The incidence of myocardial infarction and stroke in head and neck cancer patients

Kwon, Hyun-Keun; Han, Kyungdo; Cheon, Yong-Il; Shin, Sung‐Chan; Lee, Minhyung; Sung, Eui‐Suk; Lee, Jin‐Choon; Lee, Byung‐Joo

doi:10.1038/s41598-021-83665-4

Cited by 13 publications

(30 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Out of 22 studies that reported the combined incidence of ischemic and hemorrhagic stroke at 1 year, eight were cohort studies that included multiple types of cancer ( Supplementary Figure 3 ) ( 12 , 14 , 15 , 25 , 27 , 31 , 33 , 34 ). The remaining 14 studies were limited to specific cancer subtypes including head and neck cancer ( n = 3) ( 16 , 24 , 28 ), hematologic malignancies ( n = 2) ( 19 , 29 ), breast cancer ( n = 2) ( 21 , 23 ), and thyroid cancer ( n = 2) ( 26 , 32 ). There was only one study for each of the following subtypes of cancer: pancreatic, cervical, prostate, colorectal, and hepatic ( 17 , 18 , 20 , 22 , 30 ).…”

Section: Resultsmentioning

confidence: 99%

“…Using the NOS risk of bias tool, we found that 6/41 studies were “poor quality,” one was “fair quality,” and the remaining 34 were “good quality” ( Supplementary Table 2 ). Subgroup analysis stratified by the ROB ratings found that 20 of 22 studies that reported 1-year stroke outcomes were deemed “good quality” ( 12 , 14 – 28 , 30 – 33 ), while one received a “poor” rating ( 34 ) and one received a “fair” rating ( 29 ). The studies that received a “good” rating had a similar pooled incidence of stroke at 1 year compared to the primary analysis ( Supplementary Figure 6 ): 1.4% (95% CI 0.9–2.2%, I 2 = 99.92%).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis

Lun

Deka

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

BackgroundPatients newly diagnosed with cancer represent a population at highest risk for stroke. The objective of this systematic review and meta-analysis was to estimate the incidence of stroke in the first year following a new diagnosis of cancer.MethodsWe searched MEDLINE and EMBASE from January 1980 to June 2021 for observational studies that enrolled adults with a new diagnosis of all cancers excluding non-melanoma skin cancer, and that reported the incidence of stroke at 1 year. PRISMA guidelines for meta-analyses were followed. Two reviewers independently extracted data and appraised risk of bias. We used the Dersimonian and Laird random effects method to pool cumulative incidences after logit transformation, and reported pooled proportions as percentages. Statistical heterogeneity was assessed using the I2 statistic.ResultsA total of 12,083 studies were screened; 41 studies were included for analysis. Data from 2,552,121 subjects with cancer were analyzed. The cumulative incidence of total stroke at 1 year was 1.4% (95% CI 0.9–2.2%), while the pooled incidence of ischemic stroke was 1.3% (95% CI 1.0–1.8%) and 0.3% (95% CI 0.1–0.9%) for spontaneous intracerebral hemorrhage (ICH), with consistently high statistical heterogeneity (>99% I2).ConclusionThe estimated incidence of stroke during the first year after a new diagnosis of cancer is 1.4%, with a higher risk for ischemic stroke than ICH. Cancer patients should be educated on the risk of stroke at the time of diagnosis. Future studies should evaluate optimal primary prevention strategies in this high-risk group of patients.Systematic review registrationhttps://osf.io/ucwy9/.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis

Lun

Deka

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Several studies have reported increased risks of CVD or stroke after the diagnosis of HNCA 9‐13 . Kwon et al 12 reported a 1.376‐fold higher incidence of myocardial infarction (MI) and 1.483‐fold higher incidence of stroke in the Korean population compared to the control group. In the Taiwanese population, the risk of stroke incidence was 1.44‐fold higher than that in the control cohort 13 .…”

Section: Discussionmentioning

confidence: 99%

“…15,16 In this report, CVD and stroke occurred in 6.4% and 5.2% of the HNCA population, respectively, rates similar to those reported previously. 12,13 Likewise, the risk factors associated with increased risk were male sex, older age, and related comorbidities, such as HTN or DM. [11][12][13] Among these related comorbidities, HTN, DM, and hyperlipidemia are also traditional risk factors for CVD or stroke.…”

Section: Discussionmentioning

confidence: 99%

The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea

Kang

Lee

Koo

et al. 2022

Health Science Reports

View full text Add to dashboard Cite

Background Head and neck cancer (HNCA) survivors have a high risk of developing cardiovascular disease (CVD) or stroke because of sharing risk factors of disease. Therefore, we investigated the risk of CVD or stroke occurrence among HNCA survivors in Korea based on the Health Insurance Review and Assessment (HIRA) Service claims database. Methods We retrieved claims data of patients who were diagnosed with HNCA in 2014‐2015 using ICD‐10 code and followed up data until 2018. Patients with newly diagnosed with CVD or stroke after HNCA diagnosis during the follow‐up period were detected. We analyzed the characteristics of patients with HNCA who were subsequently diagnosed with CVD or stroke. In addition, the risk factors of CVD or stroke occurrence were investigated using Cox proportional hazard regression analysis. Results Among the 8288 patients with HNCA, 477 and 404 patients were diagnosed with new‐onset CVD and stroke, respectively. Patients with hypertension, diabetes mellitus (DM), and hyperlipidemia had a 3.25‐fold higher risk of CVD comparing to patients without any underlying disease (95% confidence index [CI], 2.38‐4.45) Patients with three underlying diseases had a 2.92‐fold higher risk of stroke compared to patients without any underlying disease (95% CI 2.03‐4.21). Conclusions HNCA survivors with hypertension, DM, and hyperlipidemia should be cautious of the risks of CVD and stroke.

show abstract

“…The risk of CVD was reported to be inconsistent among cancers [ 4 , 5 ]. However, previous retrospective cohort studies have shown conflicting results: patients with cancer had a higher [ 6 ] or lower [ 7 ] risk of CVD than patients without cancers, men had a higher [ 6 ] or similar [ 8 ] risk as that of women, younger cancer patients had a higher [ 9 ] or lower [ 6 ] risk of CVD than the elderly, and the risk of CVD decreased [ 10 ] or increased [ 11 ] gradually after the diagnosis of cancer.…”

Section: Introductionmentioning

confidence: 99%

Risk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in Taiwan

Yeh

Hsu

et al. 2022

BMC Cancer

View full text Add to dashboard Cite

Background The associations with cancer and cardiovascular diseases (CVD) had inconsistent results. The study aimed to investigate the risk of cardiovascular diseases (CVD) between populations with and without cancer. Methods Patients with common cancers in Taiwan were enrolled in the study between 2007 and 2018 using the Taiwan Cancer Registry. We focused on colorectal cancer, women’s breast cancer, lung cancer, liver cancer, oral cancer, prostate cancer, and thyroid cancers. The study endpoint was fatal and non-fatal CVD, which was defined as ischemic heart disease and ischemic stroke according to the National Health Insurance Research Database. We compared the risk of CVD between patients with cancer and age- and sex-matched (1:1 ratio) participants who did not have cancer or CVD. Multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were obtained from Cox regression analysis. To evaluate the chronological trend, we estimated the HRs and 95% CI yearly since the diagnosis. Results Among the 552,485 cancer patients (mean age, 60.6 years; women, 47.7%) during the median follow-up period of 4.1 years, 32,634 cases of fatal and non-fatal CVD were identified. Compared with that noted in the non-cancer population, the overall fully adjusted HR with 95% CI was 1.28 (1.25, 1.30) in the cancer population. The CVD risk was the highest in the first year, the adjusted HR with 95% CI was 2.31 (2.23, 2.40), and this risk decreased yearly. Conclusions Patients with cancer had a significantly higher risk of fatal or non-fatal CVD. The risk was the highest in the first year since diagnosis and decreased yearly.

show abstract

The incidence of myocardial infarction and stroke in head and neck cancer patients

Cited by 13 publications

References 45 publications

Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis

Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis

The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea

Risk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in Taiwan

Contact Info

Product

Resources

About