The Incidence of Esophageal Bolus Impaction

Larsson, Helén; Bergquist, Henrik; Bove, Mogens

doi:10.1177/0194599810392655

Cited by 41 publications

(22 citation statements)

References 15 publications

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“…Similar results have been demonstrated with 330 cases of EoE reported in four additional studies with increase in the diagnosis of EoE in pollen seasons 68-71 . Furthermore, Larson in a series of 313 esophageal bolus impactions found an increase in cases in the summer and fall 72 . However, Sorsen and colleagues evaluation of 753 endoscopies in adults with 44 patients having EoE did not find any seasonality to the diagnosis.…”

Section: The Role Of Aeroallergens In Eoementioning

confidence: 99%

An allergist's perspective to the evaluation of Eosinophilic Esophagitis

Spergel

2015

Best Practice & Research Clinical Gastroenterology

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Eosinophilic Esophagitis (EoE) is a classic atopic disease as it shares features with other atopic disease on all levels including pathogenesis, genetics, epidemiology, and treatment options. EoE has elements of Th2 pathogenesis with increase levels of Th2 cytokines (IL4, 5, and 13). In addition, it shares atopic genetic risk factors including thymic stromal lymphopoietin (TSLP) loci as a risk factor in genome wide association studies. EoE patients have a higher rate of other atopic disease (asthma, allergic rhinitis and food allergy) compared to the general population indicating their atopic phenotype. Like asthma, atopic dermatitis or food allergy, EoE has increased in the last 20 years. Treatment options include the basic principle of other atopic diseases include using topical steroids or avoidance of the triggers (food or pollen). An allergist provides a critical role as they are experts in the treatment of atopic disease including avoidance strategies.

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Section: The Role Of Aeroallergens In Eoementioning

confidence: 99%

An allergist's perspective to the evaluation of Eosinophilic Esophagitis

Spergel

2015

Best Practice & Research Clinical Gastroenterology

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“…Several studies have found changing clinical symptoms during peak pollen seasons, especially in those with concomitant allergic rhinitis. 8–10 The frequency of diagnosis also appears to increase during pollen seasons, with a lower frequency found in winter. 11–14 However, other studies have found no clear link among aeroallergen sensitization, symptom onset, and seasonal diagnosis of EoE.…”

Section: Introductionmentioning

confidence: 99%

Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis

Pesek

Rettiganti

O’Brien

et al. 2017

Annals of Allergy, Asthma & Immunology

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Background: In children with eosinophilic esophagitis (EoE) foods are the most common disease triggers, but environmental allergens are also suspected culprits. Objective: To determine the effects of environmental allergen sensitization on response to treatment in children with EoE in the southeastern United States. Methods: Patients 2 to 18 years old who were referred to the Arkansas Children’s Hospital Eosinophilic Gastrointestinal Disorders Clinic from January 2012 to January 2016 were enrolled in a prospective, longitudinal cohort study with collection of demographics, clinical symptoms, medical history, allergy sensitization profiles, and response to treatment over time. Comparisons were made between complete responders (peak esophageal eosinophil count <15 per high-power field [HPF]) and nonresponders (>25 eosinophils per HPF) after treatment with diet elimination alone, swallowed corticosteroids alone, or diet elimination and swallowed corticosteroids. Sensitization patterns to environmental allergens found in the southeastern United States were analyzed for the effect on treatment response. Results: A total of 223 individuals were enrolled. Of these, 182 had environmental allergy profiling and at least one endoscopy while receiving proton pump inhibitor (PPI) therapy. Twenty-nine individuals had PPI-responsive EoE and were excluded from further analysis, leaving 123 individuals with none-PPI-responsive EoE who were further analyzed; 72 (58.5%) were complete responders and 33 (26.8%) were nonresponders. Seventeen individuals (13.8%) were partial responders (≥ 1 but ≤ 25 eosinophils per HPF) and excluded from further analysis. Nonresponders were more likely to be sensitized to perennial allergens (P = .02). There was no significant difference in response based on seasonal allergen sensitization. Individuals with mold or cockroach sensitization were more likely to fail combination diet and swallowed corticosteroid treatment (P = .02 and P = .002). Conclusion: Perennial allergen and mold sensitization may lead to nonresponse to EoE treatment in some patients. Additional studies are needed to further understand the effect of environmental allergens on EoE. Trial Registration: http://ClinicalTrials.gov identifier: NCT01779154.

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“…La incidencia fue 33 casos/100,000 habitantes y año. Esta cifra es significativamente mayor que la publicada en la literatura, donde la incidencia estimada es de 13 a 20 casos/100,000 habitantes y año 9,10 . De hecho, se ha observado que el área geográfica tiene influencia sobre los CE y más concretamente sobre la impactación por bolo alimenticio 9,11 .…”

Section: Discussionunclassified