The incidence of MRSA infections in the United States: is a more comprehensive tracking system needed?

Kavanagh, Kevin T.; Abusalem, Said; Calderon, Lindsay E.

doi:10.1186/s13756-017-0193-0

Cited by 43 publications

(39 citation statements)

References 9 publications

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“…Consequently, persons are exposed to illnesses caused by microbial. Nowadays, in infirmaries, the bacterial infections predominantly Gram‐positive bacteria (GPB) contagions remain the critical problem . Interestingly, majority of microbes are isolated from intensive care units, particularly, GPB isolation percentage is more than other bacteria .…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis of tri‐substituted pyrazole derivatives as promising antimicrobial agents and investigation of structure activity relationships

Reddy

Garcia

Yuvaraja

et al. 2020

Journal of Heterocyclic Chem

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The major diseases spread in the environment only because of microbes. Even, intensive care units in the hospitals are polluted by microorganisms, particularly, Gram-positive bacteria. Although many antibiotics are existed, there is a need to develop up to date microbial-resistant agents. Hence, the current study aimed to develop prominent antimicrobial drug-related compounds. Thus, a novel series of tri-substituted analogs and their intermediates were synthesized. In addition, total new compounds were screened for their antimicrobial assay and identified as the most efficient biologically active compounds. Moreover, minimal inhibitory antimicrobial activity and appropriate structure activity relationships were investigated. From the results it was observed that, viability of Gram-positive bacteria was most powerfully affected by all active compounds. Finally, this research demonstrated that, these biologically energetic amalgams can be utilized for further preclinical studies with the ambition of standing unique inventive drugs.

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Section: Introductionmentioning

confidence: 99%

Design, synthesis of tri‐substituted pyrazole derivatives as promising antimicrobial agents and investigation of structure activity relationships

Reddy

Garcia

Yuvaraja

et al. 2020

Journal of Heterocyclic Chem

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“…Hospital onset MSSA infection rates have remained at a steady rate since 2012, whereas community onset MSSA (CO-MSSA) infection rates continue to increase (1). Given U.S. Department of Health and Human Services' goal for a fty percent reduction of S. aureus invasive infections by 2020 (3,4), community based primary and secondary prevention efforts to prevent spread of these infections seem more than ever important to put in place. Majority of efforts have focused on reducing infections within healthcare settings, rather than in community settings.…”

Section: Introductionmentioning

confidence: 99%

Space Time Trends of Community Onset Staphylococcus Aureus Infections in Children Living in Southeastern United States: 2002-2010

Immergluck

Geng

et al. 2020

Preprint

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Background Staphylococcus aureus (S. aureus) remains a serious cause of infections in the U.S. and worldwide. Non antibiotic resistant Staphylococcus aureus (methicillin susceptible or MSSA) is the cause of half of all health care–associated staphylococcal infections, and methicillin resistant Staphylococcus aureus (MRSA) still is the leading cause of community onset skin and soft tissue infections in the U.S. This is the first study to spatially look at trends of both community onset MRSA and MSSA infections over nine years and determine ‘best’ to ‘worst’ infection trends over a nine year period (2002-2010),which spanned when community onset MRSA infections were occurring in epidemic proportions across the U.S. MethodsRetrospective study from 2002-2010, using electronic health records of children living in the southeastern U.S. (Atlanta, Georgia) with S. aureus infections and relevant U.S. census data (at the census tract level). The Proc Traj for SAS was applied to generate community onset MRSA and MSSA trajectory infection groups (low, high, very high, or deviant trends), and then, mapping of these trajectory groups using census tract boundaries.ResultsFrom community onset MRSA infection trend patterns (low, high, very high), only 0.8% of the census tracts showed a dramatic increase from 2002-2007 and then a gradual decline from 2008 to 2010. From community onset MSSA infection trend patterns (low and high), 85.7% of ‘high infection’ group persisted throughout the nine year period, compared to 14.3% of ‘low infection’ group over this same period. Low community onset MRSA and MSSA trend patterns were seen throughout the 20 counties of Atlanta, Georgia’s metropolitan statistical area, but more often seen in those counties less densley populated. Census tracts reflecting Atlanta’s ‘innercity’ had the highest proportion of the worst infection trend pattern (community onset MRSA-Very High-CO-MSSA-High or community onset MRSA-High-CO-MSSA-High). The deviant trend of community onset MRSA Very High- CO-MSSA Low infection were in census tracts east of downtown Atlanta. Conclusions ‘Trends’ of S. aureus infection patterns, stratified by antibiotic resistance, over geographic areas and time identify communities with higher risks for community onset MRSA infection compared to community onset MSSA infection.

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“…Due to its antibiotic resistance, MRSA can be quite lethal once the host is infected, although the mortality rate varies (13% to 21.8%) among studies. [7][8] The common symptoms of MRSA infection include fever and skin damage. [7] Though the well-known carrier of PBP2A, MRSA also contains β-lactamase to counter antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Amlodipine Inhibition and Antimicrobial Effects

Yi¹,

Zhu²,

Ma³

2019

IJPC

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Antibiotic resistant pathogens is the an urgent challenge of the medicine field. To counter these pathogens, the antibiotic assisting drugs is an ideal choice. Assisting drugs can improve the efficiency of the treatment without further induce of antibiotic resistance. Amlodipine (AML) is one of the most common generic cardiovascular drug for lowering blood pressure. In previous studies, amlodipine was suggested to have some antibiotic properties. The MIC is not very low for amlodipine against these pathogens. However, the findings imply amlodipine potential to be repurposed as assisting drug and its inhibition of β-lactamase. To further discover and verify its potential of antimicrobial drug, amlodipine was tested for β-lactamase inhibition, and its synergistic effects were investigated against methicillin-resistant Staphylococcus aureus (MRSA). The compound was found to inhibit β-lactamase mixture (3 distinct species) in broad spectrum. Cephalosporins requires high concentration (>=64 ug/ml) to inhibit MRSA; combine both amlodipine and cephalosporins, the MIC only requires 8ug/ml (4 ug/ml amlodipine + 4 ug/ml Cefuroxime) in total, with FIC lower than 0.1 for strong synergistic effect. Both enzyme assay and bacterial tests indicate amlodipine as an ideal assisting drug for antibiotics; one of the mechanism is β-lactamase inhibition.

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The incidence of MRSA infections in the United States: is a more comprehensive tracking system needed?

Cited by 43 publications

References 9 publications

Design, synthesis of tri‐substituted pyrazole derivatives as promising antimicrobial agents and investigation of structure activity relationships

Design, synthesis of tri‐substituted pyrazole derivatives as promising antimicrobial agents and investigation of structure activity relationships

Space Time Trends of Community Onset Staphylococcus Aureus Infections in Children Living in Southeastern United States: 2002-2010

Evaluation of Amlodipine Inhibition and Antimicrobial Effects

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