The incidence of "coring" during aspiration of propofol from a 50-ml vial

The impact of needle size and angle on rubber coring after multiple puncturing of multi-dose propofol vial rubber stoppers

“…Propofol (Bromobutyl rubber stopper) is an anesthesia commonly used in practice which is housed in a multi-dose vial. Multiple puncturing through the rubber stoppers of the vial can produce a rubber core which is a small foreign object floating in the liquid medication [ 1 , 2 ].…”

“…Multiple puncturing of the rubber stoppers of multi-doses vials can produce a rubber core, a small foreign object floating in the liquid medication ( Figure 1 ). The incidence of coring of rubber stoppers has been estimated to range overall from 0-40%, depending on the study methods and the medical devices used to pierce the rubber stopper [ 1 , 2 ]. A previous study reported that particles larger than 6–8 μm in diameter are able to enter the patient's vessels.…”

Possibility and Risk of Medication Vial Coring in Interventional Spine Procedures

“…Cored particles might also be more easily detectable in nonparticulate medications such as dexamethasone, as compared with more dense solutions such as triamcinolone. In addition, cored particles could be mistaken for air bubbles [10]. Therefore, even trained visual inspectors in pharmaceutical industries may not detect some of the very small particles, especially those smaller than 200 μm [22].…”

Rubber fragments in 100-ml mepivacaine vials: a caution

“…We previously reported the incidence of coring during the use of 50-ml propofol vials [1]. In the operating room, anesthesiologists use vials of local anesthetic as frequently as they use propofol vials.…”