The incidence of new onset diabetes after transplantation and related factors: Single center experience

Sinangil, Ayşe; Çelik, Vedat; Barlas, Soykan; Koç, Yener; Baştürk, Taner; Şakacı, Tamer; Akın, Emin Barış; Ecder, Tevfik

doi:10.1016/j.nefroe.2017.02.008

Cited by 9 publications

(21 citation statements)

References 49 publications

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“…ese values evidence a pretransplant insulin resistance, similar to findings reported by Gomes et al recently [25]. International Journal of Endocrinology With respect to pretransplant hypertriglyceridemia, its role as a marker for insulin resistance has been clearly studied, and in multivariable analysis of some retrospective cohorts, it has been associated with NODAT [26]. Porrini et al in its cohort study showed that pretransplant triglyceride levels >200 mg/dl increase the risk of presenting this disease in patients who received treatment with tacrolimus (OR 3.26, 95% CI 1.4-7.8, p � 0.002), while this was not observed in those who received treatment with cyclosporine [27].…”

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confidence: 86%

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Risk Factors Related to New-Onset Diabetes after Renal Transplantation in Patients of a High Complexity University Hospital in Colombia, 20 Years of Experience

Guzmán

Victoria

Ramos

et al. 2020

International Journal of Endocrinology

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Introduction. New-onset diabetes after transplantation (NODAT) is associated with immunosuppression. Its complications can negatively influence patients’ quality of life, which is why it is important to study the associated risk factors and expand the possible therapies in this particular group of patients. Materials and methods. Case-control study nested in a retrospective cohort. It included patients who received kidney transplantation at the high complexity University Hospital Fundación Valle del Lili in Cali, Colombia, between 1995 and 2014. Two controls were assigned for each case, depending on the type of donor and the date of the surgery. Information was collected from clinical records and the institutional TRENAL registry. We carried out a descriptive analysis of the selected variables and identified the risk factors with conditional logistic regression. Results. 122 cases were identified to which 224 controls were assigned. The median age was 44 years (IQR: 34–55), and 54% were men. Having >50 years of age at the time of transplantation (OR: 3.18, 95% CI: 1.6−6.3, p = 0.001), body mass index >30 kg/m2 (OR: 3.6, 95% CI: 1.3−9.7, p = 0.010) and being afro-descendant (OR: 2.74, 95% CI: 1.1−6.5, p = 0.023) were identified as risk factors for the development of NODAT. Pretransplant fasting plasma glucose >100 mg/dl (OR: 2.9, 95% CI: 1.4−6.4, p = 0.005) and serum triglycerides >200 mg/dl (OR: 2.5, 95% CI: 1.4−4.4, p = 0.002) were also reported as independent risk factors. Conclusion. We ratify some risk factors for the development of this important disease, which include certain modifiable characteristics. Interventions aimed at changes in lifestyle could be established in a timely manner before transplant surgery.

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confidence: 86%

“…is particular factor was significant in our bivariable analysis (OR 2.15, 95% CI 1.3-3.6, p � 0.003), but after multivariable analysis, its statistical significance was lost. is same phenomenon occurred in the retrospective study carried out by Sinangil et al [26].…”

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confidence: 80%

Risk Factors Related to New-Onset Diabetes after Renal Transplantation in Patients of a High Complexity University Hospital in Colombia, 20 Years of Experience

Guzmán

Victoria

Ramos

et al. 2020

International Journal of Endocrinology

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“…NODAT can lead to related complications, such as kidney transplant failure, cardiovascular disease and infection 4 , seriously endangering the quality of life and prognosis of patients with a kidney transplant, and increasing their economic burden. Some studies have shown that the occurrence and development of NODAT after renal transplantation are affected by age, body mass index (BMI), hepatitis C virus (HCV) infection, cytomegalovirus (CMV) infection, use of immunosuppressive drugs, polycystic kidney disease, acute rejection, family history of diabetes mellitus and other risk factors [5][6][7][8][9][10][11] ; however, there are still controversies. Therefore, a comprehensive and accurate understanding of NODAT-related risk factors after renal transplantation is necessary to prevent and clinically manage NODAT in renal transplant recipients.…”

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confidence: 99%

Risk factors for new‐onset diabetes mellitus after kidney transplantation: A systematic review and meta‐analysis

Xia

Yang

Tong

et al. 2020

J of Diabetes Invest

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Aims/Introduction: To systematically review the risk factors for new-onset diabetes mellitus after kidney transplantation, and to provide a theoretical basis for the prevention and management of new-onset diabetes mellitus after kidney transplantation. Materials and Methods: We searched PubMed, Web of Science, Embase, the Cochrane Library databases and other databases for case-control studies related to risk factors for newonset diabetes mellitus after kidney transplantation published between January 2005 and July 2019. A meta-analysis of data on risk factors for new-onset diabetes mellitus after kidney transplantation from the included studies was carried out. A narrative review of risk factors for new-onset diabetes mellitus after kidney transplantation was also carried out. Results: A total of 24 case-control studies were included in the meta-analysis, with a total of 7,140 patients. There were 1,598 patients with new-onset diabetes mellitus after kidney transplantation, and 5,542 patients without new-onset diabetes mellitus after kidney transplantation. The meta-analysis results showed that age, polycystic kidney disease, family history of diabetes, body mass index, acute rejection, tacrolimus use, hepatitis B virus infection, hepatitis C virus infection and hypertension were associated with new-onset diabetes mellitus after kidney transplantation, whereas sex, sirolimus use, cyclosporin A use, steroid use and cytomegalovirus infection were not associated with new-onset diabetes mellitus after kidney transplantation. Conclusions: Older age, body mass index, family history of diabetes, tacrolimus use, history of hypertension, polycystic kidney disease, acute rejection, hepatitis B virus infection and hepatitis C virus infection are risk factors for new-onset diabetes mellitus after kidney transplantation. Therefore, the clinical implications of these factors warrant attention.

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“…Já no estudo de Maes e colaboradores (2001) um nível acima de 15ng/ml durante o primeiro mês após o transplante esteve associado com o desenvolvimento de DMPT. No estudo de Sinangil (2017) quase 81% dos pacientes com DMPT apresentaram valores iniciais acima de 20ng/ml nesse mesmo período (SINANGIL, 2017). A redução progressiva dos níveis de FK está relacionado a uma menor incidência de DMPT, sendo que muitos estudos correlacionam uma dosagem abaixo de 10ng/ml com melhora na sobrevida do enxerto e risco reduzido para DMPT (RODRIGO et.…”

Section: Discussionunclassified

“…A redução progressiva dos níveis de FK está relacionado a uma menor incidência de DMPT, sendo que muitos estudos correlacionam uma dosagem abaixo de 10ng/ml com melhora na sobrevida do enxerto e risco reduzido para DMPT (RODRIGO et. al, 2006;SINANGIL, 2017). Em nosso estudo observamos valores acima de 10ng/ml apenas nos pacientes do grupo DMPT na primeira avaliação (com queda nos demais tempos), e os demais pacientes mantiveram valores inferiores durante todo estudo; entretanto não foi possível correlacionar o desenvolvimento de DMPT com as dosagens de FK.…”

Section: Discussionunclassified

Avaliação de mudanças em estado nutricional e composição corporal no desenvolvimento de diabetes mellitus após o transplante renal

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The incidence of new onset diabetes after transplantation and related factors: Single center experience

Cited by 9 publications

References 49 publications

Risk Factors Related to New-Onset Diabetes after Renal Transplantation in Patients of a High Complexity University Hospital in Colombia, 20 Years of Experience

Risk Factors Related to New-Onset Diabetes after Renal Transplantation in Patients of a High Complexity University Hospital in Colombia, 20 Years of Experience

Risk factors for new‐onset diabetes mellitus after kidney transplantation: A systematic review and meta‐analysis

Avaliação de mudanças em estado nutricional e composição corporal no desenvolvimento de diabetes mellitus após o transplante renal

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