

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Veys, C. A. (1974).British Journal of Industrial Medicine,31, 65-71. Bladder tumours and occupation: a coroner's notification scheme. The disease of bladder cancer accounted for 2 763 male and 1 107 female deaths in England and Wales during 1971. How much of this total is influenced by aetiological factors in the working environment is still largely unknown and is only now beginning to be studied. In order to elucidate this question further, a coroner's notification scheme for all bladder tumours occuring within a defined geographical area was started in 1965. Details of all persons dying, on whose death certificate a bladder tumour was mentioned, were notified to the coroner's office within a six-year period (1965-70). A necropsy was carried out in almost all cases. A subsequent searching enquiry into the lifetime occupational history was conducted and this was then related to two industrial check-lists previously drawn up, on which the occupations listed exhibited either a true cause and effect relationship, or were merely associated in statistical terms. The finding that about 20% of persons dying of this disease had a suspicious occupational history of exposure to a carcinogen was broadly in agreement with some other recent surveys whose methodology was different. In only one third of these cases, however, could the working environment be directly and realistically implicated. The study supports the conclusion that the importance of occupational factors in the aetiology of bladder tumours has hitherto been underestimated.

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The Incidence of Bladder Tumours in a Dyestuffs Factory

Cited by 20 publications

References 3 publications

Mortality of chrome leather tannery workers and chemical exposures in tanneries.

Mortality of chrome leather tannery workers and chemical exposures in tanneries.

SİDİK KESESİ TÜMÖRLERİNİN ETİYOLOJİ, EPİDEMİYOLOJİ, KLİNİK ve PATOLOJİSİ KONULARINDA SON GÖRÜŞLER

Bladder tumours and occupation: a coroner's notification scheme

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