2011
DOI: 10.1097/bpo.0b013e31822889c9
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The Incidence of Spondylolysis and Spondylolisthesis in Children With Osteogenesis Imperfecta

Abstract: This study found that the incidence of spondylolysis in a group of children with OI was much higher than in the normal pediatric population, which has been reported to be 2.6% to 4.0%. This incidence was also found to be higher than previously reported incidence of spondylolysis in OI patients (5.3%). The incidence of spondylolisthesis was also found to be much higher than that of the normal pediatric population (4.2%). It is important to recognize this higher incidence of these abnormalities and to anticipate… Show more

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Cited by 22 publications
(12 citation statements)
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“…They attempted to develop a means to measure this abnormality and recognize the difficulty in doing this without a valid control group (Figure 44.16). 17 This finding has been noted previously by other authors. 38,39 Ambulatory children with OI have a tendency to a significantly increased lumbar lordosis with an increased pelvic incidence at the lumbosacral junction.…”
Section: Figure 449supporting
confidence: 81%
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“…They attempted to develop a means to measure this abnormality and recognize the difficulty in doing this without a valid control group (Figure 44.16). 17 This finding has been noted previously by other authors. 38,39 Ambulatory children with OI have a tendency to a significantly increased lumbar lordosis with an increased pelvic incidence at the lumbosacral junction.…”
Section: Figure 449supporting
confidence: 81%
“…They did note that the vast majority of the children were ambulatory, and that essentially all were treated with bisphosphonates and, where indicated, surgical realignment and intramedullary stabilization of their extremities was performed. 17 Hatz also noted the abnormal elongation of the pedicles in 40% of their patients, essentially all in children with the more severe forms of OI (Figure 44.15). They attempted to develop a means to measure this abnormality and recognize the difficulty in doing this without a valid control group (Figure 44.16).…”
Section: Figure 449mentioning
confidence: 92%
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“…A study by Hatz et al observed a spondyloly sis incidence of 8.2% and a spondylolisthesis incidence of 10.9% in pediatric OI patients. 11 As a comparison, normal children below the age of 6 have a spondylolysis incidence of 4.4%, which increases to 6% in the adult population. 12 Spondylolisthesis incidences range from less than 3% in children to 6-8% in adults.…”
Section: Spondylolisthesis and Spondylolysismentioning
confidence: 98%
“…One recent spine x-ray review of a large osteogenesis imperfecta clinic population showed a significant increase in spondylolysis and spondylolisthesis above the incidence reported in otherwise normal children. The vast majority of these children had type III and type IV OI, and were ambulatory following treatment with bisphosphonates (Hatz et al, 2011). The long term implications are unclear.…”
Section: Wwwintechopencommentioning
confidence: 99%