The incidence of surgical site infections in China

Lin, Johnson; Peng, Yalan; Guo, Linxin; Tao, Siyuan; Li, Shiyu; Huang, Wenzhang; Yang, Xiangsheng; Qiao, Fei; Zong, Zhiyong

doi:10.1016/j.jhin.2023.06.004

Cited by 2 publications

(1 citation statement)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent decades, significant research efforts have been focused on developing treatments that facilitate wound healing and inhibit scar formation. Traditional approaches have mainly centered on debridement of necrotic tissue, infection control, and the application of growth factors to promote granulation tissue formation, fostering a favorable microenvironment for wound healing ( Fadilah et al, 2023 ; Lin et al, 2023 ; Ni et al, 2023 ). Nevertheless, current strategies for wound repair treatment have limitations, especially for severe burns and chronic skin ulcers, due to persistent inflammation, impaired angiogenesis, and inadequate extracellular matrix remodeling within the wound microenvironment ( Liu et al, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

Advancements in engineered exosomes for wound repair: current research and future perspectives

Ye,

Wang,

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Wound healing is a complex and prolonged process that remains a significant challenge in clinical practice. Exosomes, a type of nanoscale extracellular vesicles naturally secreted by cells, are endowed with numerous advantageous attributes, including superior biocompatibility, minimal toxicity, and non-specific immunogenicity. These properties render them an exceptionally promising candidate for bioengineering applications. Recent advances have illustrated the potential of exosome therapy in promoting tissue repair. To further augment their therapeutic efficacy, the concept of engineered exosomes has been proposed. These are designed and functionally modifiable exosomes that have been tailored on the attributes of natural exosomes. This comprehensive review delineates various strategies for exosome engineering, placing specific emphasis on studies exploring the application of engineered exosomes for precision therapy in wound healing. Furthermore, this review sheds light on strategies for integrating exosomes with biomaterials to enhance delivery effectiveness. The insights presented herein provide novel perspectives and lay a robust foundation for forthcoming research in the realm of cutaneous wound repair therapies.

show abstract