The incidence of laryngeal cancer by anatomical site in south-western Finland

Grénman, Reidar; Pekkola‐Heino, Kirsi; Kinnala, Pekka

doi:10.1007/bf00178297

Cited by 7 publications

(4 citation statements)

References 5 publications

(3 reference statements)

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“…4,7,8,12,13,23 From an epidemiological perspective, male gender was significantly more dominant in the glottic than in the supraglottic LSCC patients. This finding is in concordance with other studies, 28,29 whereas in several studies gender was not related with tumor sublocalization. 30,31 Geographical differences in the use of alcohol between both sexes are known confounders.…”

Section: Discussionsupporting

confidence: 93%

Distinct Biomarker Profiles and Clinical Characteristics in T1‐T2 Glottic and Supraglottic Carcinomas

et al. 2020

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Background: In early stage laryngeal squamous cell carcinoma (LSCC) radiotherapy with curative intent is a major treatment modality. TNM classification is used to define patients eligible for radiotherapy. Studies in early stage glottic LSCC identified several predictive biomarkers associated with local control. However, we recently reported that this predictive value could not be confirmed in supraglottic LSCC. Objective: To examine whether clinical behavior and protein expression patterns of these biomarkers differ between glottic and supraglottic LSCC. Study Design: Retrospective cohort study. Methods: Tumor tissue sections of 196 glottic and 80 supraglottic T1-T2 LSCC treated primarily with RT were assessed immunohistochemically for expression of pAKT, Ki-67 and β-Catenin. Expression data of HIF-1α, CA-IX, OPN, FADD, pFADD, Cyclin D1, Cortactin and EGFR in the same cohort of glottic and supraglottic LSCC, were retrieved from previously reported data. The relationship between glottic and supraglottic sublocalization and clinicopathological, follow-up, and immunohistochemical staining characteristics were evaluated using logistic regression and Cox regression analyses. Results: Glottic LSCC were correlated with male gender (P = .001), hoarseness as a primary symptom (P < .001), T1 tumor stage (P < .001), negative lymph node status (P < .001), and an older age at presentation (P = .004). Supraglottic LSCC patients developed more post-treatment distant metastasis when adjusted for gender, age, and T-status. While supraglottic LSCC was associated with higher expression of HIF-1α (P = .001), Cortactin (P < .001), EGFR (P < .001), and Ki-67 (P = .027), glottic LSCC demonstrated higher expression of CA-IX (P = .005) and Cyclin D1 (P = .001). Conclusion: Differences in clinicopathological and immunohistochemical staining characteristics suggest that T1-T2 glottic and supraglottic LSCC should be considered as different entities.

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Section: Discussionsupporting

confidence: 93%

Distinct Biomarker Profiles and Clinical Characteristics in T1‐T2 Glottic and Supraglottic Carcinomas

et al. 2020

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“…The trend among women in our study was based on only a few cases and has to be viewed with caution. The same shift from supraglottic to glottic cancer has been found in two other reports concerning laryngeal cancer in men in Finland (17,18). It seems that the proportion of glottic cancer in the Finnish population in general has exceeded 50% and is approaching that of other western countries (3 -6).…”

Section: Discussionsupporting

confidence: 77%

Is the Subsite Distribution of Laryngeal Cancer Related to Smoking Habits?

Virtaniemi

Hirvikoski²,

Kumpulainen³

et al. 2000

Acta Oncologica

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In Finland traditionally as many as two-thirds of laryngeal cancers have been considered to be supraglottic, while in other countries the majority are glottic. The Finnish observation is based on clinical series diagnosed and treated mainly before the 1960s. The aim of our study was to evaluate the present situation. This study consisted of 279 patients treated in Eastern Finland between 1975 and 1994 and included 145 (52%) glottic, 124 (44%) supraglottic and 10 (4%) subglottic tumours in 260 (93%) men and 19 (7%) women. During this study period, the proportion of glottic tumours remained stable in men but increased in women. The change in smoking habits seems to be the most important reason for the shift from supraglottic to glottic tumours.

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“…A survey from the Turku University Central Hospital area in southwestern Finland, with a population of 700,000 [5], and one from the Tampere University Hospital area, with a population of 400,000 [10], both stated that the incidence of laryngeal tumors among males in the Finnish population was decreasing, and the different anatomical localizations were currently comparable to other parts of the Western world. The purpose of our present study was to re-evaluate the occurrence of laryngeal cancer in a nationwide survey by gender, with special reference to tumor localization inside the larynx.…”

Section: Introductionmentioning

confidence: 97%

Changing trends in the occurrence and subsite distribution of laryngeal cancer in Finland

Mäkitie

Pukander

Raitiola

et al. 1999

European Archives of Oto-Rhino-Laryngology

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Cancer of the larynx represents worldwide approximately 1-2% of all cancers and generally occurs predominantly in males. Based upon many reports, the age-adjusted incidence of laryngeal cancer has been rising in recent years, especially among women. Squamous cell carcinomas arising in the glottic region are the most common of all laryngeal cancers and more prevalent than the supraglottic ones. Subglottic disease is still rare. The Finnish Head and Neck Oncology Group evaluated the present occurrence of laryngeal cancer by site and gender in Finland. The annual age-standardized incidence of laryngeal cancer is 3.2 per 100,000 for men and 0.3 per 100,000 for women. The proportion of females in the five university centers reviewed was 5%. During the 30-year time period from the early 1960s to the 1990s there has been a significant decrease in the laryngeal cancer incidence rates for males, but no change for females. Finland thus seems to be the only Western country with clearly declining occurrence rates in recent decades. In the same time period a clear decrease in the incidence of bronchial cancer has occurred in males and an increase in females. The results also show that in all five university hospital districts glottic cancer became more common (50-68%) in the late 1980s and 1990s, which is opposite to the situation in the 1960s when supraglottic localizations (65%) dominated in Finland.

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The incidence of laryngeal cancer by anatomical site in south-western Finland

Cited by 7 publications

References 5 publications

Distinct Biomarker Profiles and Clinical Characteristics in T1‐T2 Glottic and Supraglottic Carcinomas

Distinct Biomarker Profiles and Clinical Characteristics in T1‐T2 Glottic and Supraglottic Carcinomas

Is the Subsite Distribution of Laryngeal Cancer Related to Smoking Habits?

Changing trends in the occurrence and subsite distribution of laryngeal cancer in Finland

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