The incidence of oral clefts: a review

A, Derijcke; Eerens, A; Carels, Carine

doi:10.1016/s0266-4356(96)90242-9

Cited by 201 publications

(138 citation statements)

References 15 publications

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“…6 In European countries, the prevalence rate varies from 1.3 to 1.81 per 1,000 born. 7 In general, epidemiological information related to cleft lip and palate in children groups is not available due to reduced samples and the risks of irregularity in notifi cation, when clefts are not registered immediately after birth. 8 The etiologic factors are related to genetic interaction and environmental factors (infectious agents, ionizing radiation, licit or illicit drugs, hormones and nutritional defi ciencies), 9,10 which are responsible for 70 to 80% of all cases.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of orofacial clefts and social factors in Brazil

et al. 2009

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The aim of this study was to investigate the prevalence of orofacial clefts in live newborns from 1998 to 2002 in Brazilian state capitals and correlate their occurrence with a number of relevant socioeconomic factors collected in the 2000 census. Data was obtained from the Public Health Hospital Information System (SIH-SUS), Information System of Live Hospital Births (SINASC) and Atlases of Human Development in Brazil. The results showed that the mean prevalence of orofacial clefts in Brazil was 0.36 per 1,000 live births. Using Pearson's correlation coeffi cient, the correlation between cleft rate and social factors was not statistically signifi cant (p > 0.05). Our study suggests that there is no correlation between the municipal economic factors and the prevalence of orofacial clefts, which is likely infl uenced by underrecording problems in the less developed municipalities.

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Section: Introductionmentioning

confidence: 99%

Prevalence of orofacial clefts and social factors in Brazil

et al. 2009

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“…Regarding the type of cleft, a number of authors have observed that cleft lip and palate is more frequent than the isolated cleft lip and isolated cleft palate [3][4][5][6][7][8]10,12,16,17,19 . Nevertheless, there were also scarce findings of higher frequencies of RESUMO: Foi objetivo do presente estudo investigar a distribuição atual dos vários tipos de fissuras entre pacientes que compareceram ao Hospital de Reabilitação de Anomalias Craniofaciais (HRAC-USP), Bauru, Brasil, pela primeira vez, no ano de 2000.…”

Section: Introductionunclassified

“…Most studies have indicated higher rates of unilateral clefts compared to bilateral, as the left side is the most commonly affected by clefting [2][3][4][5][6][7]9,[14][15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

“…In relation to the association between clefting and gender, a worldwide trend has been observed towards higher rates of isolated cleft palate among females and higher frequencies of cleft lip with or without cleft palate in males [2][3][4][5][6][7]10,12,[14][15][16][17][18] . Some authors have also made an attempt to observe a possible relationship between race and type of cleft.…”

Section: Introductionmentioning

confidence: 99%

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Current data on the characterization of oral clefts in Brazil

et al. 2004

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ABSTRACT:This study aimed at investigating the current distribution of the several types of clefts among the patients receiving treatment at the Hospital for Rehabilitation of Craniofacial Anomalies (HRAC-USP), Bauru, Brazil, for the first time during the year 2000. A total of 803 unoperated patients with cleft lip and/or palate, with or without additional malformations, with no recognizable syndromes, who came to the HRAC-USP for enrollment for treatment during the year 2000. A predominance of complete cleft lip and palate, either unilateral or bilateral, was observed (37.1%), followed by isolated cleft palate (31.7%) and isolated cleft lip (28.4%). A discrete relationship between cleft palate and the female gender was noticed (53%), and males were more affected by the other types of clefts (around 60%). The findings revealed a predominance of complete clefts of the primary and secondary palate, the treatment of which is more complex, and whose frequency is greater in males.

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“…3 In Asians, the prevalence rate of non-syndromic cleft lip with or without cleft palate has been reported as 1.19 per 1000 live births. 4 Fetal lip development is completed at B5 to 6 weeks of gestational age, and the palate will close B10 weeks after gestation.…”

Section: Introductionmentioning

confidence: 99%

Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations

et al. 2013

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ATP-binding cassette (ABC) proteins in the placenta regulate fetal exposure to xenobiotics. We hypothesized that functional polymorphisms in ABC genes influence risk for non-syndromic oral clefts (NSOC). Both family-based and case-control studies were undertaken to evaluate the association of nine potentially functional single-nucleotide polymorphisms within four ABC genes with risk of NSOC. Peripheral blood DNA from a total of 150 NSOC case-parent trios from Singapore and Taiwan were genotyped, as was cord blood DNA from 189 normal Chinese neonates used as controls. In trios, significant association was observed between the ABCB1 single-nucleotide polymorphisms and NSOC (Po0.05). Only ABCB1 rs1128503 retained significant association after Bonferroni correction (odds ratio (OR) ¼ 2.04; 95% confidence interval (CI) ¼ 1.42-2.98), while rs2032582 and rs1045642 showed nominal significance. Association with rs1128503 was replicated in a case-control analysis comparing NSOC probands with controls (OR ¼ 1.58; 95% CI ¼ 1.12-2.23). A comparison between the mothers of probands and controls showed no evidence of association, suggesting NSOC risk is determined by fetal and not maternal ABCB1 genotype. The two studies produced a combined OR of 1.79 (95% CI ¼ 1.38-2.30). The T-allele at rs1128503 was associated with higher risk. This study thus provides evidence that potentially functional polymorphisms in fetal ABCB1 modulate risk for NSOC, presumably through suboptimal exclusion of xenobiotics at the fetal-maternal interface.

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The incidence of oral clefts: a review

Cited by 201 publications

References 15 publications

Prevalence of orofacial clefts and social factors in Brazil

Prevalence of orofacial clefts and social factors in Brazil

Current data on the characterization of oral clefts in Brazil

Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations

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