The Incidence of Premalignant and Malignant Disease in Reinke's Edema

Lim, Shueh Y.; Sau, Phoebe C.Y.; Cooper, Lorna; McPhaden, Allan R.; MacKenzie, Kenneth J.D.

doi:10.1177/0194599813495815a154

Cited by 7 publications

(11 citation statements)

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“…In contrast, keratosis on RPNC lesions was associated with benign histopathology. This confirmed previous findings of primarily benign pathology in tobacco‐induced polypoid corditis . Overall laryngeal keratosis did not predict histopathology, as previous studies had demonstrated that nearly half of laryngeal keratosis is due to benign etiology .…”

Section: Discussionsupporting

confidence: 88%

Correlating laryngoscopic appearance of laryngeal lesions with histopathology

Anis

2018

The Laryngoscope

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Objectives/Hypothesis Meticulous scrutiny of laryngeal lesions with laryngoscopes and microscopes often identify angiogenic activity, one of the hallmarks of neoplastic and preneoplastic lesions. The aim of this study was to determine if there is an association between laryngoscopic appearance and histopathology of laryngeal lesions based on operative biopsies. Study Design Retrospective case‐control study. Methods One hundred forty‐four laryngeal biopsies from 92 patients between 2015 and 2017 met inclusion criteria. Cases were patients who had biopsy‐proven laryngeal dysplasia or malignancy. Controls were patients who had benign laryngeal pathology. All of the laryngeal lesions had either keratosis or vascular stippling, an indication of angiogenic activity. Medical records, videostroboscopies and operative findings of these patients were reviewed. Multivariable logistic regression was used to examine the correlation between laryngoscopic appearance of laryngeal lesions and presence or absence of dysplasia and invasive carcinoma. Results Fifty percent of the 144 laryngeal lesions were classified either as dysplastic or malignant by histopathology. Vascular stippling was present in 31% of all laryngeal lesions. On logistic regression, vascular stippling was significantly associated with dysplastic and malignant lesions (P = .0018). Overall sensitivity and specificity of vascular stippling and the presence of dysplasia and malignancy were 51% and 89%, respectively. Conclusions Laryngoscopic and microscopic appearance of vascular stippling could inform clinicians on diagnostic sampling of suspicious laryngeal lesions that reduces delay in diagnosis. The low sensitivity of vascular stippling underlies the importance of maintaining high clinical suspicion and proceeding to the operating theater for adequate tissue sampling. Level of Evidence 3 Laryngoscope, 129:1308–1312, 2019

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Section: Discussionsupporting

confidence: 88%

Correlating laryngoscopic appearance of laryngeal lesions with histopathology

Anis

2018

The Laryngoscope

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“…RE has been strongly related to smoking as one of its etiologic factors in which the amount and duration of exposure are influential. 40 We did not find a difference in HA concentration as a function of smoking load ( Table 2 ). All of the patients were smokers with high smoking loads, varying from 10 to 80 pack-years and thus exposed to chronic aggravation.…”

Section: Discussionmentioning

confidence: 60%

Hyaluronic Acid Concentration in Female Vocal Folds With Reinke’s Edema

Lins¹,

Martins

Kobayashi

et al. 2021

Otolaryngol.--head neck surg.

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Objective The aim of the present study was to investigate hyaluronic acid (HA) concentrations in vocal folds among patients with Reinke’s edema. Study Design Prospective and experimental study. Setting Single tertiary center. Methods An HA binding protein isolated from bovine nasal cartilage was used to identify and isolate the HA from samples. Plates coated with biotin-conjugated binding protein and streptavidin-europium conjugate were sequentially incubated with 18 Reinke’s edema samples and 11 female vocal fold cover samples from cadavers (the superficial layer of the lamina propria; control group). After the release of europium from streptavidin in enhancement solution, final fluorescence was measured in a fluorometer. Results The mean HA concentration in Reinke’s edema vocal folds was significantly higher than that in the control vocal folds (9.2 × 103 vs 0.9 × 103µg/g). Conclusion Vocal fold covers affected by Reinke’s edema present a higher concentration of HA than do vocal fold covers with no edema.

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“…16 The range and proportion of dysplasia severity on histopathology in this cohort was in accordance with prior studies. 11,12,14 Fifty-nine of 95 (62%) lesions were categorized as RE grades 3 and 4. Only 3 (3%) of the lesions were grade 1.…”

Section: Discussionmentioning

confidence: 99%

“…Prior studies have shown the incidence of severe dysplasia in RE to be between 0% and 3%. 3,[11][12][13][14] Alternatively, the incidence of no dysplasia at all ranges from 11% to 100%. 12,14 The overwhelming majority of lesions are seen to have no malignant potential.…”

Section: Introductionmentioning

confidence: 99%