The Incidence of Ulcerative Colitis Has Doubled Since 1999

Devadason, David; Hussien, Hatem; Spray, Christine; Sandhu, BK

doi:10.1097/00005176-200505000-00097

Cited by 3 publications

(1 citation statement)

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“…As in adult populations, studies in children from the late 1990s suggest that CD appears to have a rising incidence over time, while that of UC appears stable [1]. However, a small study from Bristol, England, comparing the period of 1995 to 1999 with that of 2000 to 2004 suggests just the opposite: stable CD incidence rates (3.6-3.1 per 100,000) but a doubling of UC incidence rates (1.1-2.7 per 100,000) [2]. Data from North America suggest that children demonstrate a steadily rising incidence of CD and UC from middle childhood through adolescence, with an incidence of CD of 13 per 100,000 by age 10 years and 16 per 100,000 by age 15 years [3,4].…”

Section: Epidemiologymentioning

confidence: 99%

IBD in children: Lessons for adults

Haller

Markowitz²

2007

Curr Gastroenterol Rep

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When children develop inflammatory bowel disease (IBD), physicians and researchers are presented with a singular opportunity to understand the nature of these chronic, idiopathic illnesses in the earliest stages. Genetic susceptibility factors tend to be common, whereas complicating environmental factors such as cigarette smoking are generally not an issue. As opposed to the case in adult patients, Crohn's disease is usually diagnosed in children at an early, inflammatory phase of the disease. Pediatric ulcerative colitis tends to present with more severe and more extensive involvement than in adults. In both forms of IBD, the severity of disease activity often dictates the need for early aggressive nutritional, immunomodulatory, and biologic therapy. As a result, the lessons learned from the evaluation and treatment of children with IBD are critically important to the clinician caring for adults with the same disorders.

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Section: Epidemiologymentioning

confidence: 99%

IBD in children: Lessons for adults

Haller

Markowitz²

2007

Curr Gastroenterol Rep

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Epidemiology of inflammatory bowel diseases in childhood

Ravikumara

Sandhu

2006

Indian J Pediatr

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Inflammatory Bowel Disease (IBD) is common in most industrialised countries and childhood IBD accounts for nearly 30% of total cases. Various studies, mostly from Europe and USA have reported epidemiological characteristics of childhood IBD. The incidence figures vary greatly from region to region and within a region over time. Almost all reported studies have documented an increase in the incidence, mainly of Crohn's disease over the last few decades. The reasons for the increase are not clear but epidemiological observations have led to many postulates. Incidence in developing countries is perceived to be low, but limited data suggest that it may not be as uncommon as previously thought. IBD can occur at any age but is rare in infancy. Among childhood IBD, early onset IBD appears to be different epidemiologically and is characterised by predominance of colonic involvement and high positive family history. It has become apparent that only about 25% of childhood Crohn's disease presents with classical triad of abdominal pain, diarrhoea and weight loss. Pediatricians should be aware of atypical manifestations and should maintain high index of suspicion. Though epidemiological studies of childhood IBD done so far have contributed towards understanding of IBD, they have differed in study design, population, time period, age group and case definitions. Unfortunately there are no uniform, clear diagnostic criteria which are evidence based. To address this problem, recently the IBD working group of European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has published "The Porto Criteria" which details a consensus based diagnostic criteria for the diagnosis of childhood IBD. This should bring uniformity in ascertainment of newly diagnosed IBD cases. An European multicentre prospective database has also been established to facilitate future epidemiological studies.

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