The incidence of schistosomiasis in South Central Africa

Gelfand, M; Ross, W. Fraser

doi:10.1016/0035-9203(49)90065-6

Cited by 8 publications

(3 citation statements)

References 4 publications

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“…Davies and Wilson (1954) noted a low incidence of schistosomiasis in Kampala but the age distribution of cancer of the bladder was higher than that recorded in the Gold Coast. Gelfand (1950) did not consider that bilharzial disease was a cause of bladder cancer in South Central Africa, the autopsy incidence in the Bantu being 0-25 per cent, a similar figure to the incidence in autopsies in the Gold Coast. In the Gold Coast however the age distribution of the autopsy material must be considered and these figures cannot be compared with records from Europe owing to the small number of autopsies in the older age groups.…”

Section: Carcinoma Of the Ovarymentioning

confidence: 96%

Malignant Disease in the Gold Coast

Edington¹

1956

Br J Cancer

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Section: Carcinoma Of the Ovarymentioning

confidence: 96%

Malignant Disease in the Gold Coast

Edington¹

1956

Br J Cancer

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“…Although the prevalence of central nervous system (CNS) invasion in schistosomal infection has been considered to be low (20), CNS involvement in S. haematobium infection may be underdiagnosed. An autopsy study in Africa showed that over half of patients infected with S. haematobium in the bladder had brain lesions (8). Another pathological study in Africa has found scattered ova of S. haematobium or S. mansoni in the brain at autopsy in over a quarter of 150 unselected cadavers (1).…”

Section: Case Reportmentioning

confidence: 99%

Cerebral Schistosomiasis Due to Schistosoma haematobium Confirmed by PCR Analysis of Brain Specimen

et al. 2011

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The case of a 25-year-old Japanese male who had cerebral schistosomiasis caused by Schistosoma haematobium is reported here. Although serum antibody tests showed a cross-reaction with other helminths and no ova were excreted in urine or feces, the existence of Schistosoma haematobium in the brain was confirmed by PCR analysis. CASE REPORTIn October 2009, a 25-year-old Japanese man was admitted to a local community hospital in Japan with a 1-week history of mild headache and sporadic paraphasia. He had worked as an agricultural consultant in the Republic of Malawi from April 2007 to June 2009. During his stay, he lived with local residents, consumed water from a well, and had swum in a lake at least twice. He had been in excellent health until October 2009, except for a Giardia lamblia infection in 2008. At the community hospital, a computed tomography (CT) scan of the patient's head showed four hyperdense and edematous lesions in the left parietal lobe, and these lesions were suspected to be related to tropical infectious diseases due to the fact that the onset of his symptoms appeared soon after his return from the Republic of Malawi. Subsequently, the patient was referred to our institution for further workup.Upon presentation to our institute, the patient's temperature was 36.8°C, his pulse was 60 beats per minute (bpm), and his blood pressure was 120/70 mm Hg. Although the patient was alert and appropriate at a glance, verbal paraphasia was occasionally observed. Laboratory evaluation revealed the following: white blood cell count, 8,780/l (67.5% neutrophils, 25.0% lymphocytes, 1.5% eosinophils); serum C-reactive protein, 0.03 mg/dl; IgE, 18 U/ml; HIV antibody negative; toxoplasma IgM and IgG negative; and Entamoeba antibody negative. A magnetic resonance imaging (MRI) scan of the brain with gadolinium enhancement showed a couple of ill-defined, heterogeneously enhancing lesions. They were each approximately 10 mm in diameter, in the left parietal lobe, with increased intensity of the signal on the T1-weighted image (Fig. 1). A lumbar puncture was not performed. The patient's headache and nausea worsened rapidly, and we were obliged to relieve his symptoms as soon as possible. Based on the clinical presentation and characteristic imaging finding, we clinically concluded that the cerebral lesions were neurocysticercosis. Albendazole (15 mg/kg of body weight per day) was administered with dexamethasone (0.1 mg/kg per day) for a total of 8 days. The patient's headache and nausea then subsided, and the verbal paraphasia disappeared. The findings from an MRI scan of the brain were improved but still remained.One week after the initiation of treatment, the results of the commercially available serum enzyme-linked immunosorbent assay (ELISA; SRL, Tokyo, Japan), which can detect IgG antibody for 12 helminthic diseases as a screening (22), were reported: Spirometra erinacei (also known as Spirometra mansoni) antibody on admission was positive, whereas Taenia solium antibody was negative. Schistosoma species are not ...

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“…Rarely the appendix and the caecum are affected and, even more rarely, the ileum as well. Manson-Bahr (1960), Gelfand (1950, and Saleh (1962), in postmortem studies, found the small intestine to be affected in 3%. Saleh (1962) also found the pancreas to be affected in 12%.…”

Section: Medical Memoranda Malabsorption and Schistosomal Involvementmentioning

confidence: 99%

Malabsorption and schistosomal involvement of jejunum.

Sherif¹

1970

BMJ

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The incidence of schistosomiasis in South Central Africa

Cited by 8 publications

References 4 publications

Malignant Disease in the Gold Coast

Malignant Disease in the Gold Coast

Cerebral Schistosomiasis Due to Schistosoma haematobium Confirmed by PCR Analysis of Brain Specimen

Malabsorption and schistosomal involvement of jejunum.

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