This study investigated the impact of Sanyrene liquid dressing (Urgo Medical, Cremorne, Australia), either alone or in combination with silicone foam dressing, on the skin microenvironment to provide an empirical foundation for the clinical application of these interventions. This study included 48 participants. Each participant’s right arm received a combination of Sanyrene liquid dressing and silicone foam dressing, while the left arm received Sanyrene liquid dressing alone. An additional intervention was conducted after 6 h. Skin temperature, moisture, and sebum content were measured and compared before intervention and at 1, 2, 3, and 4 h post-intervention. After the intervention, skin moisture and sebum on both sides significantly increased compared to pre-intervention levels (p<0.001). The right skin temperature post-intervention was significantly higher than that of pre-intervention (p=0.040); however, the left skin temperature did not differ significantly (p=0.584). No significant differences in skin temperature, moisture, and sebum were observed between the two arms post-intervention (p>0.05). Both intervention methods demonstrated the ability to supplement local skin moisture and sebum and can be safely reused after a certain interval. Although the use of foam dressings led to an increase in local skin temperature, the temperature elevation was deemed insufficient to risk additional damage.