“…In a retrospective cohort study, the metastasis incident is found to be 1.2% for women (6 incident in 553 patients) who had scalp cooling method and 1.1% for women (1 incident in 87 patients) who didn't have cold application treatment (41). In a meta-analysis, scalp metastasis incident is found 0.56% (12 in 2129 patients) (42). In addition all these, scalp cooling method is contraindicated in cases of, hematological malignancies (leukemia, multiple myeloma, non-Hodgkins and other generalized lymphomas), cold sensitivity, cold agglutinin disease, cryoglobulinemia, cryofibrinogenemia, cold traumatic dystrophy, melanoma patients with adjuvant or curative chemotherapy (43).…”