The Incidence of Necrotizing Changes in Adults With Pneumococcal Pneumonia

Pande, Anupam; Nasir, Saifullah; Rueda, Adriana M.; Matejowsky, Rebecca; Ramos, Juan Manuel Lebrón; Doshi, Simit; Kulkarni, Prathit A.; Musher, Daniel M.

doi:10.1093/cid/cir749

Cited by 40 publications

(48 citation statements)

References 32 publications

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“…Streptococcus pneumoniae was found in three patients (2.12%) [1]. Necrotizing pneumonia has generally been regarded as a rare complication of pneumococcal infection in adults [2,3]. Serotype 3 of Streptococcus pneumoniae was the single most common type implicated in necrosis; however, many other serotypes were implicated [2].…”

Section: Introductionmentioning

confidence: 99%

“…Necrotizing pneumonia has generally been regarded as a rare complication of pneumococcal infection in adults [2,3]. Serotype 3 of Streptococcus pneumoniae was the single most common type implicated in necrosis; however, many other serotypes were implicated [2]. This entity predominately infects children, but is present also in adults (Table 1) [2].…”

Section: Introductionmentioning

confidence: 99%

“…Serotype 3 of Streptococcus pneumoniae was the single most common type implicated in necrosis; however, many other serotypes were implicated [2]. This entity predominately infects children, but is present also in adults (Table 1) [2]. In the USA and in Taiwan, infection with Streptococcus pneumoniae serotype 3 (mainly ST180) was a significant contributor to necrotizing pneumonia and lung abscess [3].…”

Section: Introductionmentioning

confidence: 99%

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Lung Abscess Due to Streptococcus pneumoniae: A Case Series and Brief Review of the Literature

Nicolini¹,

Cillóniz

Senarega³

et al. 2014

Advances in Respiratory Medicine

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Anaerobes used to be the most common cause of community-acquired lung abscess, and Streptococcus species used to be the second most common cause. In recent years, this has been changing. Klebsiella pneumoniae is now an increasing cause of community-acquired lung abscess, but Streptococcus species continue to be major pathogens. Necrotizing pneumonia has generally been regarded as a rare complication of pneumococcal infection in adults. Type 3 Streptococcus pneumoniae was the single most common type implicated in necrosis; however, many other serotypes were implicated. This entity predominately infects children, but is present also in adults. Lung abscess in adults due to Streptococcus pneumoniae is not common. In this regard we present a case series of pulmonary cavitation due to Streptococcus pneumoniae and discuss the possible pathogenic mechanism of the disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lung Abscess Due to Streptococcus pneumoniae: A Case Series and Brief Review of the Literature

Nicolini¹,

Cillóniz

Senarega³

et al. 2014

Advances in Respiratory Medicine

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“…During the last decade, diagnosis of pneumonia by chest CT has become more common, given the increasing numbers of CT scans performed to rule out other diseases such as pulmonary embolism (21). In this study, the occurrence of necrotizing pneumonia was as high as 65.5% when cases were diagnosed using chest CT (22).…”

Section: Discussionmentioning

confidence: 70%

Implementation of chest ultrasound with color Doppler in diagnosis of pneumonia in adults

Kader

Osman

2016

The Egyptian Journal of Radiology and Nuclear Medicine

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Objective: To evaluate the role of color Doppler sonography in comparison with CXR and CT imaging in diagnosis of pneumonia in adults. Patients and methods: Thirty-one patients with clinical suspicion of pneumonia were assessed by chest radiography, CT and sonography. Quantitative and qualitative sonographic examination of lesions was performed using color Doppler imaging. The correlation between color Doppler and CT findings was determined. Results: Lung ultrasound showed high sensitivity (100%), specificity (93.8%) and diagnostic accuracy 96.8% in diagnosis of pneumonia. It detected air bronchogram in all cases, simple effusion in 18 cases and effusion with internal echoes in 8 cases. It was almost agreement with CT findings (K = 0.93). The sensitivity of chest X-ray was low (60%). It was moderate agreement with CT findings (K = 0.608). A significant changes were seen in flow pattern in comparison with severity of necrosis by CT (P value = 0.038). Majority of our cases reflected pulmonary arterial flow pattern that was found in 21 cases. Conclusion: Lung ultrasound with color Doppler imaging is highly accurate and valid alternatively in diagnosis of pneumonia. By qualitative and quantitative impedance measurement, pulmonary and bronchial arteries can be differentiated. The flow pattern of pulmonary arteries was an indicative of good outcome.

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“…Mellkasi empyema az összes pneumoniás eset 5-12%-ában lép fel [34]. Viszonylag ritka szövődmény a tüdőabscessus és a nekrotizáló pneumonia: egy nemrég publikált retrospektív vizsgálat szerint az összes S. pneumoniae-pneumonia 6,6%-ában láttak tüdőnecrosisnak megfelelő radiológiai jeleket [35]. A pneumonia követ-kezménye gépi lélegeztetést igénylő akut légzési elégte-lenség kifejlődése is lehet.…”

Section: Szövődménnyel Gyógyuló Pneumococcuspneumoniaunclassified

A Streptococcus pneumoniae (pneumococcus) -infekciók ezer arca

et al. 2015

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A Streptococcus pneumoniae (pneumococcus) által okozott infekciók világszerte, így Magyarországon is, tartósan magas morbiditási és mortalitási mutatókkal rendelkeznek a gyermek-és felnőttpopulációban egyaránt. A felnőttkori, hospitalizációt igénylő, otthon szerzett tüdőgyulladások 35-40%-ában a pneumococcus kóroki szerepe igazolható, az S. pneumoniae-pneumoniák 25-30%-a bacteraemiával jár. Az összes fertőzés 5-7%-a fatális kimenetelű, idősek és rizikóbetegek körében az arány meredeken növekedik. A súlyos, invazív formában zajló infekciók esetében a mortalitás elérheti a 20%-ot, a szövődményráta adekvát antibiotikus terápia mellett is jelentős. A szerzők összefoglalják a pneumococcalis betegségek epidemiológiáját, a noninvazív és invazív fertőzések patogenezisét, valamint prezentálják a legfontosabb klinikai aspektusokat esetbemutatásokon keresztül. A betegek rizikóstratifi kációja, a hemokultúrák vétele és a korai antibiotikum-kezelés mellett az aktív immunizáció széles körű alkalmazása segíthet csökkenteni az invazív fertőzések mortalitását. A pneumococcus elleni vakcináció javasolt minden 50 év feletti felnőttnek, illetve minden 18 év feletti krónikus betegnek, aki alapbetegsége miatt fogékony a pneumococcalis infekcióra. Orv. Hetil., 2015, 156(44), 1769-1777. Kulcsszavak: pneumococcus, Streptococcus pneumoniae, invazív pneumococcusbetegség, IPD, konjugált vakcina, poliszacharidvakcina Thousand faces of Streptococcus pneumoniae (pneumococcus) infectionsIncidence and mortality rates of infections caused by Streptococcus pneumoniae (pneumococcus) are high worldwide and in Hungary among paediatric as well as adult populations. Pneumococci account for 35-40% of community acquired adult pneumonias requiring hospitalization, while 25-30% of Streptococcus pneumoniae pneumonias are accompanied by bacteraemia. 5-7% of all infections are fatal but this rate is exponentially higher in high risk patients and elderly people. Mortality could reach 20% among patients with severe invasive pneumococcal infections. Complications may develop despite administration of adequate antibiotics. The authors summarize the epidemiology of pneumococcal infections, pathogenesis of non-invasive and invasive disease and present basic clinical aspects through demonstration of four cases. Early risk stratifi cation, sampling of hemocultures, administration of antibiotics and wider application of active immunization could reduce the mortality of invasive disease. Anti-pneumococcal vaccination is advisable for adults of ≥50 years and high risk patients of ≥18 years who are susceptible to pneumococcal disease.

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The Incidence of Necrotizing Changes in Adults With Pneumococcal Pneumonia

Cited by 40 publications

References 32 publications

Lung Abscess Due to Streptococcus pneumoniae: A Case Series and Brief Review of the Literature

Lung Abscess Due to Streptococcus pneumoniae: A Case Series and Brief Review of the Literature

Implementation of chest ultrasound with color Doppler in diagnosis of pneumonia in adults

A Streptococcus pneumoniae (pneumococcus) -infekciók ezer arca

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