The Incidence of Hypothyroidism Following Hemithyroidectomy in a Tertiary Academic Center in Saudi Arabia

Alhozali, Amani; Alqutub, Abdulsalam; Ahmed, Mohammed S.; Alsulami, Omar A; Alfawaz, Khaled; Faidah, Hassan; AlNoury, Omar; Alquliti, Nawaf; Merdad, Mazin

doi:10.7759/cureus.35703

Cited by 2 publications

(2 citation statements)

References 16 publications

(28 reference statements)

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“…Both scores were signi cant predictors of readmission within 60 days of discharge. Previous reports con rmed that the ASA score is closely linked to predicting readmissions and is positively associated with increased readmission rates (14,28,29). Additionally, the CIRS comorbidity score has been previously used in head and neck cancer patients, with higher scores suggesting worsening baseline health (13,14,30).…”

Section: Discussionmentioning

confidence: 99%

Rate, Causes, and Predictors of Readmission within 60 Days Following Total Laryngectomy

Rammal,

Alqutub,

Alsulami

et al. 2023

Preprint

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Background: The readmission rate is a metric for quality of care. Total laryngectomy (TL) is a complex procedure, and patients undergoing TL are at high risk for readmission, which exposes them to hospital-acquired complications. We aimed to identify the rate, causes, and predictors of hospital readmission within 60 days after discharge following TL. Methods: In this retrospective study, we included all patients undergoing TL in a single tertiary care center between 2008 and 2022. Patient charts were reviewed for demographics, comorbidities, and causes for readmission. Results: Of 83 patients who underwent TL, 12 (14.5%) were readmitted within 60 days. Common causes were surgical site infection (33.33%) and mucocutaneous fistula (25%). Significant predictors for readmission were tobacco use (P = 0.003), African ethnicity (P = 0.004), being unmarried (P < 0.001), lower preoperative serum albumin (P < 0.001), higher preoperative TSH (P = 0.03), higher preoperative neutrophil count (P = 0.035), higher American Society of Anesthesiology (ASA) score (P = 0.028), and higher Cumulative Illness Rating Scale (CIRS) score (P = 0.029). Conclusion: The rate of readmission after total laryngectomy was 14.5%. Frequent causes include wound infection and fistulas. Predictors include preoperative hypoalbuminemia, hypothyroidism, African ethnicity, being unmarried, tobacco use, and a higher baseline burden of comorbidities. Such factors can be targeted to reduce hospital readmission rates.

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Section: Discussionmentioning

confidence: 99%

Rate, Causes, and Predictors of Readmission within 60 Days Following Total Laryngectomy

Rammal,

Alqutub,

Alsulami

et al. 2023

Preprint

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“…The quality assessment of the cohort studies included in our review was conducted by the National Institutes of Health (NIH) ( 16 ). Studies underwent an assessment where scores were assigned, determining their quality.…”

Section: Introductionmentioning

confidence: 99%

Histopathological predictors of lymph node metastasis in oral cavity squamous cell carcinoma: a systematic review and meta-analysis

Alqutub,

Bakhshwin

et al. 2024

Front. Oncol.

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ObjectivesLymph node metastasis (LNM) is the most significant parameter affecting overall survival in patients with oral cavity squamous cell carcinomas (OCSCC). Elective neck dissection (END) is the standard of care in the early management of OCSCC with a depth of invasion (DOI) greater than 2-4 mm. However, most patients show no LNM in the final pathologic report, indicating overtreatment. Thus, more detailed indicators are needed to predict LNM in patients with OCSCC. In this study, we critically evaluate the existing literature about the risk of different histological parameters in estimating LNM.MethodsA systematic review was conducted using PRISMA guidelines. PubMed, Web of Science, Cochrane, and Scopus were searched from inception to December 2023 to collect all relevant studies. Eligibility screening of records was performed, and data extraction from the selected studies was carried out independently. Inclusion in our systematic review necessitated the following prerequisites: Involvement of patients diagnosed with OCSCC, and examination of histological parameters related to lymph node metastasis in these studies. Exclusion criteria included animal studies, non-English articles, non-availability of full text, and unpublished data.ResultsWe included 217 studies in our systematic review, of which 142 were eligible for the meta-analysis. DOI exceeding 4 mm exhibited higher risk for LNM [Risk ratio (RR) 2.18 (1.91-2.48), p<0.00001], as did perineural invasion (PNI) [RR 2.04 (1.77-2.34), p<0.00001], poorly differentiated tumors [RR 1.97 (1.61-2.42), p<0.00001], lymphovascular invasion (LVI) [RR 2.43 (2.12-2.78), p<0.00001], groups and single pattern of invasion [RR 2.47 (2.11-2.89), p<0.00001], high tumor budding [RR 2.65 (1.99-3.52), p<0.00001], tumor size over 4 cm [RR 1.76 (1.43-2.18), p<0.00001], tumor thickness beyond 4 mm [RR 2.72 (1.91-3.87), p<0.00001], involved or close margin [RR 1.73 (1.29-2.33), p = 0.0003], and T3 and T4 disease [RR 1.98 (1.62-2.41), p <0.00001].ConclusionOur results confirm the potential usefulness of many histopathological features in predicting LNM and highlight the promising results of others. Many of these parameters are not routinely incorporated into pathologic reports. Future studies must focus on applying these parameters to examine their validity in predicting the need for elective neck treatment.

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The Incidence of Hypothyroidism Following Hemithyroidectomy in a Tertiary Academic Center in Saudi Arabia

Cited by 2 publications

References 16 publications

Rate, Causes, and Predictors of Readmission within 60 Days Following Total Laryngectomy

Rate, Causes, and Predictors of Readmission within 60 Days Following Total Laryngectomy

Histopathological predictors of lymph node metastasis in oral cavity squamous cell carcinoma: a systematic review and meta-analysis

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